Search Results - "Mold, Matthew"

Aluminium in human brain tissue: how much is too much? by Exley, Christopher, Mold, Matthew J.

“…A burgeoning body of research confirms and affirms the presence of aluminium in human brain tissue. Recently, the first data on aluminium content of brain…”
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The binding, transport and fate of aluminium in biological cells by Exley, Christopher, Mold, Matthew J.

“…Aluminium is the most abundant metal in the Earth's crust and yet, paradoxically, it has no known biological function. Aluminium is biochemically reactive, it…”
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Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action by Shardlow, Emma, Mold, Matthew, Exley, Christopher

“…Aluminium salts are by far the most commonly used adjuvants in vaccines. There are only two aluminium salts which are used in clinically-approved vaccines,…”
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Correction to: Aluminium in human brain tissue: how much is too much? by Exley, Christopher, Mold, Matthew J.

“…The authors declare…”
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Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin by Mold, Matthew J., Kumar, Manpreet, Chu, William, Exley, Christopher

“…Aluminium is biologically reactive and its ability to potentiate the immune response has driven its inclusion in both veterinary and human vaccines…”
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Correction to: Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin by Mold, Matthew J., Kumar, Manpreet, Chu, William, Exley, Christopher

“…After publication of our article, it has come to our attention that our Conflict of Interest statement should read…”
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Aluminium co-localises with Biondi ring tangles in Parkinson’s disease and epilepsy by Mold, Matthew John, Exley, Christopher

“…Aluminium is known to accumulate in neuropathological hallmarks. However, such has only tentatively been suggested in Biondi ring tangles. Owing to their…”
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Imaging of aluminium and amyloid β in neurodegenerative disease by Exley, Christopher, Mold, Matthew J.

“…Recent research has confirmed the presence of aluminium in human brain tissue. Quantitative analyses suggest increased brain aluminium content in a number of…”
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Intracellular tracing of amyloid vaccines through direct fluorescent labelling by Mold, Matthew, Kumar, Manpreet, Mirza, Ambreen, Shardlow, Emma, Exley, Christopher

“…Alzheimer’s disease is a debilitating neurodegenerative condition that progressively causes synaptic loss and major neuronal damage. Immunotherapy utilising Aβ…”
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Update on the Inactivation Procedures for the Vaccine Development Prospects of a New Highly Virulent RGNNV Isolate by Falco, Alberto, Bello-Perez, Melissa, Díaz-Puertas, Rocío, Mold, Matthew, Adamek, Mikolaj

“…Viral nervous necrosis (VNN) caused by the nervous necrosis virus (NNV) affects a broad range of primarily marine fish species, with mass mortality rates often…”
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CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease by Crivelli, Simone M., Luo, Qian, Stevens, Jo A.A., Giovagnoni, Caterina, van Kruining, Daan, Bode, Gerard, den Hoedt, Sandra, Hobo, Barbara, Scheithauer, Anna-Lena, Walter, Jochen, Mulder, Monique T., Exley, Christopher, Mold, Matthew, Mielke, Michelle M., De Vries, Helga E., Wouters, Kristiaan, van den Hove, Daniel L. A., Berkes, Dusan, Ledesma, María Dolores, Verhaagen, Joost, Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar

“…Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide…”
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Serum amyloid P component accelerates the formation and enhances the stability of amyloid fibrils in a physiologically significant under-saturated solution of amyloid-β42 by Mold, Matthew, Shrive, Annette K, Exley, Christopher

“…The mechanism whereby an under-saturated solution of amyloid-β (Aβ)42 precipitates as β sheets in vivo in Alzheimer's disease remains to be elucidated. Herein…”
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Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations by Mold, Matthew, Shardlow, Emma, Exley, Christopher

“…Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) of…”
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Copper prevents amyloid-β1–42 from forming amyloid fibrils under near-physiological conditions in vitro by Mold, Matthew, Ouro-Gnao, Larissa, Wieckowski, Beata M, Exley, Christopher

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Aluminium in brain tissue in autism by Mold, Matthew, Umar, Dorcas, King, Andrew, Exley, Christopher

“…Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental…”
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The interaction of aluminium-based adjuvants with THP-1 macrophages in vitro: Implications for cellular survival and systemic translocation by Shardlow, Emma, Mold, Matthew, Exley, Christopher

“…Within clinical vaccinations, recombinant antigens are routinely entrapped inside or adsorbed onto the surface of aluminium salts in order to increase their…”
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Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford by Mold, Matthew, Cottle, Jason, Exley, Christopher

“…(1) Introduction: Human exposure to aluminium is a burgeoning problem. In 1988, the population of the Cornish town of Camelford was exposed to exceedingly high…”
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Aluminum and Amyloid-β in Familial Alzheimer's Disease by Mold, Matthew, Linhart, Caroline, Gómez-Ramírez, Johana, Villegas-Lanau, Andrés, Exley, Christopher

“…Genetic predispositions associated with metabolism of the amyloid-β protein precursor underlie familial Alzheimer's disease; a form of dementia characterized…”
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RE: Nies, I., Hidalgo, K., Bondy, S. C., & Campbell, A. (2020). Distinctive cellular response to aluminum based adjuvants. Environmental Toxicology and Pharmacology, 103404 by Shardlow, Emma, Mold, Matthew, Exley, Christopher

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Self-plasticized, lumogallion-based fluorescent optical sensor for the determination of aluminium (III) with ultra-low detection limits by Mendecki, Lukasz, Granados-Focil, Sergio, Jendrlin, Martin, Mold, Matthew, Radu, Aleksandar

“…Aluminium-selective ion optical sensor based on covalently attached lumogallion methacrylate was synthesized and investigated in this study. Lumogallion based…”
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