Search Results - "Moita, Luís F"

Venoarterial extracorporeal membrane oxygenation is routinely used in the intensive care unit, but are patients ready for it? by Velho, Tiago R., Pereira, Rafael M., Moita, Luís F.

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Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis by Almeida, Luís, Dhillon-LaBrooy, Ayesha, Castro, Carla N., Adossa, Nigatu, Carriche, Guilhermina M., Guderian, Melanie, Lippens, Saskia, Dennerlein, Sven, Hesse, Christina, Lambrecht, Bart N., Berod, Luciana, Schauser, Leif, Blazar, Bruce R., Kalesse, Markus, Müller, Rolf, Moita, Luís F., Sparwasser, Tim

“…While antibiotics are intended to specifically target bacteria, most are known to affect host cell physiology. In addition, some antibiotic classes are…”
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A new possibility: gene-expression-based diagnostics for presymptomatic diagnosis of hospital-acquired infections by Moita, Luís F., Sweeney, Timothy E., Póvoa, Pedro

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Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection by Colaço, Henrique G., Barros, André, Neves-Costa, Ana, Seixas, Elsa, Pedroso, Dora, Velho, Tiago, Willmann, Katharina L., Faisca, Pedro, Grabmann, Gerlinde, Yi, Hyon-Seung, Shong, Minho, Benes, Vladimir, Weis, Sebastian, Köcher, Thomas, Moita, Luís F.

“…Several classes of antibiotics have long been known to have beneficial effects that cannot be explained strictly on the basis of their capacity to control the…”
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CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis by Santos, Isa, Colaço, Henrique G., Neves-Costa, Ana, Seixas, Elsa, Velho, Tiago R., Pedroso, Dora, Barros, André, Martins, Rui, Carvalho, Nuno, Payen, Didier, Weis, Sebastian, Yi, Hyon-Seun, Shong, Minho, Moita, Luís F.

“…Sepsis is a life-threatening organ dysfunction condition caused by a dysregulated host response to an infection. Here we report that the circulating levels of…”
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MCL1 alternative polyadenylation is essential for cell survival and mitochondria morphology by Pereira-Castro, Isabel, Garcia, Beatriz C., Curinha, Ana, Neves-Costa, Ana, Conde-Sousa, Eduardo, Moita, Luís F., Moreira, Alexandra

“…Alternative polyadenylation in the 3′ UTR (3′ UTR-APA) is a mode of gene expression regulation, fundamental for mRNA stability, translation and localization…”
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CLOCK gene circannual expression in cluster headache by Oliveira, Renato, Neves-Costa, Ana, Pedroso, Dora, Paixão, Tiago, Barros, André B, Moita, Luís F, Gil-Gouveia, Raquel

“…Cluster headache is a primary headache disorder characterized by bouts with circadian and circannual patterns. The gene has a central role in regulating…”
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Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15 by Cimino, Irene, Kim, Hanna, Tung, Y. C. Loraine, Pedersen, Kent, Rimmington, Debra, Tadross, John A., Kohnke, Sara N., Neves-Costa, Ana, Barros, André, Joaquim, Stephanie, Bennett, Don, Melvin, Audrey, Lockhart, Samuel M., Rostron, Anthony J., Scott, Jonathan, Liu, Hui, Burling, Keith, Barker, Peter, Clatworthy, Menna R., Lee, E-Chiang, Simpson, A. John, Yeo, Giles S. H., Moita, Luís F., Bence, Kendra K., Jørgensen, Sebastian Beck, Coll, Anthony P., Breen, Danna M., O’Rahilly, Stephen

“…An acute increase in the circulating concentration of glucocorticoid hormones is essential for the survival of severe somatic stresses. Circulating…”
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A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis by Costa, Paulo M., Ferreira Moita, Luis, Pedroso, Dora, Neves-Costa, Ana, Moita, Catarina, Coelho, Hélder O., Barros, André, Carvalho, Nuno, Borges, Filipe C.

“…Acute appendicitis is the most frequent surgical abdominal emergency, but its etiology remains poorly understood. Histological examination of the appendix,…”
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Immunomodulatory Effects and Protection in Sepsis by the Antibiotic Moxifloxacin by Velho, Tiago R, Raquel, Helena, Figueiredo, Nuno, Neves-Costa, Ana, Pedroso, Dora, Santos, Isa, Willmann, Katharina, Moita, Luís F

“…Sepsis is a leading cause of death in Intensive Care Units. Despite its prevalence, sepsis remains insufficiently understood, with no substantial qualitative…”
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Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis by Amin, Abdulbasit, Badenes, Marina, Tüshaus, Johanna, de Carvalho, Érika, Burbridge, Emma, Faísca, Pedro, Trávníčková, Květa, Barros, André, Carobbio, Stefania, Domingos, Pedro M., Vidal-Puig, Antonio, Moita, Luís F., Maguire, Sarah, Stříšovský, Kvido, Ortega, Francisco J., Fernández-Real, José Manuel, Lichtenthaler, Stefan F., Adrain, Colin

“…The metalloprotease ADAM17 (also called TACE) plays fundamental roles in homeostasis by shedding key signaling molecules from the cell surface. Although its…”
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Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis by Badenes, Marina, Amin, Abdulbasit, González-García, Ismael, Félix, Inês, Burbridge, Emma, Cavadas, Miguel, Ortega, Francisco José, de Carvalho, Érika, Faísca, Pedro, Carobbio, Stefania, Seixas, Elsa, Pedroso, Dora, Neves-Costa, Ana, Moita, Luís F., Fernández-Real, José Manuel, Vidal-Puig, António, Domingos, Ana, López, Miguel, Adrain, Colin

“…Obesity is the result of positive energy balance. It can be caused by excessive energy consumption but also by decreased energy dissipation, which occurs under…”
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Tumor-Infiltrating T Cells in Skin Basal Cell Carcinomas and Squamous Cell Carcinomas: Global Th1 Preponderance with Th17 Enrichment-A Cross-Sectional Study by Cunha, Daniela, Neves, Marco, Silva, Daniela, Silvestre, Ana Rita, Nunes, Paula Borralho, Arrobas, Fernando, Ribot, Julie C, Ferreira, Fernando, Moita, Luís F, Soares-de-Almeida, Luís, Silva, João Maia, Filipe, Paulo, Ferreira, João

“…Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted…”
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Role of CD3+γδ-T cells in the association of obstructive sleep-disordered breathing and cancer by Staats, Richard, Rodrigues, Raquel, Barros, André, Bacelar-Nicolau, Leonor, Aguiar, Margarida, Fernandes, Dina, Moreira, Susana, Simões, André, Silva-Santos, Bruno, Rodrigues, João Valença, Barbara, Cristina, de Almeida, António Bugalho, Ferreira Moita, Luís F.

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In Vivo Identification of Novel Regulators and Conserved Pathways of Phagocytosis in A. gambiae by Moita, Luís F., Wang-Sattler, Rui, Michel, Kristin, Zimmermann, Timo, Blandin, Stephanie, Levashina, Elena A., Kafatos, Fotis C.

“…Anopheles gambiae uses effective immune responses, including phagocytosis, to fight microbial infection. We have developed a semiquantitative phagocytosis test…”
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Disease tolerance and immunity in host protection against infection by Soares, Miguel P., Teixeira, Luis, Moita, Luis F.

“…Key Points Disease tolerance is an evolutionarily conserved defence strategy against infection that does not exert a direct negative effect on the host…”
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Ketogenesis favors oxidative phosphorylation to promote disease tolerance by Jesus, Kátia, Moita, Luís F.

“…Pseudomonas aeruginosa is an opportunistic pathogen of great medical relevance, although the mechanisms involved in chronic P. aeruginosa infection are…”
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Tetracyclines: four rings to rule infections through resistance and disease tolerance by Jesus, Kátia, Moita, Luís F

“…Several classes of antibiotics have long been known for protective properties that cannot be explained through their direct antimicrobial effects. However, the…”
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Sec22b Regulates Phagosomal Maturation and Antigen Crosspresentation by Dendritic Cells by Cebrian, Ignacio, Visentin, Geraldine, Blanchard, Nicolas, Jouve, Mabel, Bobard, Alexandre, Moita, Catarina, Enninga, Jost, Moita, Luis F., Amigorena, Sebastian, Savina, Ariel

“…Antigen (Ag) crosspresentation by dendritic cells (DCs) involves the presentation of internalized Ags on MHC class I molecules to initiate CD8+ T cell-mediated…”
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Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles by Colombo, Marina, Moita, Catarina, van Niel, Guillaume, Kowal, Joanna, Vigneron, James, Benaroch, Philippe, Manel, Nicolas, Moita, Luis F, Théry, Clotilde, Raposo, Graça

“…Exosomes are extracellular vesicles (EVs) secreted upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane. The mechanisms involved in…”
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