Search Results - "Molecular and Cellular Biology"

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway by Baird, Liam, Yamamoto, Masayuki

“…The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3…”
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Transcriptional and Epigenomic Regulation of Adipogenesis by Lee, Ji-Eun, Schmidt, Hannah, Lai, Binbin, Ge, Kai

“…Understanding adipogenesis, the process of adipocyte development, may provide new ways to treat obesity and related metabolic diseases. Adipogenesis is…”
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AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550 by Joo, Min Sung, Kim, Won Dong, Lee, Ki Young, Kim, Ji Hyun, Koo, Ja Hyun, Kim, Sang Geon

“…Nrf2 (nuclear factor erythroid 2-related factor 2) is an antioxidant transcription factor. AMP-activated protein kinase (AMPK) functions as a central regulator…”
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Signaling Pathways Involved in the Regulation of mRNA Translation by Roux, Philippe P., Topisirovic, Ivan

“…Translation is a key step in the regulation of gene expression and one of the most energy-consuming processes in the cell. In response to various stimuli,…”
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Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer's Disease Model Mice by Uruno, Akira, Matsumaru, Daisuke, Ryoke, Rie, Saito, Ritsumi, Kadoguchi, Shiori, Saigusa, Daisuke, Saito, Takashi, Saido, Takaomi C., Kawashima, Ryuta, Yamamoto, Masayuki

“…Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether Nrf2 prevents…”
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When Long Noncoding Becomes Protein Coding by Hartford, Corrine Corrina R., Lal, Ashish

“…Recent advancements in genetic and proteomic technologies have revealed that more of the genome encodes proteins than originally thought possible…”
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Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks by Alers, Sebastian, Löffler, Antje S., Wesselborg, Sebastian, Stork, Björn

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AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue by Kim, Sun-Joong, Tang, Tianyi, Abbott, Marcia, Viscarra, Jose A., Wang, Yuhui, Sul, Hei Sook

“…The role of AMP-activated protein kinase (AMPK) in promoting fatty acid (FA) oxidation in various tissues, such as liver and muscle, has been well understood…”
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SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress by Samant, Sadhana A., Zhang, Hannah J., Hong, Zhigang, Pillai, Vinodkumar B., Sundaresan, Nagalingam R., Wolfgeher, Donald, Archer, Stephen L., Chan, David C., Gupta, Mahesh P.

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The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis by Kobayashi, Masatoshi, Ohsugi, Mitsuru, Sasako, Takayoshi, Awazawa, Motoharu, Umehara, Toshihiro, Iwane, Aya, Kobayashi, Naoki, Okazaki, Yukiko, Kubota, Naoto, Suzuki, Ryo, Waki, Hironori, Horiuchi, Keiko, Hamakubo, Takao, Kodama, Tatsuhiko, Aoe, Seiichiro, Tobe, Kazuyuki, Kadowaki, Takashi, Ueki, Kohjiro

“…Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be…”
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Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes by Min, Jaewon, Wright, Woodring E., Shay, Jerry W.

“…Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset of cancers. By analyzing…”
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Lysine Demethylase KDM6A in Differentiation, Development, and Cancer by Tran, Nhien, Broun, Aaron, Ge, Kai

“…Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B…”
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Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response by Saito, Ryota, Suzuki, Takafumi, Hiramoto, Keiichiro, Asami, Soichiro, Naganuma, Eriko, Suda, Hiromi, Iso, Tatsuro, Yamamoto, Hirotaka, Morita, Masanobu, Baird, Liam, Furusawa, Yuki, Negishi, Takaaki, Ichinose, Masakazu, Yamamoto, Masayuki

“…The Keap1-Nrf2 system plays a central role in cytoprotection against electrophilic/oxidative stresses. Although Cys151, Cys273, and Cys288 of Keap1 are major…”
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Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia by Joseph, Giselle A., Wang, Sharon X., Jacobs, Cody E., Zhou, Weihua, Kimble, Garrett C., Tse, Herman W., Eash, John K., Shavlakadze, Tea, Glass, David J.

“…There is a lack of pharmacological interventions available for sarcopenia, a progressive age-associated loss of muscle mass, leading to a decline in mobility…”
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The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers by Hu, Deqing, Gao, Xin, Morgan, Marc A., Herz, Hans-Martin, Smith, Edwin R., Shilatifard, Ali

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Looking Down on NF-κB by Williams, Leah M., Gilmore, Thomas D.

“…The diversified NF-κB transcription factor family has been extensively characterized in organisms ranging from flies to humans. However, homologs of NF-κB and…”
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The New State of the Art: Cas9 for Gene Activation and Repression by La Russa, Marie F., Qi, Lei S.

“…CRISPR-Cas9 technology has rapidly changed the landscape for how biologists and bioengineers study and manipulate the genome. Derived from the bacterial…”
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Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress by Saikia, Mridusmita, Jobava, Raul, Parisien, Marc, Putnam, Andrea, Krokowski, Dawid, Gao, Xing-Huang, Guan, Bo-Jhih, Yuan, Yiyuan, Jankowsky, Eckhard, Feng, Zhaoyang, Hu, Guo-fu, Pusztai-Carey, Marianne, Gorla, Madhavi, Sepuri, Naresh Babu V., Pan, Tao, Hatzoglou, Maria

“…Adaptation to changes in extracellular tonicity is essential for cell survival. However, severe or chronic hyperosmotic stress induces apoptosis, which…”
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Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle by Jheng, Huei-Fen, Tsai, Pei-Jane, Guo, Syue-Maio, Kuo, Li-Hua, Chang, Cherng-Shyang, Su, Ih-Jen, Chang, Chuang-Rung, Tsai, Yau-Sheng

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Exosome-Mediated Transfer of circ_0000338 Enhances 5-Fluorouracil Resistance in Colorectal Cancer through Regulating MicroRNA 217 (miR-217) and miR-485-3p by Zhao, Kui, Cheng, Xiaohui, Ye, Zhenyu, Li, Yecheng, Peng, Wei, Wu, Yongyou, Xing, Chungen

“…Exosomes are microvesicles secreted by body cells for intercellular communication. The circular RNA circ_0000338 was found to be present in extracellular…”
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