Search Results - "Moldawer, Lyle L."

Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome by Mira, Juan C., Gentile, Lori F., Mathias, Brittany J., Efron, Philip A., Brakenridge, Scott C., Mohr, Alicia M., Moore, Frederick A., Moldawer, Lyle L.

“…OBJECTIVES:To provide an appraisal of the evolving paradigms in the pathophysiology of sepsis and propose the evolution of a new phenotype of critically ill…”
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Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559) by Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Angus, Derek C., Moldawer, Lyle L., Crouser, Elliott D., Martin, Greg S., Coopersmith, Craig M., Brakenridge, Scott, Mayr, Florian B., Park, Pauline K., Ye, June, Catlett, Ian M., Girgis, Ihab G., Grasela, Dennis M.

“…OBJECTIVES:To assess for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 immune checkpoint inhibitor (BMS-936559;…”
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Murine Models of Sepsis and Trauma: Can We Bridge the Gap? by Stortz, Julie A., Raymond, Steven L., Mira, Juan C., Moldawer, Lyle L., Mohr, Alicia M., Efron, Philip A.

“…Abstract Sepsis and trauma are both leading causes of death in the United States and represent major public health challenges. Murine models have largely been…”
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Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome by Hawkins, Russell B, Raymond, Steven L, Stortz, Julie A, Horiguchi, Hiroyuki, Brakenridge, Scott C, Gardner, Anna, Efron, Philip A, Bihorac, Azra, Segal, Mark, Moore, Frederick A, Moldawer, Lyle L

“…Dysregulated host immune responses to infection often occur, leading to sepsis, multiple organ failure, and death. Some patients rapidly recover from sepsis,…”
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Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab by Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Crouser, Elliott D., Martin, Greg S., Albertson, Timothy, Bartz, Raquel R., Brakenridge, Scott C., Delano, Matthew J., Park, Pauline K., Donnino, Michael W., Tidswell, Mark, Mayr, Florian B., Angus, Derek C., Coopersmith, Craig M., Moldawer, Lyle L., Catlett, Ian M., Girgis, Ihab G., Ye, June, Grasela, Dennis M.

“…Purpose Sepsis-associated immunosuppression increases hospital-acquired infection and viral reactivation risk. A key underlying mechanism is programmed cell…”
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Persistent Inflammation, Immunosuppression and Catabolism Syndrome by Mira, Juan C., MD, Brakenridge, Scott C., MD, MS, Moldawer, Lyle L., PhD, Moore, Frederick A., MD, MCCM

“…Following advances in critical care, in-hospital multiple organ failure–related mortality is declining. Consequently, incidence of chronic critical illness is…”
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Mice are not men by Warren, H. Shaw, Tompkins, Ronald G., Moldawer, Lyle L., Seok, Junhee, Xu, Weihong, Mindrinos, Michael N., Maier, Ronald V., Xiao, Wenzhong, Davis, Ronald W.

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Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis by Hollen, McKenzie K, Stortz, Julie A, Darden, Dijoia, Dirain, Marvin L, Nacionales, Dina C, Hawkins, Russell B, Cox, Michael C, Lopez, Maria-Cecilia, Rincon, Jaimar C, Ungaro, Ricardo, Wang, Zhongkai, Wu, Quran, Brumback, Babette, Gauthier, Marie-Pierre L, Kladde, Michael, Leeuwenburgh, Christiaan, Segal, Mark, Bihorac, Azra, Brakenridge, Scott, Moore, Frederick A, Baker, Henry V, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A

“…Sepsis is an increasingly significant challenge throughout the world as one of the major causes of patient morbidity and mortality. Central to the host…”
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Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients by Stortz, Julie A, Mira, Juan C, Raymond, Steven L, Loftus, Tyler J, Ozrazgat-Baslanti, Tezcan, Wang, Zhongkai, Ghita, Gabriela L, Leeuwenburgh, Christiaan, Segal, Mark S, Bihorac, Azra, Brumback, Babette A, Mohr, Alicia M, Efron, Philip A, Moldawer, Lyle L, Moore, Frederick A, Brakenridge, Scott C

“…A growing number of patients survive sepsis but remain chronically critically ill. We sought to define clinical outcomes and incidence of chronic critical…”
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Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection by Polcz, Valerie E, Barrios, Evan L, Chapin, Benjamin, Price, Catherine C, Nagpal, Ravinder, Chakrabarty, Paramita, Casadesus, Gemma, Foster, Thomas, Moldawer, Lyle L, Efron, Philip A

“…Sexual dimorphisms exist in multiple domains, from learning and memory to neurocognitive disease, and even in the immune system. Male sex has been associated…”
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The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients by Brakenridge, Scott C, Efron, Philip A, Stortz, Julie A, Ozrazgat-Baslanti, Teczan, Ghita, Gabriela, Wang, Zhongkai, Bihorac, Azra, Mohr, Alicia M, Brumback, Babette A, Moldawer, Lyle L, Moore, Frederick A

“…Advancing age is a strong risk factor for adverse outcomes across multiple disease processes. However, septic surgical and trauma patients are unique in that…”
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Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study by Balch, Jeremy A, Chen, Uan-I, Liesenfeld, Oliver, Starostik, Petr, Loftus, Tyler J, Efron, Philip A, Brakenridge, Scott C, Sweeney, Timothy E, Moldawer, Lyle L

“…Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may…”
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Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy by Horiguchi, Hiroyuki, Loftus, Tyler J, Hawkins, Russell B, Raymond, Steven L, Stortz, Julie A, Hollen, McKenzie K, Weiss, Brett P, Miller, Elizabeth S, Bihorac, Azra, Larson, Shawn D, Mohr, Alicia M, Brakenridge, Scott C, Tsujimoto, Hironori, Ueno, Hideki, Moore, Frederick A, Moldawer, Lyle L, Efron, Philip A

“…Clinical and technological advances promoting early hemorrhage control and physiologic resuscitation as well as early diagnosis and optimal treatment of sepsis…”
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DAMPs, PAMPs, and the origins of SIRS in bacterial sepsis by Gentile, Lori F, Moldawer, Lyle L

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Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study by Stortz, Julie A, Cox, Michael C, Hawkins, Russell B, Ghita, Gabriela L, Brumback, Babette A, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A, Brakenridge, Scott C, Moore, Frederick A

“…The role of site of infection in sepsis has been poorly characterized. Additionally, sepsis epidemiology has evolved. Early mortality has decreased, but many…”
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The impact of sarcopenia and acute muscle mass loss on long‐term outcomes in critically ill patients with intra‐abdominal sepsis by Cox, Michael C., Booth, Matthew, Ghita, Gabriela, Wang, Zhongkai, Gardner, Anna, Hawkins, Russell B., Darden, Dijoia B., Leeuwenburgh, Christiaan, Moldawer, Lyle L., Moore, Frederick A., Efron, Philip A., Anton, Steven, Brakenridge, Scott C.

“…Background Sarcopenia is a known risk factor for poor outcomes across many chronic diseases. The impact on outcomes of both pre‐existing sarcopenia and acute…”
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Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis by Loftus, Tyler J, Ungaro, Ricardo, Dirain, Marvin, Efron, Philip A, Mazer, Monty B, Remy, Kenneth E, Hotchkiss, Richard S, Zhong, Luer, Bacher, Rhonda, Starostik, Petr, Moldawer, Lyle L, Brakenridge, Scott C

“…Both severe SARS-CoV-2 infections and bacterial sepsis exhibit an immunological dyscrasia and propensity for secondary infections. The nature of the…”
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HMGB1 as a therapeutic target for sepsis: it's all in the timing by Gentile, Lori F, Moldawer, Lyle L

“…Morbidity and mortality from severe sepsis remain high, despite decades of research and improvements in intensive care unit (ICU) care. There have been over…”
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Dysregulated Immunity and Immunotherapy after Sepsis by Darden, Dijoia B, Kelly, Lauren S, Fenner, Brittany P, Moldawer, Lyle L, Mohr, Alicia M, Efron, Philip A

“…Implementation of protocolized surveillance, diagnosis, and management of septic patients, and of surgical sepsis patients in particular, is shown to result in…”
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Role of Toll-like receptors in the development of sepsis by Tsujimoto, Hironori, Ono, Satoshi, Efron, Philip A, Scumpia, Philip O, Moldawer, Lyle L, Mochizuki, Hidetaka

“…The outcome of sepsis and septic shock has not significantly improved in recent decades despite the development of numerous drugs and supportive care…”
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