Search Results - "Mojica, Francisco J."

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants by Makarova, Kira S., Wolf, Yuri I., Iranzo, Jaime, Shmakov, Sergey A., Alkhnbashi, Omer S., Brouns, Stan J. J., Charpentier, Emmanuelle, Cheng, David, Haft, Daniel H., Horvath, Philippe, Moineau, Sylvain, Mojica, Francisco J. M., Scott, David, Shah, Shiraz A., Siksnys, Virginijus, Terns, Michael P., Venclovas, Česlovas, White, Malcolm F., Yakunin, Alexander F., Yan, Winston, Zhang, Feng, Garrett, Roger A., Backofen, Rolf, van der Oost, John, Barrangou, Rodolphe, Koonin, Eugene V.

“…The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of…”
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The discovery of CRISPR in archaea and bacteria by Mojica, Francisco J. M., Rodriguez‐Valera, Francisco

“…CRISPR‐Cas are self‐/nonself‐discriminating systems found in prokaryotic cells. They represent a remarkable example of molecular memory that is hereditarily…”
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Evolution and classification of the CRISPR–Cas systems by Koonin, Eugene V, Makarova, Kira S, Haft, Daniel H, Barrangou, Rodolphe, Brouns, Stan J. J, Charpentier, Emmanuelle, Horvath, Philippe, Moineau, Sylvain, Mojica, Francisco J. M, Wolf, Yuri I, Yakunin, Alexander F, van der Oost, John

“…The CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) systems are immunity systems that are present in many…”
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Complete genome sequence of Crohn's disease-associated adherent-invasive E. coli strain LF82 by Miquel, Sylvie, Peyretaillade, Eric, Claret, Laurent, de Vallée, Amélie, Dossat, Carole, Vacherie, Benoit, Zineb, El Hajji, Segurens, Beatrice, Barbe, Valerie, Sauvanet, Pierre, Neut, Christel, Colombel, Jean-Frédéric, Medigue, Claudine, Mojica, Francisco J M, Peyret, Pierre, Bonnet, Richard, Darfeuille-Michaud, Arlette

“…Ileal lesions of Crohn's disease (CD) patients are abnormally colonized by pathogenic adherent-invasive Escherichia coli (AIEC) able to invade and to replicate…”
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Reconstructing viral genomes from the environment using fosmid clones: the case of haloviruses by Garcia-Heredia, Inmaculada, Martin-Cuadrado, Ana-Belen, Mojica, Francisco J M, Santos, Fernando, Mira, Alex, Antón, Josefa, Rodriguez-Valera, Francisco

“…Metaviriomes, the viral genomes present in an environment, have been studied by direct sequencing of the viral DNA or by cloning in small insert libraries. The…”
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CRISPR Content Correlates with the Pathogenic Potential of Escherichia coli by García-Gutiérrez, Enriqueta, Almendros, Cristóbal, Mojica, Francisco J M, Guzmán, Noemí M, García-Martínez, Jesús

“…Guide RNA molecules (crRNA) produced from clustered regularly interspaced short palindromic repeat (CRISPR) arrays, altogether with effector proteins (Cas)…”
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Target motifs affecting natural immunity by a constitutive CRISPR-Cas system in Escherichia coli by Almendros, Cristóbal, Guzmán, Noemí M, Díez-Villaseñor, César, García-Martínez, Jesús, Mojica, Francisco J M

“…Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR associated (cas) genes conform the CRISPR-Cas systems of various bacteria and…”
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Leuconostoc mesenteroides and Leuconostoc pseudomesenteroides bacteriophages: Genomics and cross-species host ranges by Pujato, Silvina A., Guglielmotti, Daniela M., Martínez-García, Manuel, Quiberoni, Andrea, Mojica, Francisco J.M.

“…Unveiling virus-host interactions are relevant for understanding the biology and evolution of microbes globally, but in particular, it has also a paramount…”
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Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins by Alonso-Lerma, Borja, Jabalera, Ylenia, Samperio, Sara, Morin, Matias, Fernandez, Almudena, Hille, Logan T., Silverstein, Rachel A., Quesada-Ganuza, Ane, Reifs, Antonio, Fernández-Peñalver, Sergio, Benitez, Yolanda, Soletto, Lucia, Gavira, Jose A., Diaz, Adrian, Vranken, Wim, Sanchez-Mejias, Avencia, Güell, Marc, Mojica, Francisco J. M., Kleinstiver, Benjamin P., Moreno-Pelayo, Miguel A., Montoliu, Lluis, Perez-Jimenez, Raul

“…Clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9 is an effector protein that targets invading DNA and plays a major role in…”
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on-off switch of CRISPR immunity against phages in Escherichia coli by Mojica, Francisco J.M, Díez-Villaseñor, César

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Global phylogenomic novelty of the Cas1 gene from hot spring microbial communities by Salgado, Oscar, Guajardo-Leiva, Sergio, Moya-Beltrán, Ana, Barbosa, Carla, Ridley, Christina, Tamayo-Leiva, Javier, Quatrini, Raquel, Mojica, Francisco J M, Díez, Beatriz

“…The Cas1 protein is essential for the functioning of CRISPR-Cas adaptive systems. However, despite the high prevalence of CRISPR-Cas systems in thermophilic…”
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Next-generation precision antimicrobials: towards personalized treatment of infectious diseases by de la Fuente-Nunez, Cesar, Torres, Marcelo DT, Mojica, Francisco JM, Lu, Timothy K

“…Highlights • Precision antimicrobials represent a novel approach for treating infectious diseases. • The role of the microbiota in health and disease is…”
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Identification of the EH CRISPR‐Cas9 system on a metagenome and its application to genome engineering by Esquerra‐Ruvira, Belen, Baquedano, Ignacio, Ruiz, Raul, Fernandez, Almudena, Montoliu, Lluis, Mojica, Francisco J. M.

“…Non‐coding RNAs (crRNAs) produced from clustered regularly interspaced short palindromic repeats (CRISPR) loci and CRISPR‐associated (Cas) proteins of the…”
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On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals by Mojica, Francisco J.M, Montoliu, Lluis

“…Clustered regularly-interspaced short palindromic repeat (CRISPR) sequences cooperate with CRISPR-associated (Cas) proteins to form the basis of CRISPR-Cas…”
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Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria by Mojica, Francisco J. M., Díez‐Villaseñor, Cesar, Soria, Elena, Juez, Guadalupe

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An updated evolutionary classification of CRISPR–Cas systems by Makarova, Kira S., Wolf, Yuri I., Alkhnbashi, Omer S., Costa, Fabrizio, Shah, Shiraz A., Saunders, Sita J., Barrangou, Rodolphe, Brouns, Stan J. J., Charpentier, Emmanuelle, Haft, Daniel H., Horvath, Philippe, Moineau, Sylvain, Mojica, Francisco J. M., Terns, Rebecca M., Terns, Michael P., White, Malcolm F., Yakunin, Alexander F., Garrett, Roger A., van der Oost, John, Backofen, Rolf, Koonin, Eugene V.

“…Key Points CRISPR–Cas systems provide archaea and bacteria with adaptive immunity against viruses and plasmids. CRISPR–Cas genomic loci show extreme diversity…”
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Protospacer recognition motifs: Mixed identities and functional diversity by Shah, Shiraz A., Erdmann, Susanne, Mojica, Francisco J.M., Garrett, Roger A.

“…Protospacer adjacent motifs (PAMs) were originally characterized for CRISPR-Cas systems that were classified on the basis of their CRISPR repeat sequences. A…”
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CRISPR-Cas functional module exchange in Escherichia coli by Almendros, Cristóbal, Mojica, Francisco J M, Díez-Villaseñor, César, Guzmán, Noemí M, García-Martínez, Jesús

“…Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (cas) genes constitute the CRISPR-Cas systems found in the Bacteria…”
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The CRISPR conundrum: evolve and maybe die, or survive and risk stagnation by García-Martínez, Jesús, Maldonado, Rafael D, Guzmán, Noemí M, Mojica, Francisco J M

“…CRISPR-Cas represents a prokaryotic defense mechanism against invading genetic elements. Although there is a diversity of CRISPR-Cas systems, they all share…”
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Digging into the lesser-known aspects of CRISPR biology by Guzmán, Noemí M., Esquerra-Ruvira, Belén, Mojica, Francisco J. M.

“…A long time has passed since regularly interspaced DNA repeats were discovered in prokaryotes. Today, those enigmatic repetitive elements termed clustered…”
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