Search Results - "Molchan, S E"

A Functional Anatomical Study of Associative Learning in Humans by Molchan, Susan E., Sunderland, Trey, McIntosh, A. R., Herscovitch, Peter, Schreurs, Bernard G.

“…The purpose of the study was to map the functional neuroanatomy of simple associative learning in humans. Eyeblink conditioning was studied in eight normal…”
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Differential cholinergic regulation in Alzheimer's patients compared to controls following chronic blockade with scopolamine : a SPECT study by SUNDERLAND, T, EXPOSITO, G, MOLCHAN, S. E, COPPOLA, R, JONES, D. W, GOREY, J, LITTLE, J. T, BAHRO, M, WEINBERGER, D. R

“…The effects of low-dose chronic scopolamine on measures of cerebral perfusion and muscarinic receptors were tested in eight Alzheimer's disease (AD) subjects…”
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The effects of scopolamine, lorazepam, and glycopyrrolate on classical conditioning of the human eyeblink response by BAHRO, M, SCHREURS, B. G, SUNDERLAND, T, MOLCHAN, S. E

“…Human eyeblink conditioning, a relatively simple form of learning and memory, has previously been shown to be impaired by the central and peripheral…”
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Pharmacologic challenges in Alzheimer disease and normal controls: cognitive modeling in humans by Sunderland, T, Molchan, S E, Little, J T, Bahro, M, Putnam, K T, Weingartner, H

“…Alzheimer disease (AD) is a progressive disorder characterized by cognitive and behavioral dysfunction, central to which are deficits in the cholinergic and…”
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Autonomic dysfunction in patients with dementia of the Alzheimer type by Vitiello, B, Veith, R C, Molchan, S E, Martinez, R A, Lawlor, B A, Radcliffe, J, Hill, J L, Sunderland, T

“…Abnormalities of the noradrenergic system have been documented in the central nervous system of patients with dementia of the Alzheimer's type (DAT). To…”
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Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model by Molchan, S E, Martinez, R A, Hill, J L, Weingartner, H J, Thompson, K, Vitiello, B, Sunderland, T

“…18 older normal volunteers (mean age = 66.5 +/- 7.9 years) and 46 younger volunteers (mean age = 27.0 +/- 6.1 years) were administered the anticholinergic drug…”
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CSF somatostatin in Alzheimer's disease and major depression: relationship to hypothalamic-pituitary-adrenal axis and clinical measures by Molchan, S E, Hill, J L, Martinez, R A, Lawlor, B A, Mellow, A M, Rubinow, D R, Bissette, G, Nemeroff, C B, Sunderland, T

“…Patients with Alzheimer's disease (AD) and major depression have been shown to have overlapping clinical symptoms and biological markers, including decreased…”
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Minimal effects of dextroamphetamine on scopolamine-induced cognitive impairments in humans by Martinez, Rick, Molchan, Susan E., Lawlor, Brian A., Thompson, Karen, Martinson, Heidi, Latham, Georgia, Weingartner, Herbert, Sunderland, Trey

“…The central anticholinergic drug scopolamine has been used to model aspects of the memory impairment that occurs in Alzheimer's disease and in aging. To…”
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Regional cerebral glucose metabolism in autopsy-confirmed Creutzfeldt-Jakob disease by Matochik, J A, Molchan, S E, Zametkin, A J, Warden, D L, Sunderland, T, Cohen, R M

“…Regional cerebral glucose metabolism was measured in a 72-year-old man, with Creutzfeldt-Jakob disease (CJD), by positron emission tomography using…”
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The TRH stimulation test in Alzheimer's disease and major depression: relationship to clinical and CSF measures by Molchan, S E, Lawlor, B A, Hill, J L, Mellow, A M, Davis, C L, Martinez, R, Sunderland, T

“…A blunted thyroid-stimulating hormone (TSH) response to exogenous thyrotropin-releasing hormone (TRH) has been reported to occur consistently in patients with…”
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Reflections of the self: atypical misidentification and delusional syndromes in two patients with Alzheimer's disease by Molchan, S E, Martinez, R A, Lawlor, B A, Grafman, J H, Sunderland, T

“…Two patients with moderately severe AD, when asked directly, could identify their own images in a mirror, but also consistently misidentified their own…”
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The effects of scopolamine on changes in regional cerebral blood flow during classical conditioning of the human eyeblink response by Bahro, M, Molchan, S E, Sunderland, T, Herscovitch, P, Schreurs, B G

“…We examined the effects of scopolamine on the functional anatomy of classical conditioning of the human eyeblink response. Ten healthy young normal female…”
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Penetration of tacrine into cerebrospinal fluid in patients with Alzheimer's disease by GROTHE, D. R, PISCITELLI, S. C, DUKOFF, R, FULLERTON, T, SUNDERLAND, T, MOLCHAN, S. E

“…Tacrine is widely used for the treatment of Alzheimer's disease, but data are limited regarding cerebrospinal fluid (CSF) concentrations at steady state. To…”
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CSF monoamine metabolites and somatostatin in Alzheimer's disease and major depression by Molchan, S E, Lawlor, B A, Hill, J L, Martinez, R A, Davis, C L, Mellow, A M, Rubinow, D R, Sunderland, T

“…Decreased cerebrospinal fluid (CSF), somatostatinlike immunoreactivity (SLI) and alterations in the CSF monamine metabolites…”
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A preliminary study of the effects of nighttime administration of the serotonin agonist, m-CPP, on sleep architecture and behavior in healthy volunteers by Lawlor, B A, Newhouse, P A, Balkin, T J, Molchan, S E, Mellow, A M, Murphy, D L, Sunderland, T

“…The effects of m-chlorophenylpiperazine (m-CPP) (0.5 mg/kg) on sleep architecture and behavior were examined in six healthy volunteers following a single oral…”
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Decreased CSF inositol monophosphatase activity after lithium treatment by Molchan, S E, Atack, J R, Sunderland, T

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A double FDG/PET study of the effects of scopolamine in older adults by MOLCHAN, S. E, MATOCHIK, J. A, ZAMETKIN, A. J, SZYMANSKI, H. V, CANTILLON, M, COHEN, R. M, SUNDERLAND, T

“…Two consecutive positron emission scans were done in one session using a double injection method of [18F]2-fluoro-2-deoxyglucose administration to examine the…”
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Lateralization and Behavioral Correlation of Changes in Regional Cerebral Blood Flow With Classical Conditioning of the Human Eyeblink Response by Schreurs, Bernard G, Mcintosh, Anthony R, Bahro, Marcel, Herscovitch, Peter, Sunderland, Trey, Molchan, Susan E

“…Bernard G. Schreurs 1 , Anthony R. Mcintosh 2 , Marcel Bahro 3 , Peter Herscovitch 4 , Trey Sunderland 3 , and Susan E. Molchan 3 1  Laboratory of Adaptive…”
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Effects of chronic lithium treatment on platelet PKC isozymes in Alzheimer's and elderly control subjects by Molchan, S E, Manji, H, Chen, G, Dou, L, Little, J, Potter, W Z, Sunderland, T

“…Patients with Alzheimer's disease (AD) have been reported to have abnormalities in peripheral cells similar to some of those found in the brain, including…”
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Scopolamine effects on the pressor response to thyrotropin-releasing hormone in humans by Molchan, S E, Hill, J L, Minichiello, M, Vitiello, B, Sunderland, T

“…Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic…”
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