Search Results - "Mok, Myth TS"

Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro by Wang, Jia, Zhao, Jingmin, Chu, Eagle SH, Mok, Myth TS, Go, Minnie YY, Man, Kwan, Heuchel, Rainer, Lan, Hui Yao, Chang, Zhijie, Sung, Joseph JY, Yu, Jun

“…Smad7 is a principal inhibitor of the TGFβ–Smad signalling pathway. We have investigated the functional significance of Smad7 in hepatocellular carcinoma…”
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Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis by Wu, Feng, Xu, Liangliang, Tu, Yalin, Cheung, Otto KW, Szeto, Lemuel LM, Mok, Myth TS, Yang, Weiqin, Kang, Wei, Cao, Qin, Lai, Paul BS, Chan, Stephen L., Tan, Patrick, Sung, Joseph JY, Yip, Kevin Y., Cheng, Alfred SL, To, Ka F.

“…Hepatocellular carcinoma (HCC) is a major cancer burden worldwide with increasing incidence in many developed countries. Super-enhancers (SEs) drive gene…”
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CUL4B: a novel epigenetic driver in Wnt/[beta]-catenin-dependent hepatocarcinogenesis by Mok, Myth TS, Cheng, Alfred SL

“…Emerging evidence indicates that Cullin 4B (CUL4B), a major component of ubiquitin ligase complexes, is over-expressed in diverse cancer types with…”
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Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis by Lee, Ying-Ying, Mok, Myth TS, Kang, Wei, Yang, Weiqin, Tang, Wenshu, Wu, Feng, Xu, Liangliang, Yan, Mingfei, Yu, Zhuo, Lee, Sau-Dan, Tong, Joanna H M, Cheung, Yue-Sun, Lai, Paul B S, Yu, Dae-Yeul, Wang, Qianben, Wong, Grace L H, Chan, Andrew M, Yip, Kevin Y, To, Ka-Fai, Cheng, Alfred S L

“…Abstract Genomic sequencing of hepatocellular carcinoma (HCC) uncovers a paucity of actionable mutations, underscoring the necessity to exploit epigenetic…”
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Genotype/phenotype correlation in 123 Chinese patients with Tuberous Sclerosis Complex by Ng, Samuel YL, Luk, Ho-Ming, Hau, Edgar WL, Cheng, Shirley SW, Yu, Kris PT, Ho, Stephanie, Mok, Myth TS, Lo, Ivan FM

“…Tuberous Sclerosis Complex (TSC) is a multisystemic neurocutaneous disorder with autosomal dominant inheritance. We performed mutation analyses on 123 Chinese…”
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Old and new perspectives on Neurofibromatosis type 1: Clinical and molecular characterization of 832 patients from a single centre over 16 years by Ho, Stephanie KL, Luk, Ho-ming, Ng, Samuel YL, Yu, Kris PT, Cheng, Shirley SW, Ng, Phoebe PY, Mok, Myth TS, Hau, Edgar WL, Lo, Ivan FM

“…Neurofibromatosis type 1 (NF1; OMIM #162200) is the commonest multi-systemic neurocutaneous tumour-predisposition disorder. It has an age-related complete…”
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Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis by Zhu, Ranxu, Mok, Myth TS, Kang, Wei, Lau, Suki SK, Yip, Wing-Kit, Chen, Yangchao, Lai, Paul BS, Wong, Vincent WS, To, Ka-Fai, Sung, Joseph JY, Cheng, Alfred SL, Chan, Henry LY

“…Hepatocellular carcinoma (HCC) is a worldwide threat to public health, especially in China, where chronic hepatitis B virus (HBV) infection is found in 80–90%…”
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The ubiquitin ligases RNF8 and RNF168 display rapid but distinct dynamics at DNA repair foci in living cells by Mok, Myth T.S., Cheng, Alfred S.L., Henderson, Beric R.

“…Rapid assembly of DNA damage response (DDR) proteins at nuclear “repair” foci is a hallmark response of ionizing radiation (IR)-treated cells. The ubiquitin E3…”
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The In Vivo Dynamic Organization of BRCA1‐A Complex Proteins at DNA Damage‐Induced Nuclear Foci by Mok, Myth T.S., Henderson, Beric R.

“…The breast cancer associated gene 1 (BRCA1)‐A protein complex assembles at DNA damage‐induced nuclear foci to facilitate repair of double‐stranded breaks…”
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Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival by Brocardo, Mariana, Lei, Ying, Tighe, Anthony, Taylor, Stephen S, Mok, Myth T S, Henderson, Beric R

“…The adenomatous polyposis coli (APC) protein tumor suppressor is mutated in the majority of colon cancers. Most APC gene mutations cause deletion of the C…”
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Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants? by Lovelock, Paul K, Spurdle, Amanda B, Mok, Myth T S, Farrugia, Daniel J, Lakhani, Sunil R, Healey, Sue, Arnold, Stephen, Buchanan, Daniel, Couch, Fergus J, Henderson, Beric R, Goldgar, David E, Tavtigian, Sean V, Chenevix-Trench, Georgia, Brown, Melissa A

“…Many of the DNA sequence variants identified in the breast cancer susceptibility gene BRCA1 remain unclassified in terms of their potential pathogenicity. Both…”
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Kinetic and Physical Characterization of the Inducible UDP-N-acetylglucosamine Pyrophosphorylase from Giardia intestinalis by Mok, Myth T.S., Edwards, Michael R.

“…The UDP-N-acetylglucosamine pyrophosphorylase in Giardia intestinalis (GiUAP) is one of the five inducible enzymes to synthesize UDP-GalNAc, which is an…”
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