Search Results - "Molecular and chemical neuropathology"

Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease? by Blennow, K, Wallin, A, Agren, H, Spenger, C, Siegfried, J, Vanmechelen, E

“…Cerebrospinal fluid (CSF) biochemical markers for Alzheimer disease (AD) would be of great value to improve the clinical diagnostic accuracy of the disorder…”
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Progesterone protects against lipid peroxidation following traumatic brain injury in rats by Roof, R L, Hoffman, S W, Stein, D G

“…The gonadal hormone, progesterone, has been shown to have neuroprotective effects in injured nervous system, including the severity of postinjury cerebral…”
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Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain by Mecocci, P, Beal, M F, Cecchetti, R, Polidori, M C, Cherubini, A, Chionne, F, Avellini, L, Romano, G, Senin, U

“…Oxidative damage on biological molecules has been proposed as a major cause of alterations observed in aging brain as well as in neurodegenerative diseases. In…”
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Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia by Wang, X, Yue, T L, Barone, F C, White, R F, Gagnon, R C, Feuerstein, G Z

“…The expression of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) mRNAs was significantly increased in the rat ischemic cortex…”
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Pathology of Parkinson's disease : changes other than the nigrostriatal pathway by JELLINGER, K. A

“…In Parkinson's disease (PD), in addition to degeneration of the nigrostriatal dopaminergic pathway, a variety of neuronal systems are involved, causing…”
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Blood levels of histamine, IL-1 beta, and TNF-alpha in patients with mild to moderate Alzheimer disease by Alvarez, X A, Franco, A, Fernández-Novoa, L, Cacabelos, R

“…In this study, we have evaluated the levels of blood histamine, serum interleukin-1 beta (IL-1 beta), and plasma tumor necrosis factor-alpha (TNF-alpha) in 20…”
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Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease by Draczynska-Lusiak, B, Doung, A, Sun, A Y

“…Oxidative stress in the central nervous system (CNS) may cause oxidation of lipoprotein particles. The oxidized lipoproteins may damage cellular and…”
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Aging modulates nitric oxide synthesis and cGMP levels in hippocampus and cerebellum. Effects of amyloid beta peptide by Chalimoniuk, M, Strosznajder, J B

“…The biological roles of nitric oxide (NO) and cGMP as inter- and intracellular messengers have been intensively investigated during the last decade. NO and…”
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Distribution and isoform diversity of the organellar Ca2+ pumps in the brain by Baba-Aissa, F, Raeymaekers, L, Wuytack, F, Dode, L, Casteels, R

“…The gene family of organellar-type Ca2+ transport ATPases consists of three members. SERCA1 is expressed exclusively in fast skeletal muscle; SERCA2 is…”
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Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments by Forloni, G, Bugiani, O, Tagliavini, F, Salmona, M

“…The neurotoxic activity of beta-amyloid (beta A) and prion protein (PrP) fragments contributed to the hypothesis concerning a causal role of amyloid deposits…”
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Species differences in the generation of reactive oxygen species by microglia by Colton, C, Wilt, S, Gilbert, D, Chernyshev, O, Snell, J, Dubois-Dalcq, M

“…Although a variety of potential sources for reactive oxygen species (ROS) exist in the CNS, brain macrophages, i.e., the microglia, generate large quantities…”
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Regulation of metallothionein-III (GIF) mRNA in the brain of patients with Alzheimer disease is not impaired by Amoureux, M C, Van Gool, D, Herrero, M T, Dom, R, Colpaert, F C, Pauwels, P J

“…Contradictory results have been reported on the downregulation and role of the brain-specific protein metallothionein-III (MT-III, GIF) in Alzheimer disease…”
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Immunogenetic studies in autism and related disorders by Warren, R P, Singh, V K, Averett, R E, Odell, J D, Maciulis, A, Burger, R A, Daniels, W W, Warren, W L

“…The major histocompatibility complex comprises a number of genes that control the function and regulation of the immune system. One of these genes, the C4B…”
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Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury by Yakovlev, A G, Faden, A I

“…Reverse transcription-polymerase chain reaction (RT-PCR) was used to estimate dynamic changes in levels of c-fos protooncogene, tumor necrosis factor alpha…”
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Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage in amyloid beta protein precursor-mediated cell death by Sopher, B L, Fukuchi, K, Kavanagh, T J, Furlong, C E, Martin, G M

“…We have established a stably transformed human neuroblastoma cell line (MC65) that conditionally expresses a C-terminal derivative of the amyloid beta protein…”
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Serum extravasation and cytoskeletal alterations following traumatic brain injury in rats. Comparison of lateral fluid percussion and cortical impact models by Hicks, R R, Baldwin, S A, Scheff, S W

“…Disruption of the blood-brain barrier (BBB) and neuronal cytoskeletal damage were evaluated in two commonly used rat models of traumatic brain injury. Adult…”
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Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation by Baum, L, Hansen, L, Masliah, E, Saitoh, T

“…Highly phosphorylated tau protein is the main component of paired helical filaments (PHF), which comprise the neurofibrillary tangles (NFT) in some neurons of…”
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Lithium prevents ouabain-induced behavioral changes. Toward an animal model for manic depression by Li, R, el-Mallakh, R S, Harrison, L, Changaris, D G, Levy, R S

“…Both mania and bipolar depression have been associated with decrements in the activity of the sodium and potassium-activated adenosine triphosphatase…”
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Nitric oxide synthase (NOS) in schizophrenia: increases in cerebellar vermis by Karson, C N, Griffin, W S, Mrak, R E, Husain, M, Dawson, T M, Snyder, S H, Moore, N C, Sturner, W Q

“…A high proportion of neurons in the cerebellum and in cholinergic brainstem nuclei stain positive for nicotinamide adenine dinucleotide phosphate-diaphorase…”
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Aluminum potentiates glutamate-induced calcium accumulation and iron-induced oxygen free radical formation in primary neuronal cultures by Mundy, W R, Freudenrich, T M, Kodavanti, P R

“…Aluminum is a neurotoxic metal that may be involved in the progression of neurodegenerative diseases, including Alzheimer disease and amyotrophic lateral…”
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