Search Results - "Molderings, G"

White matter abnormalities are also repeatedly present in patients with systemic mast cell activation syndrome by Haenisch, B, Molderings, GJ

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Serotonin and beyond—a tribute to Manfred Göthert (1939-2019) by Bönisch, H., Fink, K. B., Malinowska, B., Molderings, G. J., Schlicker, E.

“…Manfred Göthert, who had served Naunyn-Schmiedeberg’s Arch Pharmacol as Managing Editor from 1998 to 2005, deceased in June 2019. His scientific oeuvre…”
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Cystic diseases in urology : Recommendations for patients with systemic mast cell disease by Knüpfer, H E, Keppler, V, Zienkiewicz, T, Molderings, G J

“…The systemic mast cell disease (MCAD; prevalence 17%) may occur frequently in urological patients. MCAD-induced changes include cysts in all organs, also in…”
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Direct inhibition by cannabinoids of human 5‐HT3A receptors: probable involvement of an allosteric modulatory site by Barann, M, Molderings, G, Brüss, M, Bönisch, H, Urban, B W, Göthert, M

“…Excised outside‐out patches from HEK293 cells stably transfected with the human (h) 5‐HT3A receptor cDNA were used to determine the effects of cannabinoid…”
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Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness by Molderings, G. J., Dumoulin, F. L., Homann, J., Sido, B., Textor, J., Mücke, M., Qagish, G. J., Barion, R., Raithel, M., Klingmüller, D., Schäfer, V. S., Hertfelder, H. J., Berdel, D., Tridente, G., Weinstock, L. B., Afrin, L. B.

“…Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study…”
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The transcriptome of the human mast cell leukemia cells HMC-1.2: an approach to identify specific changes in the gene expression profile in KitD816V systemic mastocytosis by Haenisch, B., Herms, S., Molderings, G. J.

“…To circumvent the costly isolation procedure associated with tissue mast cells, human mast cell lines such as HMC-1 are employed in mastocytosis research, but…”
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Molecular basis for the antiproliferative effect of agmatine in tumor cells of colonic, hepatic, and neuronal origin by Wolf, C, Brüss, M, Hänisch, B, Göthert, M, von Kügelgen, I, Molderings, G J

“…The aim of the present study was to challenge potential mechanisms of action underlying the inhibition of tumor cell proliferation by agmatine. Agmatine…”
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Evidence for mast cell activation in patients with therapy-resistant irritable bowel syndrome by Frieling, T, Meis, K, Kolck, U W, Homann, J, Hülsdonk, A, Haars, U, Hertfelder, H-J, Oldenburg, J, Seidel, H, Molderings, G J

“…Previous findings suggested an involvement of mast cells in the pathogenesis of irritable bowel syndrome (IBS). The pathophysiological significance of mast…”
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N-type calcium channels control sympathetic neurotransmission in human heart atrium by MOLDERINGS, G. J, LIKUNGU, J, GÖTHERT, M

“…Because knowledge about the type of calcium channels involved in action potential-induced norepinephrine release from the human peripheral sympathetic nervous…”
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The measurement of leukotrienes in urine as diagnostic option in systemic mastocytosis by Raithel, M, Zopf, Y, Kimpel, S, Naegel, A, Molderings, G J, Buchwald, F, Schultis, H W, Kressel, J, Hahn, E G, Konturek, P

“…Clinical symptoms of patients with mastocytosis may include skin reactions, but also gastrointestinal symptoms with hyperacidity and dysmotility (e.g. ulcer,…”
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Bleeding diathesis in patients with mast cell activation disease by Seidel, H, Molderings, G J, Oldenburg, J, Meis, K, Kolck, U W, Homann, J, Hertfelder, H-J

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Altered adrenergic responsiveness of endothelium-denuded hepatic arteries and portal veins in patients with cirrhosis by Heller, Jörg, Schepke, Michael, Gehnen, Nina, Molderings ‡, Gerhard J., Müller §, Andreas, Erhard ∥, Jochen, Spengler, Ulrich, Sauerbruch, Tilman

“…Background & Aims: Patients with cirrhosis are characterized by a reduced splanchnic vascular resistance and a hyporeactivity to adrenergic vasoconstrictors…”
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Presynaptic imidazoline receptors and non‐adrenoceptor[3H]‐idazoxan binding sites in human cardiovascular tissues by Molderings, G. J., Likungu, J., Jakschik, J., Göthert, M.

“…1 In segments of human right atrial appendages and pulmonary arteries preincubated with [3H]‐noradrenaline and superfused with physiological salt solution…”
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Pharmacological characteristics of the specific transporter for the endogenous cell growth inhibitor agmatine in six tumor cell lines by HEINEN, A, BRÜSS, M, BÖNISCH, H, GÖTHERT, M, MOLDERINGS, G. J

“…This study examined agmatine transport into six human intestinal tumor cell lines and compared the pharmacological properties of this transporter with those of…”
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Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship by Molderings, G J, Likungu, J, Göthert, M

“…Segments of human right atrial appendages preincubated with [3H]noradrenaline and superfused with physiological salt solution containing desipramine and…”
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Dual interaction of agmatine with the rat alpha(2D)-adrenoceptor: competitive antagonism and allosteric activation by Molderings, G J, Menzel, S, Kathmann, M, Schlicker, E, Göthert, M

“…In segments of rat vena cava preincubated with [(3)H]-noradrenaline and superfused with physiological salt solution, the influence of agmatine on the…”
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Agmatine and putrescine uptake in the human glioma cell line SK-MG-1 by Molderings, G J, Bönisch, H, Göthert, M, Brüss, M

“…The pharmacological properties of a specific agmatine uptake mechanism were investigated in the human glioma cell line SK-MG-1 and compared with those of the…”
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Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors by Schlicker, E, Fink, K, Molderings, G J, Price, G W, Duckworth, M, Gaster, L, Middlemiss, D N, Zentner, J, Likungu, J, Göthert, M

“…Human cerebral cortical slices and synaptosomes, guinea-pig cerebral cortical slices and human right atrial appendages were used to study the effects of…”
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Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors by Cubeddu, L X, Bönisch, H, Göthert, M, Molderings, G, Racké, K, Ramadori, G, Miller, K J, Schwörer, H

“…Nearly 30% of patients treated with metformin experience gastrointestinal side effects. Since release of 5-hydroxytryptamine (5-HT) from the intestine is…”
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Presynaptic Imidazoline Receptors: New Developments in Characterization and Classification by GÖTHERT, M., BRÜSS, M., BÖNISCH, H., MOLDERINGS, G. J.

“…Presynaptic imidazoline receptors (IRs) which inhibit norepinephrine (NE) release from sympathetic nerve endings have been identified in cardiovascular tissue…”
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