Search Results - "Mole, M L"

Developmental toxicity of mixtures: the water disinfection by-products dichloro-, dibromo- and bromochloro acetic acid in rat embryo culture by Andrews, J.E., Nichols, H.P., Schmid, J.E., Mole, L.M., Hunter, E.S., Klinefelter, G.R.

“…The chlorination of drinking water results in production of numerous disinfection by-products (DBPs). One of the important classes of DBPs is the haloacetic…”
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Dibromoacetic acid, a prevalent by-product of drinking water disinfection, compromises the synthesis of specific seminiferous tubule proteins following both in vivo and in vitro exposures by Holmes, M, Suarez, J. D, Roberts, N. L, Mole, M. L, Murr, A. S, Klinefelter, G. R

“…Dibromoacetic acid (DBA) is a by‐product of drinking water disinfection that alters spermatogenesis in adult male rats. To identify a mechanism by which DBA…”
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Developmental toxicity of methanol in whole embryo culture: a comparative study with mouse and rat embryos by Andrews, J E, Ebron-McCoy, M, Logsdon, T R, Mole, L M, Kavlock, R J, Rogers, J M

“…Methanol (MeOH), a widely used industrial solvent, has been proposed as an alternative motor vehicle fuel. Inhaled MeOH is developmentally toxic in both rats…”
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Nucleoside-Mediated Mitigation of 5-Fluorouracil-Induced Toxicity in Synchronized Murine Erythroleukemic Cells by Elstein, Kenneth H., Mole, M.Leonard, Setzer, R.Woodrow, Zucker, Robert M., Kavlock, Robert J., Rogers, John M., Lau, Christopher

“…5-Fluorouracil (5-FU) is a chemotherapeutic agent known to retard embryonic growth and induce cleft palate and limb deformities. The predominant mechanism…”
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Effect of ozone on serum lipids and lipoproteins in the rat by Mole, Jr, M L, Stead, A G, Gardner, D E, Miller, F J, Graham, J A

“…Exposure of male rats to 0 (air), 1, 1.75, and 3 ppm ozone (O3) 5 hr/day for a total of 10 days resulted in a positive linear relationship between ozone…”
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Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat : A mathematical construct by SETZER, R. Woodrow, LAU, Christopher, MOLE, M. Leonard, COPELAND, M. Frank, ROGERS, John M, KAVLOCKT, Robert J

“…Biologically based dose-response (BBDR) models comprise one way to incorporate mechanistic information into a dose-response assessment to be used for risk…”
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High-performance liquid chromatographic assay of biphenyl metabolism by hepatocytes cultured in an embryo/hepatocyte co-culture medium by Mole, M L, Sanders, L, Oglesby, L A

“…A high-performance liquid chromatographic method has been modified for the evaluation of both Phase I and II metabolism of biphenyl by hepatocytes maintained…”
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Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat : Acquisition of experimental data by LAU, Christopher, MOLE, M. Leonard, SETZER, R. Woodrow, COPELAND, M. Frank, ROGERS, John M, KAVLOCK, Robert J, SHUEY, Dana L, CAMERON, Annie M, ELLIS, David H, LOGSDON, Tina R, MERRIMAN, Jennifer

“…Biologically based dose-response (BBDR) models represent an emerging approach to improving the current practice of human health-risk assessment. The concept of…”
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Influence of the drinking water disinfection by-product dibromoacetic acid on rat estrous cyclicity and ovarian follicular steroid release in vitro by Balchak, Sharon K, Hedge, Joan M, Murr, Ashley S, Leonard Mole, M, Goldman, Jerome M

“…The drinking water disinfection by-product, dibromoacetic acid (DBA) has been reported to affect gonadal functions in the male rat. However, there is little…”
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Saturation of lindane metabolism in chronically treated (YS x VY) F1 hybrid mice by Chadwick, R W, Copeland, M F, Wolff, G L, Stead, A G, Mole, M L, Whitehouse, D A

“…The organochlorine insecticide lindane (gamma-hexachlorocyclohexane) induces hepatomas in select strains of mice including two of three phenotypic classes of…”
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Constituents of Cannabis sativa L. VIII: Possible biological application of a new method to separate cannabidiol and cannabichromene by Turner, C E, Hadley, K W, Holley, J H, Billets, S, Mole, Jr, M L

“…Synthetic and naturally occurring cannabidiol and cannabichromene were distinctly separated without derivation by GLC using a 6% OV-1 column; an artifact of…”
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Sample Preparation and High-Performance Liquid Chromatographic Analysis of Deoxyribonucleoside Triphosphates in Individual Rat Embryos by Mole, M.Leonard, Hunter, Deborah L., Gao, Pu, Lau, Christopher

“…A rapid, robust, and sensitive method has been developed to measure concentrations of deoxyribonucleoside triphosphates in individual, day 14 rat embryos by…”
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Critical periods of sensitivity to the developmental toxicity of inhaled methanol in the CD-1 mouse by Rogers, John M., Mole, M. Leonard

“…Exposure of pregnant CD‐1 mice to methanol (MeOH) by inhalation on gestation days (gd) 6–15 results in dose‐related increases in fetal cleft palate,…”
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Influence of ozone on pentobarbital pharmacokinetics in mice by Graham, J A, Menzel, D B, Mole, M L, Miller, F J, Gardner, D E

“…Previous studies have indicated that acute exposure to ambient concentrations of ozone (O3) as low as 196 micrograms/m3 (0.1 ppm) increases pentobarbital…”
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The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses by Rogers, J M, Mole, M L, Chernoff, N, Barbee, B D, Turner, C I, Logsdon, T R, Kavlock, R J

“…The developmental toxicity of the alternative motor vehicle fuel methanol was assessed in mice by the inhalation route. Pregnant CD-1 mice were exposed to…”
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Stereoselective nonannelation synthesis of eudalene sesquiterpenes by Huffman, J. W, Mole, M. L

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Effects of age and obesity on the metabolism of lindane by black a/a, yellow Avy/a, and pseudoagouti Avy/a phenotypes of (YS x VY) F1 hybrid mice by Chadwick, R W, Copeland, M F, Wolff, G L, Cooke, N, Whitehouse, D A, Mole, M L

“…Lindane (gamma-hexachlorocyclohexane) has been shown to produce hepatomas in some strains of mice but not in others. Genetic factors and/or altered metabolism…”
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Assessment of offspring development and behavior following gestational exposure to inhaled methanol in the rat by Stanton, M E, Crofton, K M, Gray, L E, Gordon, C J, Boyes, W K, Mole, M L, Peele, D B, Bushnell, P J

“…The prospect of widespread human exposure associated with its use as an alternative fuel has sparked concern about the toxic potential of inhaled methanol…”
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Effect of inhaled methanol on pituitary and testicular hormones in chamber acclimated and non-acclimated rats by Cooper, R L, Mole, M L, Rehnberg, G L, Goldman, J M, McElroy, W K, Hein, J, Stoker, T E

“…Two experiments were conducted in which the acute effects of inhaled methanol on serum hormones associated with reproductive function in the male rat were…”
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Constituents of Cannabis sativa. XIX. Isolation and Structure Elucidation of Cannabiglendol, A Novel Cannabinoid From an Indian Variant by Turner, C. E, Mole, M. L, Hanus, L, Elsohly, H. N

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