Search Results - "Molecular and Cellular Endocrinology"

Short chain fatty acids: Microbial metabolites for gut-brain axis signalling by O'Riordan, Kenneth J., Collins, Michael K., Moloney, Gerard M., Knox, Emily G., Aburto, María R., Fülling, Christine, Morley, Shane J., Clarke, Gerard, Schellekens, Harriët, Cryan, John F.

“…The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship…”
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Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway by Ren, Huiwen, Shao, Ying, Wu, Can, Ma, Xiaoyu, Lv, Chuan, Wang, Qiuyue

“…Metformin, as the basic pharmacological therapy and the first preventive drug in type 2 diabetes mellitus (T2DM), is proved to have potential protection in…”
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Parabens and their effects on the endocrine system by Nowak, Karolina, Ratajczak–Wrona, Wioletta, Górska, Maria, Jabłońska, Ewa

“…Preservatives (ingredients which inhibit growth of microorganisms) are used to prolong shelf life of various foods, cosmetics, and pharmaceutical products…”
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The sexual dimorphism of obesity by Palmer, Biff F., Clegg, Deborah J.

“…The NIH has recently highlighted the importance of sexual dimorphisms and has mandated inclusion of both sexes in clinical trials and basic research. In this…”
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Discovery of farnesoid X receptor and its role in bile acid metabolism by Chiang, John Y.L., Ferrell, Jessica M.

“…In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was identified as a farnesol receptor expressed mainly in liver, kidney, and…”
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Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition by Groner, Bernd, von Manstein, Viktoria

“…The effects of Jak Stat signaling and the persistent activation of Stat3 and Stat5 on tumor cell survival, proliferation and invasion have made the Jak Stat…”
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Nuclear receptors are the major targets of endocrine disrupting chemicals by Toporova, Lucia, Balaguer, Patrick

“…Endocrine disrupting chemicals (EDCs) are exogenous substances that are suspected to cause adverse effects in the endocrine system mainly by acting through…”
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Thyroid hormone biosynthesis and release by Carvalho, Denise P., Dupuy, Corinne

“…Thyroid hormones (TH) 3,5,3′,5’- tetraiodothyronine or thyroxine (T4) and 3,5,3’- triiodothyronine (T3) contain iodine atoms as part of their structure, and…”
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NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice by Wu, Ming, Han, Weixia, Song, Shan, Du, Yunxia, Liu, Chao, Chen, Nan, Wu, Haijiang, Shi, Yonghong, Duan, Huijun

“…Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Activation of the nucleotide binding and oligomerization domain-like receptor family…”
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Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link? by Asrih, Mohamed, Jornayvaz, François R.

“…Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is…”
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Development of selective androgen receptor modulators (SARMs) by Narayanan, Ramesh, Coss, Christopher C., Dalton, James T.

“…The Androgen Receptor (AR), a member of the steroid hormone receptor family, plays important roles in the physiology and pathology of diverse tissues. AR…”
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Metformin improves obesity-associated inflammation by altering macrophages polarization by Jing, Yuanyuan, Wu, Fan, Li, Dai, Yang, Lei, Li, Qi, Li, Rong

“…Obesity is reported to be a chronic low-grade inflammatory state. Adipose tissue macrophages play a key role in obesity-related inflammation. Metformin, the…”
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Endocrine resistance in breast cancer – An overview and update by Clarke, Robert, Tyson, John J., Dixon, J. Michael

“…Tumors that express detectable levels of the product of the ESR1 gene (estrogen receptor-α; ERα) represent the single largest molecular subtype of breast…”
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Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation by Lee, Taeseung, Yun, Subin, Jeong, Ji Hoon, Jung, Tae Woo

“…Severe inflammation in the islets is observed in obese patients with type 2 diabetes. Inflammation in the islets is caused by obesity-induced serum free fatty…”
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Disorders of IGFs and IGF-1R signaling pathways by Forbes, Briony E., Blyth, Andrew J., Wit, Jan M.

“…The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian…”
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Intracrine androgen biosynthesis, metabolism and action revisited by Schiffer, Lina, Arlt, Wiebke, Storbeck, Karl-Heinz

“…Androgens play an important role in metabolic homeostasis and reproductive health in both men and women. Androgen signalling is dependent on androgen receptor…”
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The role of vitamin D in the endocrinology controlling calcium homeostasis by Fleet, James C.

“…Vitamin D and its' metabolites are a crucial part of the endocrine system that controls whole body calcium homeostasis. The goal of this hormonal control is to…”
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Cryo-EM structures of GPCRs coupled to G s , G i and G o by García-Nafría, Javier, Tate, Christopher G

“…Advances in electron cryo-microscopy (cryo-EM) now permit the structure determination of G protein-coupled receptors (GPCRs) coupled to heterotrimeric G…”
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Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression by Stamatiades, George A., Kaiser, Ursula B.

“…The precise orchestration of hormonal regulation at all levels of the hypothalamic-pituitary-gonadal axis is essential for normal reproductive function and…”
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Vitamin D and the brain: Genomic and non-genomic actions by Cui, Xiaoying, Gooch, Helen, Petty, Alice, McGrath, John J., Eyles, Darryl

“…1,25(OH)2D3 (vitamin D) is well-recognized as a neurosteroid that modulates multiple brain functions. A growing body of evidence indicates that vitamin D plays…”
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