Search Results - "Moldt, Manuela"

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing by Oberbeckmann, Elisa, Niebauer, Vanessa, Watanabe, Shinya, Farnung, Lucas, Moldt, Manuela, Schmid, Andrea, Cramer, Patrick, Peterson, Craig L., Eustermann, Sebastian, Hopfner, Karl-Peter, Korber, Philipp

“…Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by alignment to reference sites like active promoters. How the distances between…”
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Structural mechanism of cytosolic DNA sensing by cGAS by Civril, Filiz, Deimling, Tobias, de Oliveira Mann, Carina C., Ablasser, Andrea, Moldt, Manuela, Witte, Gregor, Hornung, Veit, Hopfner, Karl-Peter

“…Cytosolic DNA arising from intracellular bacterial or viral infections is a powerful pathogen-associated molecular pattern (PAMP) that leads to innate immune…”
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Genome information processing by the INO80 chromatin remodeler positions nucleosomes by Oberbeckmann, Elisa, Krietenstein, Nils, Niebauer, Vanessa, Wang, Yingfei, Schall, Kevin, Moldt, Manuela, Straub, Tobias, Rohs, Remo, Hopfner, Karl-Peter, Korber, Philipp, Eustermann, Sebastian

“…The fundamental molecular determinants by which ATP-dependent chromatin remodelers organize nucleosomes across eukaryotic genomes remain largely elusive. Here,…”
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Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling by Motz, Carina, Schuhmann, Kerstin Monika, Kirchhofer, Axel, Moldt, Manuela, Witte, Gregor, Conzelmann, Karl-Klaus, Hopfner, Karl-Peter

“…The retinoic acid—inducible gene I (RIG-I)—like receptor (RLR) melanoma differentiation—associated protein 5 (MDA5) senses cytoplasmic viral RNA and activates…”
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ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA by Lässig, Charlotte, Matheisl, Sarah, Sparrer, Konstantin M J, de Oliveira Mann, Carina C, Moldt, Manuela, Patel, Jenish R, Goldeck, Marion, Hartmann, Gunther, García-Sastre, Adolfo, Hornung, Veit, Conzelmann, Karl-Klaus, Beckmann, Roland, Hopfner, Karl-Peter

“…The cytosolic antiviral innate immune sensor RIG-I distinguishes 5' tri- or diphosphate containing viral double-stranded (ds) RNA from self-RNA by an…”
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Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA by Lässig, Charlotte, Matheisl, Sarah, Sparrer, Konstantin Mj, de Oliveira Mann, Carina C, Moldt, Manuela, Patel, Jenish R, Goldeck, Marion, Hartmann, Gunther, García-Sastre, Adolfo, Hornung, Veit, Conzelmann, Karl-Klaus, Beckmann, Roland, Hopfner, Karl-Peter

“…ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. eLife 4:e10859. doi: 10.7554/eLife.10859. During the revision of…”
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Structural basis for ATP-dependent chromatin remodelling by the INO80 complex by Eustermann, Sebastian, Schall, Kevin, Kostrewa, Dirk, Lakomek, Kristina, Strauss, Mike, Moldt, Manuela, Hopfner, Karl-Peter

“…In the eukaryotic nucleus, DNA is packaged in the form of nucleosomes, each of which comprises about 147 base pairs of DNA wrapped around a histone protein…”
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Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling by Zhang, Min, Jungblut, Anna, Kunert, Franziska, Hauptmann, Luis, Hoffmann, Thomas, Kolesnikova, Olga, Metzner, Felix, Moldt, Manuela, Weis, Felix, DiMaio, Frank, Hopfner, Karl-Peter, Eustermann, Sebastian

“…Loss of H2A-H2B histone dimers is a hallmark of actively transcribed genes, but how the cellular machinery functions in the context of noncanonical nucleosomal…”
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Structural basis for nucleosome remodeling by the INO80 complex by Eustermann, Sebastian, Schall, Kevin, Kostrewa, Dirk, Lakomek, Kristina, Strauss, Mike, Moldt, Manuela, Hopfner, Karl-Peter

“…DNA in the eukaryotic nucleus is packaged in the form of nucleosomes, ~147 base pairs of DNA wrapped around a histone protein octamer. The position and histone…”
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The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling by Civril, Filiz, Bennett, Matthew, Moldt, Manuela, Deimling, Tobias, Witte, Gregor, Schiesser, Stefan, Carell, Thomas, Hopfner, Karl-Peter

“…RIG‐I detects cytosolic viral dsRNA with 5′ triphosphates (5′‐ppp‐dsRNA), thereby initiating an antiviral innate immune response. Here we report the crystal…”
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Single‐molecule nucleosome remodeling by INO80 and effects of histone tails by Schwarz, Marianne, Schall, Kevin, Kallis, Eleni, Eustermann, Sebastian, Guariento, Mara, Moldt, Manuela, Hopfner, Karl‐Peter, Michaelis, Jens

“…Genome maintenance and integrity requires continuous alterations of the compaction state of the chromatin structure. Chromatin remodelers, among others the…”
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Single‐molecule nucleosome remodeling by INO 80 and effects of histone tails by Schwarz, Marianne, Schall, Kevin, Kallis, Eleni, Eustermann, Sebastian, Guariento, Mara, Moldt, Manuela, Hopfner, Karl‐Peter, Michaelis, Jens

“…Genome maintenance and integrity requires continuous alterations of the compaction state of the chromatin structure. Chromatin remodelers, among others the INO…”
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Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP by Wollmann, Petra, Cui, Sheng, Viswanathan, Ramya, Berninghausen, Otto, Wells, Melissa N., Moldt, Manuela, Witte, Gregor, Butryn, Agata, Wendler, Petra, Beckmann, Roland, Auble, David T., Hopfner, Karl-Peter

“…Remodelling transcription The Swi2/Snf2 family of proteins uses the energy of ATP hydrolysis to disrupt protein-DNA interactions, a process known as…”
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Structural mechanism of extranucleosomal DNA readout by the INO80 complex by Kunert, Franziska, Metzner, Felix J, Jung, James, Höpfler, Markus, Woike, Stephan, Schall, Kevin, Kostrewa, Dirk, Moldt, Manuela, Chen, Jia-Xuan, Bantele, Susanne, Pfander, Boris, Eustermann, Sebastian, Hopfner, Karl-Peter

“…The nucleosomal landscape of chromatin depends on the concerted action of chromatin remodelers. The INO80 remodeler specifically places nucleosomes at the…”
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Structural mechanism of cytosolic DNA sensing by cGAS by Civril, Filiz, Deimling, Tobias, de Oliveira Mann, Carina C, Ablasser, Andrea, Moldt, Manuela, Witte, Gregor, Hornung, Veit, Hopfner, Karl-Peter

“…Cytosolic DNA arising from intracellular bacterial or viral infections is a powerful pathogen-associated molecular pattern (PAMP) that leads to innate immune…”
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Structure and mechanism of the Swi2/Snf2 remodeller Motl in complex with its substrate TBP by Wollmann, Petra, Cui, Sheng, Viswanathan, Ramya, Berninghausen, Otto, Wells, Melissa N, Moldt, Manuela, Witte, Gregor, Butryn, Agata, Wendler, Petra, Beckmann, Roland, Auble, David T, Hopfner, Karl-Peter

“…Swi2/Snf2-type ATPases regulate genome-associated processes such as transcription, replication and repair by catalysing the disruption, assembly or remodelling…”
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Structure and mechanism of the Swi2/Snf2 remodeler Mot1 in complex with its substrate TBP by Wollmann, Petra, Cui, Sheng, Viswanathan, Ramya, Berninghausen, Otto, Wells, Melissa N., Moldt, Manuela, Witte, Gregor, Butryn, Agata, Wendler, Petra, Beckmann, Roland, Auble, David T., Hopfner, Karl-Peter

“…Swi2/Snf2-type ATPases broadly regulate genome-associated processes such as transcription, replication and repair by catalyzing disruption, assembly, or…”
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