Search Results - "Mokrosz, Jerzy L"

Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents by Strekowski, Lucjan, Mokrosz, Jerzy L, Honkan, Vidya A, Czarny, Agnieszka, Cegla, Marek T, Wydra, Roman L, Patterson, Steven E, Schinazi, Raymond F

“…Thirty-eight 2-(aryl or heteroaryl)quinolin-4-amines, N,N-disubstituted, N-monosubstituted, and without a substituent at the amino group have been synthesized…”
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Binding of unfused aromatic cations to DNA. The influence of molecular twist on intercalation by Wilson, W. David, Strekowski, Lucjan, Tanious, Farial A, Watson, Rebecca A, Mokrosz, Jerzy L, Strekowska, Alewtina, Webster, Gordon D, Neidle, Stephen

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Structure and spectral properties of β-carbolines. 8. Mechanism of the Pictet-Spengler cyclization: An MNDO approach by Kowalski, Piotr, Bojarski, Andrzej J, Mokrosz, Jerzy L

“…Formation of 1,2,3,4-tetrahydro-β-carboline in the Pictet-Spengler reaction was studied using an MNDO approach. It was shown that the formation of the…”
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8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl)]butyl]-8-azaspiro[4.5]decane-7,9-dione:  A New 5-HT1A Receptor Ligand with the Same Activity Profile as Buspirone by Mokrosz, Jerzy L, Dereń-Wesołek, Anna, Tatarczyńska, Ewa, Duszyńska, Beata, Bojarski, Andrzej J, Mokrosz, Maria J, Chojnacka-Wójcik, Ewa

“…A new analog of buspirone (1), i.e., 8-[4-[2-(1,2,3,4-tetrahydroisoquinolinyl)]butyl]-8-azaspiro[4.5]decane-7,9-dione (6a), was synthesized. In was…”
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Stereoelectronic factors in the interaction with DNA of small aromatic molecules substituted with a short cationic chain: Importance of the polarity of the aromatic system of the molecule by Strekowski, Lucjan, Mokrosz, Jerzy L, Wilson, W. David, Mokrosz, Maria J, Strekowski, Alewtina

“…We have performed a quantitative analysis of the interaction with DNA of several unfused aromatic compounds synthesized in our laboratory and substituted with…”
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Structure-activity relationship studies of central nervous system (CNS) agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor sites by Mokrosz, Jerzy L, Pietrasiewicz, Marzena, Duszynska, Beata, Cegla, Marek T

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Structure-Activity Relationship Studies of Central Nervous System Agents. 13.4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a New Putative 5-HT1A Receptor Antagonist, and Its Analogs by Mokrosz, Jerzy L, Paluchowska, Maria H, Chojnacka-Wojcik, Ewa, Filip, Malgorzata, Charakchieva-Minol, Sijka, Deren-Wesolek, Anna, Mokrosz, Maria J

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Quantitative structure-activity relationship analysis of cation-substituted polyaromatic compounds as potentiators (amplifiers) of bleomycin-mediated degradation of DNA by Strekowski, Lucjan, Wilson, W. David, Mokrosz, Jerzy L, Mokrosz, Maria J, Harden, Donald B, Tanious, Farial A, Wydra, Roman L, Crow, Sidney A

“…A set of 21 polyheteroaromatic compounds substituted with flexible cationic groups and of similar molecular size has been analyzed for binding with DNA and for…”
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Molecular basis for bleomycin amplification: conformational and stereoelectronic effects in unfused amplifiers by Strekowski, Lucjan, Mokrosz, Jerzy L, Tanious, Farial A, Watson, Rebecca A, Harden, Donald, Mokrosz, Maria, Edwards, W. Daniel, Wilson, W. David

“…Sixteen unfused heterobiaromatic and biphenyl compounds substituted with an amino side chain (protonated in water) have been tested for (i) binding with DNA…”
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Synthesis and stereochemistry of new trihydrodiazabicyclo-[3.m.n]alkano[4′,5′:1,2]pyrido[3,4-b]indole ring system by Misztal, Stanislaw, Paluchowska, Maria H., Mokrosz, Maria J., Bartyzel, Piotr, Mokrosz, Jerzy L.

“…The classical Pictet‐Spengler reaction of tryptamine with the isomeric N‐benzylpiperidones 3a, 3b and N‐benzylpyrrolidone 3c yielded the spiro derivatives of…”
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A biphasic nature of the bleomycin-mediated degradation of DNA by Strekowski, Lucjan, Mokrosz, Jerzy L., Wilson, W.David

“…The bleomycin-mediated digestion of DNA in the presence of ferrous ion, molecular oxygen, and dithiothreitol is characterized by a fast initial reaction, which…”
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Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs by Mokrosz, J L, Paluchowska, M H, Chojnacka-Wójcik, E, Filip, M, Charakchieva-Minol, S, Dereń-Wesołek, A, Mokrosz, M J

“…A new set of 4-alkyl-1-(o-methoxyphenyl)piperazines containing a terminal benzotriazole fragment were synthesized, and their 5-HT1A and 5-HT2 affinity was…”
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Structure-activity relationship studies of CNS agents--XVII. Spiro[piperidine-4',1-(1,2,3,4-tetrahydro-beta-carboline)] as a probe defining the extended topographic model of 5-HT1A receptors by Mokrosz, M J, Duszynska, B, Bojarski, A J, Mokrosz, J L

“…Spiro[piperidine-4',1-(1,2,3,4-tetrahydro-beta-carboline)] (10), its derivatives 11-15 and its analogs 16 and 17 were examined as ligands of serotonin 5-HT1A…”
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Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site by Mokrosz, J L, Pietrasiewicz, M, Duszyńska, B, Cegła, M T

“…The effect of the hydrocarbon chain of the model 4-substituted 1-(3-chlorophenyl)piperazines 12-31 on their affinity for 5-HT1A receptor sites was…”
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8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl)]butyl]-8-azaspiro[4.5]decane-7,9-dione:  A New 5-HT 1A Receptor Ligand with the Same Activity Profile as Buspirone by Mokrosz, Jerzy L., Dereń-Wesołek, Anna, Tatarczyńska, Ewa, Duszyńska, Beata, Bojarski, Andrzej J., Mokrosz, Maria J., Chojnacka-Wójcik, Ewa

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Structure-activity relationship studies of CNS agents-XVII. Spiro[piperidine-4′,1-(1,2,3,4-tetrahydro-β-carboline)] as a probe defining the extended topographic model of 5-HT 1A receptors by Mokrosz, Maria J., Duszynska, Beata, Bojarski, Andrzej J., Mokrosz, Jerzy L.

“…Spiro[piperidine-4′,1-(1,2,3,4-tetrahydro-β-carboline)] ( 10), its derivatives 11–15 and its analogs 16 and 17 were examined as ligands of serotonin 5-HT 1A…”
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3-(omega-Aminoalkyl)-5,5-dialkyl(or spirocycloalkyl-1',5-)hydantoins as new 5-HT1A and 5-HT2A receptor ligands by Byrtus, H, Pawłowski, M, Charakchieva-Minol, S, Duszyńska, B, Mokrosz, M J, Mokrosz, J L, Zejc, A

“…A series of new 3-(omega-aminoalkyl)-5,5-disubstituted hydantoins, containing 1-phenylpiperazine, 1-(o-methoxyphenyl)piperazine or…”
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Conformational analysis of 4-(2′-furyl)-2-(methylamino)pyrimidine by Mokrosz, Jerzy L., Bojarski, Andrzej J., Harden, Donald B., Strekowski, Lucjan

“…Conformational transformations of the title compound 1 were studied using high‐resolution 1H‐nmr techniques, semi‐empirical PM3 calculations and molecular…”
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Structure and Spectal Properties of b-Carbolines. Part 7. The Pictet-Spengler Reaction of Tryptamines with N-Benzyl-4-piperidone by L. Mokrosz, Jerzy, J. Mokrosz, Maria, Kowalski, Piotr, J. Bojarski, Andrzej

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Structure and Spectral Properties of b-Carbolines, Part 6. Regiooooselectivity of Cyclocondensation of Spiro[piperidine-m',1-(1,2,3,4-tetrahydeo-b-carbolines)] with Aldehydes by J. Mokorosz, Maria, J. Mokrosz, Maria, H. Paluchowska, Maria, Misztal, Stanislaw, L. Mokrosz, Jerzy

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