Search Results - "Molecular aspects of medicine"

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues by Parola, Maurizio, Pinzani, Massimo

“…The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic parenchymal injury, persistent activation of inflammatory response…”
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Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities by Frangogiannis, Nikolaos G.

“…Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases, and is associated with systolic and diastolic dysfunction,…”
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Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications by Weiskirchen, Ralf, Weiskirchen, Sabine, Tacke, Frank

“…Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to injury in many tissues. Although the extracellular matrix deposition…”
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MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance by Iqbal, Mohammad Askandar, Arora, Shweta, Prakasam, Gopinath, Calin, George A., Syed, Mansoor Ali

“…Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of therapy throughout the world. Clinical success of therapies is not very…”
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The NLRP3 inflammasome: Mechanism of action, role in disease and therapies by Wang, Li, Hauenstein, Arthur V.

“…NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can detect microbial motifs, endogenous danger and stress signals…”
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Cellular and molecular mechanisms of kidney fibrosis by Djudjaj, Sonja, Boor, Peter

“…Renal fibrosis is the final pathological process common to any ongoing, chronic kidney injury or maladaptive repair. It is considered as the underlying…”
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Autophagy in liver diseases: A review by Qian, Hui, Chao, Xiaojuan, Williams, Jessica, Fulte, Sam, Li, Tiangang, Yang, Ling, Ding, Wen-Xing

“…The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein synthesis, gluconeogenesis and glycogen storage, cholesterol…”
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NK cells and ILCs in tumor immunotherapy by Sivori, Simona, Pende, Daniela, Quatrini, Linda, Pietra, Gabriella, Della Chiesa, Mariella, Vacca, Paola, Tumino, Nicola, Moretta, Francesca, Mingari, Maria Cristina, Locatelli, Franco, Moretta, Lorenzo

“…Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells can control tumor growth and metastatic spread. Thanks to their…”
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Developmental pathways in the pathogenesis of lung fibrosis by Chanda, Diptiman, Otoupalova, Eva, Smith, Samuel R., Volckaert, Thomas, De Langhe, Stijn P., Thannickal, Victor J.

“…Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known cure. IPF is a disease of aging, with median age of diagnosis over…”
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Iron in infection and immunity by Nairz, Manfred, Weiss, Günter

“…Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both invading pathogens and mammalian cells including those of the…”
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Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential by Saus, Ester, Iraola-Guzmán, Susana, Willis, Jesse R., Brunet-Vega, Anna, Gabaldón, Toni

“…The gastrointestinal tract harbors most of the microbiota associated with humans. In recent years, there has been a surge of interest in assessing the…”
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Molecular mechanisms of oxidative stress in asthma by Michaeloudes, Charalambos, Abubakar-Waziri, Hisham, Lakhdar, Ramzi, Raby, Katie, Dixey, Piers, Adcock, Ian M., Mumby, Sharon, Bhavsar, Pankaj K., Chung, Kian Fan

“…The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of inhalation of oxygen, as well as smoke and other air pollutants. Cell…”
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An overview of the non-canonical inflammasome by Downs, Kevin P., Nguyen, Huyen, Dorfleutner, Andrea, Stehlik, Christian

“…Inflammasomes are large cytosolic multiprotein complexes assembled in response to infection and cellular stress, and are crucial for the activation of…”
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Circulating biomarkers for early detection and clinical management of colorectal cancer by Marcuello, María, Vymetalkova, Veronika, Neves, Rui P.L., Duran-Sanchon, Saray, Vedeld, Hege Marie, Tham, Emma, van Dalum, Guus, Flügen, Georg, Garcia-Barberan, Vanesa, Fijneman, Remond JA, Castells, Antoni, Vodicka, Pavel, Lind, Guro E., Stoecklein, Nikolas H., Heitzer, Ellen, Gironella, Meritxell

“…New non-invasive approaches that can complement and improve on current strategies for colorectal cancer (CRC) screening and management are urgently needed. A…”
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ROS signaling and ER stress in cardiovascular disease by Ochoa, Cristhiaan D., Wu, Ru Feng, Terada, Lance S.

“…The endoplasmic reticulum (ER) produces the vast majority of all proteins secreted into the extracellular space, including hormones and cytokines, as well as…”
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Interactions between gut bacteria and bile in health and disease by Long, Sarah L., Gahan, Cormac G.M., Joyce, Susan A.

“…Bile acids are synthesized from cholesterol in the liver and released into the intestine to aid the digestion of dietary lipids. The host enzymes that…”
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Lifestyle and dietary environmental factors in colorectal cancer susceptibility by Murphy, Neil, Moreno, Victor, Hughes, David J., Vodicka, Ludmila, Vodicka, Pavel, Aglago, Elom K., Gunter, Marc J., Jenab, Mazda

“…Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by…”
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HMGB1 in health and disease by Kang, Rui, Chen, Ruochan, Zhang, Qiuhong, Hou, Wen, Wu, Sha, Cao, Lizhi, Huang, Jin, Yu, Yan, Fan, Xue-gong, Yan, Zhengwen, Sun, Xiaofang, Wang, Haichao, Wang, Qingde, Tsung, Allan, Billiar, Timothy R., Zeh, Herbert J., Lotze, Michael T., Tang, Daolin

“…Complex genetic and physiological variations as well as environmental factors that drive emergence of chromosomal instability, development of unscheduled cell…”
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Flavonoids and the gastrointestinal tract: Local and systemic effects by Oteiza, P.I., Fraga, C.G., Mills, D.A., Taft, D.H.

“…The gastrointestinal (GI) tract plays a central role in the absorption, distribution, metabolism, and excretion of flavonoids, which ultimately define the…”
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Single-cell RNA sequencing: Technical advancements and biological applications by Hedlund, Eva, Deng, Qiaolin

“…Cells are the basic building blocks of organisms and each cell is unique. Single-cell RNA sequencing has emerged as an indispensable tool to dissect the…”
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