High levels of soluble intercellular adhesion molecule-1 (ICAM-1) in crevicular fluid of periodontitis patients with plaque

. The intercellular adhesion tnolecule‐1 (ICAM‐1) is a membrane‐bound molecule involved in cell‐cell adhesive interactions which is upregulated on inflammatory epithelial cells. The levels of soluble ICAM‐1 (sICAM‐1) shed into the gingival crevicular fluid (GCF) were studied in healthy patients and...

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Bibliographic Details
Published in:	Journal of clinical periodontology Vol. 25; no. 9; pp. 754 - 758
Main Authors:	Molé, Nathalie, March, Anne Kennel-de, Martin, Gérard, Miller, Neal, Béné, Marie C., Faure, Gilbert C.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-09-1998
Subjects:	Adolescent Adult Aged Cell Adhesion Child Child, Preschool Dental Plaque - metabolism Dental Plaque Index Dentistry Enzyme-Linked Immunosorbent Assay Epithelial Cells - metabolism Epithelial Cells - pathology Extracellular Space - metabolism Female Gingiva - metabolism Gingiva - pathology gingival crevicular fluid Gingival Crevicular Fluid - chemistry Gingival Hemorrhage - metabolism gingivitis Gingivitis - metabolism Humans Intercellular Adhesion Molecule-1 - analysis Male Middle Aged Periodontal Index Periodontal Pocket - metabolism periodontitis Periodontitis - metabolism soluble ICAM-1 Up-Regulation
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Summary:	. The intercellular adhesion tnolecule‐1 (ICAM‐1) is a membrane‐bound molecule involved in cell‐cell adhesive interactions which is upregulated on inflammatory epithelial cells. The levels of soluble ICAM‐1 (sICAM‐1) shed into the gingival crevicular fluid (GCF) were studied in healthy patients and patients with gingivitis, adult periodontitis or rapidly progressive periodontitis, using an ELISA technique. Clinical parameters including plaque index, gingival index, probing depth, and bleeding on probing were recorded following careful sampling of GCF with standardised filter strips. In GCF, sICAM‐1 levels were higher for patients with plaque (p=0.04) and for patients with inflammation (p=0.02), but did not correlate with disease classifications. These results suggest that elevated GCF sICAM‐1 levels may represent increased shedding of this molecule in the interstitial fluid as a result of membrane‐bound ICAM‐1 upregulation on ICAM‐1 gingival‐bearing cells in relation with plaque accumulation and inflammation.
Bibliography:	ark:/67375/WNG-XSTRN05S-8 ArticleID:JCPE754 istex:BD8C5FB5BC7A11D0D516029C241A4E915677E77F ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0303-6979 1600-051X
DOI:	10.1111/j.1600-051X.1998.tb02517.x