Search Results - "Mokry, Lauren"

Obesity and Multiple Sclerosis: A Mendelian Randomization Study by Mokry, Lauren E, Ross, Stephanie, Timpson, Nicholas J, Sawcer, Stephen, Davey Smith, George, Richards, J Brent

“…Observational studies have reported an association between obesity, as measured by elevated body mass index (BMI), in early adulthood and risk of multiple…”
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Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study by Mokry, Lauren E, Ross, Stephanie, Ahmad, Omar S, Forgetta, Vincenzo, Smith, George Davey, Goltzman, David, Leong, Aaron, Greenwood, Celia M T, Thanassoulis, George, Richards, J Brent

“…Observational studies have demonstrated an association between decreased vitamin D level and risk of multiple sclerosis (MS); however, it remains unclear…”
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Genetically decreased vitamin D and risk of Alzheimer disease by Mokry, Lauren E, Ross, Stephanie, Morris, John A, Manousaki, Despoina, Forgetta, Vincenzo, Richards, J Brent

“…OBJECTIVE:To test whether genetically decreased vitamin D levels are associated with Alzheimer disease (AD) using mendelian randomization (MR), a method that…”
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Mendelian randomisation applied to drug development in cardiovascular disease: a review by Mokry, Lauren E, Ahmad, Omar, Forgetta, Vincenzo, Thanassoulis, George, Richards, J Brent

“…Despite increased expenditure, productivity of the pharmaceutical industry has decreased and currently 90% of developed molecules entering phase II and phase…”
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Mendelian Randomization Studies Do Not Support a Role for Vitamin D in Coronary Artery Disease by Manousaki, Despoina, Mokry, Lauren E, Ross, Stephanie, Goltzman, David, Richards, J Brent

“…BACKGROUND—Observational studies support a possible association between decreased vitamin D levels and risk of coronary artery disease (CAD); however, it…”
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Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study by Mokry, Lauren E., Zhou, Sirui, Guo, Cong, Scott, Robert A., Devey, Luke, Langenberg, Claudia, Wareham, Nick, Waterworth, Dawn, Cardon, Lon, Sanseau, Philippe, Davey Smith, George, Richards, J. Brent

“…Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug…”
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Vitamin D: Ten Beliefs by Mokry, Lauren E., Richards, J. Brent

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Polygenic risk for coronary heart disease acts through atherosclerosis in type 2 diabetes by Lu, Tianyuan, Forgetta, Vincenzo, Yu, Oriana H Y, Mokry, Lauren, Gregory, Madeline, Thanassoulis, George, Greenwood, Celia M T, Richards, J Brent

“…Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide an…”
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Large differences in adiponectin levels have no clear effect on multiple sclerosis risk: A Mendelian randomization study by Devorak, Julia, Mokry, Lauren E, Morris, John A, Forgetta, Vincenzo, Davey Smith, George, Sawcer, Stephen, Richards, J Brent

“…Background: Mendelian randomization (MR) studies have demonstrated strong support for an association between genetically increased body mass index and risk of…”
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Correction: Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study by Mokry, Lauren E, Ross, Stephanie, Ahmad, Omar S, Forgetta, Vincenzo, Smith, George Davey, Goltzman, David, Leong, Aaron, Greenwood, Celia M T, Thanassoulis, George, Richards, J Brent

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Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study by Trajanoska, Katerina, Morris, John A, Oei, Ling, Zheng, Hou-Feng, Evans, David M, Kiel, Douglas P, Ohlsson, Claes, Richards, J Brent, Rivadeneira, Fernando

“…AbstractObjectivesTo identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture…”
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Whole-exome sequencing identifies rare variants in STAB2 associated with venous thromboembolic disease by Desch, Karl C., Ozel, Ayse B., Halvorsen, Matt, Jacobi, Paula M., Golden, Krista, Underwood, Mary, Germain, Marine, Tregouet, David-Alexandre, Reitsma, Pieter H., Kearon, Clive, Mokry, Lauren, Richards, J. Brent, Williams, Frances, Li, Jun Z., Goldstein, David, Ginsburg, David

“…Deep vein thrombosis and pulmonary embolism, collectively defined as venous thromboembolism (VTE), are the third leading cause of cardiovascular death in the…”
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Exome Sequencing Studies Identify Mutations in STAB2 As a Genetic Risk for Venous Thromboembolic Disease by Desch, Karl, Ozel, Ayse Bilge, Halvorsen, Matthew, Michels, Alison L., Swystun, Laura L, Mokry, Lauren, Richards, Brent, Germain, Marine, Tregouet, David A., Reitsma, Pieter H., Kearon, Clive, Li, Jun Z, Goldstein, David B., Lillicrap, David, Ginsburg, David

“…Deep vein thrombosis and pulmonary embolism, collectively referred to as venous thromboembolism (VTE), are the third leading cause of cardiovascular death in…”
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Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study: e1001866 by Mokry, Lauren E, Ross, Stephanie, Ahmad, Omar S, getta, Vincenzo, Smith, George Davey, Leong, Aaron, Greenwood, Celia MT, Thanassoulis, George, Richards, J Brent

“…Background Observational studies have demonstrated an association between decreased vitamin D level and risk of multiple sclerosis (MS); however, it remains…”
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Using Mendelian Randomization to Elucidate the Role of Vitamin D in Multiple Sclerosis by Mokry, Lauren E

“…Background: Observational studies have long reported an association between decreased vitamin D and increased risk of multiple sclerosis (MS). However since it…”
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