Search Results - "Molecular and cellular biochemistry"

ROS and diseases: role in metabolism and energy supply by Yang, Shenshu, Lian, Gaojian

“…Researches dedicated to reactive oxygen species (ROS) had been performed for decades, yet the outcomes remain controversial. With the relentless effort of…”
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Role of PI3K/Akt signaling pathway in cardiac fibrosis by Qin, Wuming, Cao, Linghui, Massey, Isaac Yaw

“…Heart failure (HF) is considered as a severe health problem worldwide, while cardiac fibrosis is one of the main driving factors for the progress of HF…”
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Inside(sight) of tiny communicator: exosome biogenesis, secretion, and uptake by Jadli, Anshul S., Ballasy, Noura, Edalat, Pariya, Patel, Vaibhav B.

“…Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from reticulocytes, exosomes recently gained scientific attention due to…”
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Exploring the potential function of trace elements in human health: a therapeutic perspective by Islam, Md. Rezaul, Akash, Shopnil, Jony, Maruf Hossain, alam, Md. Noor, Nowrin, Feana Tasmim, Rahman, Md. Mominur, Rauf, Abdur, Thiruvengadam, Muthu

“…A trace element, known as a minor element, is a chemical element whose concentration is very low. They are divided into essential and non-essential classes…”
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Exosomes: cell-created drug delivery systems by Familtseva, Anastasia, Jeremic, Nevena, Tyagi, Suresh C.

“…Exosomes are 40- to 100- nm cell-originated vesicles derived from endocytic compartments that are released into almost all biological fluids. Exosomes are…”
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Bone marrow mesenchymal stem cell-secreted exosomes carrying microRNA-125b protect against myocardial ischemia reperfusion injury via targeting SIRT7 by Chen, Qi, Liu, Yu, Ding, Xueyan, Li, Qinfeng, Qiu, Fuyu, Wang, Meihui, Shen, Zhida, Zheng, Hao, Fu, Guosheng

“…MicroRNA-125b (miR-125b) reduces myocardial infarct area and restrains myocardial ischemia reperfusion injury (I/R). In this study, we aimed to investigate the…”
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Rheumatoid arthritis: advances in treatment strategies by Prasad, Peeyush, Verma, Sneha, Surbhi, Ganguly, Nirmal Kumar, Chaturvedi, Ved, Mittal, Shivani Arora

“…Rheumatoid arthritis (RA) is characterised by severe joint and bone damage due to heightened autoimmune response at the articular sites. Worldwide annual…”
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Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling by Luo, Li-Fei, Guan, Peng, Qin, Lu-Yun, Wang, Jian-Xin, Wang, Na, Ji, En-Sheng

“…Astragaloside IV (AsIV), an active ingredient isolated from traditional Chinese medicine astragalus membranaceus, is beneficial to cardiovascular health. This…”
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Melatonin and its ubiquitous anticancer effects by Bhattacharya, Sankha, Patel, Krishna Kumar, Dehari, Deepa, Agrawal, Ashish Kumar, Singh, Sanjay

“…Melatonin ( N -acetyl-5-methoxy-tryptamine), which is generally considered as pleiotropic and multitasking molecule, secretes from pineal gland at night under…”
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The potential role of neopterin in Covid-19: a new perspective by Al-kuraishy, Hayder M., Al-Gareeb, Ali I., Alzahrani, Khalid J., Cruz-Martins, Natália, Batiha, Gaber El-Saber

“…Neopterin (NPT) is a member of pteridines group, synthesized by macrophages when stimulated by interferon gamma (INF-γ). NPT is regarded as a macrophage…”
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Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective review by Ramasubbu, Kanagavalli, Devi Rajeswari, V.

“…Insulin resistance is common in type 2 diabetes mellitus (T2DM), neurodegenerative diseases, cardiovascular diseases, kidney diseases, and polycystic ovary…”
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Role of Bcl-2 family proteins and caspases in the regulation of apoptosis by Ola, Mohammad Shamsul, Nawaz, Mohd, Ahsan, Haseeb

“…Apoptosis, or programmed cell death, plays a pivotal role in the elimination of unwanted, damaged, or infected cells in multicellular organisms and also in…”
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Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance by Nandipati, Kalyana C., Subramanian, Saravanan, Agrawal, Devendra K.

“…Obesity-induced low-grade inflammation (metaflammation) impairs insulin receptor signaling. This has been implicated in the development of insulin resistance…”
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AGE-RAGE synergy influences programmed cell death signaling to promote cancer by Waghela, Bhargav N., Vaidya, Foram U., Ranjan, Kishu, Chhipa, Abu Sufiyan, Tiwari, Budhi Sagar, Pathak, Chandramani

“…Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction between the free reducing sugars and proteins, lipids, or nucleic…”
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Low-grade neuroinflammation due to chronic sleep deprivation results in anxiety and learning and memory impairments by Manchanda, Shaffi, Singh, Harpal, Kaur, Taranjeet, Kaur, Gurcharan

“…Chronic sleep loss/fragmentation prevalent in the current 24/7 society is associated with irreversible consequences on health and overall wellbeing. Various…”
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Role of miRNA-210, miRNA-21 and miRNA-126 as diagnostic biomarkers in colorectal carcinoma: impact of HIF-1[alpha]-VEGF signaling pathway by Sabry, Dina, El-Deek, Sahar E. M, Maher, Moataz, El-Baz, Mona A. H, El-Bader, Hala M, Amer, Eman, Hassan, Elham A

“…Colorectal cancer (CRC) is a major cause of death worldwide. Novel non-invasive, high diagnostic value screening test is urgently needed to improve survival…”
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Oxidative stress in metabolic diseases: current scenario and therapeutic relevance by Raut, Satish K., Khullar, Madhu

“…The metabolic syndrome is a clustering condition of increased abdominal obesity in concert with hyperglycemia, insulin resistance, hypertension, and…”
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Metals, oxidative stress and neurodegenerative disorders by Jomova, Klaudia, Vondrakova, Dagmar, Lawson, Michael, Valko, Marian

“…The neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD), are age-related disorders characterized by the deposition of abnormal…”
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Modulation of endothelium function by fatty acids by Mallick, Rahul, Duttaroy, Asim K.

“…The endothelium acts as the barrier that prevents circulating lipids such as lipoproteins and fatty acids into the arterial wall; it also regulates normal…”
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Regulation of GSK3β/Nrf2 signaling pathway modulated erastin-induced ferroptosis in breast cancer by Wu, Xinghan, Liu, Chuanliang, Li, Zihaoran, Gai, Chengcheng, Ding, Dejun, Chen, Weijuan, Hao, Fengyun, Li, Wentong

“…Ferroptosis is a newly discovered form of regulated cell death and characterized by an iron-dependent accumulation of lethal lipid reactive oxygen species…”
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