Search Results - "Mold, Jeff"

Comparison of whole genome amplification techniques for human single cell exome sequencing by Borgström, Erik, Paterlini, Marta, Mold, Jeff E, Frisen, Jonas, Lundeberg, Joakim

“…Whole genome amplification (WGA) is currently a prerequisite for single cell whole genome or exome sequencing. Depending on the method used the rate of…”
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The Lifespan and Turnover of Microglia in the Human Brain by Réu, Pedro, Khosravi, Azadeh, Bernard, Samuel, Mold, Jeff E., Salehpour, Mehran, Alkass, Kanar, Perl, Shira, Tisdale, John, Possnert, Göran, Druid, Henrik, Frisén, Jonas

“…The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of…”
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Cell generation dynamics underlying naive T-cell homeostasis in adult humans by Mold, Jeff E, Réu, Pedro, Olin, Axel, Bernard, Samuel, Michaëlsson, Jakob, Rane, Sanket, Yates, Andrew, Khosravi, Azadeh, Salehpour, Mehran, Possnert, Göran, Brodin, Petter, Frisén, Jonas

“…Thymic involution and proliferation of naive T cells both contribute to shaping the naive T-cell repertoire as humans age, but a clear understanding of the…”
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Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production by Lowe, Margaret M, Mold, Jeff E, Kanwar, Bittoo, Huang, Yong, Louie, Alexander, Pollastri, Michael P, Wang, Cuihua, Patel, Gautam, Franks, Diana G, Schlezinger, Jennifer, Sherr, David H, Silverstone, Allen E, Hahn, Mark E, McCune, Joseph M

“…The aryl hydrocarbon receptor (AHR) binds to environmental toxicants including synthetic halogenated aromatic hydrocarbons and is involved in a diverse array…”
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Antibody-secreting plasma cells persist for decades in human intestine by Landsverk, Ole J B, Snir, Omri, Casado, Raquel Bartolomé, Richter, Lisa, Mold, Jeff E, Réu, Pedro, Horneland, Rune, Paulsen, Vemund, Yaqub, Sheraz, Aandahl, Einar Martin, Øyen, Ole M, Thorarensen, Hildur Sif, Salehpour, Mehran, Possnert, Göran, Frisén, Jonas, Sollid, Ludvig M, Baekkevold, Espen S, Jahnsen, Frode L

“…Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been…”
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Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA–seq by Reinius, Björn, Mold, Jeff E, Ramsköld, Daniel, Deng, Qiaolin, Johnsson, Per, Michaëlsson, Jakob, Frisén, Jonas, Sandberg, Rickard

“…Rickard Sandberg and colleagues use allele-sensitive single-cell RNA–seq on primary mouse fibroblasts and human T cells to study clonal and dynamic monoallelic…”
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Integrative spatial and genomic analysis of tumor heterogeneity with Tumoroscope by Shafighi, Shadi, Geras, Agnieszka, Jurzysta, Barbara, Sahaf Naeini, Alireza, Filipiuk, Igor, Ra̧czkowska, Alicja, Toosi, Hosein, Koperski, Łukasz, Thrane, Kim, Engblom, Camilla, Mold, Jeff E., Chen, Xinsong, Hartman, Johan, Nowis, Dominika, Carbone, Alessandra, Lagergren, Jens, Szczurek, Ewa

“…Spatial and genomic heterogeneity of tumors are crucial factors influencing cancer progression, treatment, and survival. However, a technology for direct…”
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Activation of a neural stem cell transcriptional program in parenchymal astrocytes by Magnusson, Jens P, Zamboni, Margherita, Santopolo, Giuseppe, Mold, Jeff E, Barrientos-Somarribas, Mauricio, Talavera-Lopez, Carlos, Andersson, Björn, Frisén, Jonas

“…Adult neural stem cells, located in discrete brain regions, generate new neurons throughout life. These stem cells are specialized astrocytes, but astrocytes…”
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Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis by Rydén, Mikael, Uzunel, Mehmet, Hård, Joanna L., Borgström, Erik, Mold, Jeff E., Arner, Erik, Mejhert, Niklas, Andersson, Daniel P., Widlund, Yvonne, Hassan, Moustapha, Jones, Christina V., Spalding, Kirsty L., Svahn, Britt-Marie, Ahmadian, Afshin, Frisén, Jonas, Bernard, Samuel, Mattsson, Jonas, Arner, Peter

“…Because human white adipocytes display a high turnover throughout adulthood, a continuous supply of precursor cells is required to maintain adipogenesis. Bone…”
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Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood by Brownlie, Demi, Scharenberg, Marlena, Mold, Jeff E., Hård, Joanna, Kekäläinen, Eliisa, Buggert, Marcus, Nguyen, Son, Wilson, Jennifer N., Al-Ameri, Mamdoh, Ljunggren, Hans-Gustaf, Marquardt, Nicole, Michaëlsson, Jakob

“…Human adaptive-like “memory” CD56dimCD16⁺ natural killer (NK) cells in peripheral blood from cytomegalovirus-seropositive individuals have been extensively…”
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Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans by Mold, Jeff E, Venkatasubrahmanyam, Shivkumar, Burt, Trevor D, Michaëlsson, Jakob, Rivera, Jose M, Galkina, Sofiya A, Weinberg, Kenneth, Stoddart, Cheryl A, McCune, Joseph M

“…Although the mammalian immune system is generally thought to develop in a linear fashion, findings in avian and murine species argue instead for the…”
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Probabilistic count matrix factorization for single cell expression data analysis by Durif, Ghislain, Modolo, Laurent, Mold, Jeff E, Lambert-Lacroix, Sophie, Picard, Franck

“…Abstract Motivation The development of high-throughput single-cell sequencing technologies now allows the investigation of the population diversity of cellular…”
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Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics by Engblom, Camilla, Thrane, Kim, Lin, Qirong, Andersson, Alma, Toosi, Hosein, Chen, Xinsong, Steiner, Embla, Lu, Chang, Mantovani, Giulia, Hagemann-Jensen, Michael, Saarenpää, Sami, Jangard, Mattias, Saez-Rodriguez, Julio, Michaëlsson, Jakob, Hartman, Johan, Lagergren, Jens, Mold, Jeff E, Lundeberg, Joakim, Frisén, Jonas

“…The spatial distribution of lymphocyte clones within tissues is critical to their development, selection, and expansion. We have developed spatial…”
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Long-read whole-genome analysis of human single cells by Hård, Joanna, Mold, Jeff E., Eisfeldt, Jesper, Tellgren-Roth, Christian, Häggqvist, Susana, Bunikis, Ignas, Contreras-Lopez, Orlando, Chin, Chen-Shan, Nordlund, Jessica, Rubin, Carl-Johan, Feuk, Lars, Michaëlsson, Jakob, Ameur, Adam

“…Long-read sequencing has dramatically increased our understanding of human genome variation. Here, we demonstrate that long-read technology can give new…”
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Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero by Mold, Jeff E, Michaëlsson, Jakob, Burt, Trevor D, Muench, Marcus O, Beckerman, Karen P, Busch, Michael P, Lee, Tzong-Hae, Nixon, Douglas F, McCune, Joseph M

“…As the immune system develops, T cells are selected or regulated to become tolerant of self antigens and reactive against foreign antigens. In mice, the…”
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Immunological tolerance during fetal development: from mouse to man by Mold, Jeff E, McCune, Joseph M

“…The development of the adaptive immune system has been studied in the mouse primarily because it is easier to access fetal tissues and because there exists a…”
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Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease by Favre, David, Mold, Jeff, Hunt, Peter W, Kanwar, Bittoo, Loke, P'ng, Seu, Lillian, Barbour, Jason D, Lowe, Margaret M, Jayawardene, Anura, Aweeka, Francesca, Huang, Yong, Douek, Daniel C, Brenchley, Jason M, Martin, Jeffrey N, Hecht, Frederick M, Deeks, Steven G, McCune, Joseph M

“…The pathogenesis of human and simian immunodeficiency viruses is characterized by CD4(+) T cell depletion and chronic T cell activation, leading ultimately to…”
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High dimensional classification with combined adaptive sparse PLS and logistic regression by Durif, Ghislain, Modolo, Laurent, Michaelsson, Jakob, Mold, Jeff E, Lambert-Lacroix, Sophie, Picard, Franck

“…Abstract Motivation The high dimensionality of genomic data calls for the development of specific classification methodologies, especially to prevent…”
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Regulation of T Cell Responses in the Developing Human Fetus by Michaelsson, Jakob, Mold, Jeff E, McCune, Joseph M, Nixon, Douglas F

“…Although human T cells enter the peripheral lymphoid tissues early during fetal development, the adaptive immune system in the fetus has largely been regarded…”
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Identifying T Cell Receptors from High-Throughput Sequencing: Dealing with Promiscuity in TCRα and TCRβ Pairing by Lee, Edward S, Thomas, Paul G, Mold, Jeff E, Yates, Andrew J

“…Characterisation of the T cell receptors (TCR) involved in immune responses is important for the design of vaccines and immunotherapies for cancer and…”
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