HIV and dementia: prevalence and risk factors

Objective: To determine the prevalence of patients at risk of developing HIV-associated neurocognitive disorder (HAND) and identify factors possibly associated with its occurence. Methods: Quantitative cross-sectional study conducted at the Specialized Care Service (Serviço de Atendimento Especializ...

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Published in:	Revista brasileira em promoção da saúde = Brazilian journal in health promotion Vol. 29; no. 2; pp. 212 - 218
Main Authors:	Gurgel Fernandes Távora, Lara, Martins Figueiredo, Thais, Moitas Krammer de Mesquita, Ramille, Ricarte Bezerra, Fernando, Pinheiro Aquino, Bruno, Keny de Baima Colares, Jeová
Format:	Journal Article
Language:	English
Published:	Fortaleza Universidade de Fortaleza - Centro de Ciências da Saúde 30-06-2016 Universidade de Fortaleza
Subjects:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome AIDS AIDS Dementia Complex Colleges & universities Dementia Diagnosis Epidemiology HIV Human immunodeficiency virus Identification methods Neurocognitive Disorders Patients Regression analysis Risk analysis Risk factors
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Summary:	Objective: To determine the prevalence of patients at risk of developing HIV-associated neurocognitive disorder (HAND) and identify factors possibly associated with its occurence. Methods: Quantitative cross-sectional study conducted at the Specialized Care Service (Serviço de Atendimento Especializado - SAE) for HIV/Aids of the Integrated Medical Care Center (Núcleo de Atendimento Médico Integrado - NAMI) of the University of Fortaleza (Universidade de Fortaleza - UNIFOR), Fortaleza, Ceará, Brazil. We reviewed medical records of all 249 patients that started medical follow-up at SAE/NAMI since its foundation (August/2010) until January/2014, including in the analysis those who completed the international HIV dementia scale - IHDS during routine medical visits. Epidemiological, clinical and laboratory variables were collected in addition to IHDS score and the sample was classified in two groups: patients with IHDS≥10 (Group 1) and IHDS<10 (Group 2). Chisquared test was used for categorical variables and student t test, mann whitney test and linear regression were used for numerical variables. Results: The study population consisted of 178 patients with mean IHDS score of 9.5 (+/- 1.6). HAND prevalence was 41.6% (74/178) (IHDS<10). These patients presented older mean age (37.4 years) and longer mean time from HIV diagnosis to medical follow-up than the others (10.1 months) when compared to Group 2 (31 years old and 4.6 months, respectively), suggesting that these two variables were possibly associated with HAND occurrence. Conclusion: The IHDS application showed a high prevalence of HAND in the study population. More advanced age and longer time from HIV diagnosis to medical follow-up are possibly associated with its occurence.
ISSN:	1806-1222 1806-1230
DOI:	10.5020/18061230.2016.p212