Search Results - "Moira K. B. Whyte"

The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages by Daigneault, Marc, Preston, Julie A, Marriott, Helen M, Whyte, Moira K B, Dockrell, David H

“…Differentiated macrophages are the resident tissue phagocytes and sentinel cells of the innate immune response. The phenotype of mature tissue macrophages…”
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Zebrafish as a model for the study of neutrophil biology by Henry, Katherine M., Loynes, Catherine A., Whyte, Moira K. B., Renshaw, Stephen A.

“…Review of Zebrafish as a tool complementing existing approaches for the study of neutrophil biology, along with the advantages and advances driven by this…”
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Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis by Allen, Richard J, Guillen-Guio, Beatriz, Oldham, Justin M, Ma, Shwu-Fan, Dressen, Amy, Paynton, Megan L, Kraven, Luke M, Obeidat, Ma'en, Li, Xuan, Ng, Michael, Braybrooke, Rebecca, Molina-Molina, Maria, Hobbs, Brian D, Putman, Rachel K, Sakornsakolpat, Phuwanat, Booth, Helen L, Fahy, William A, Hart, Simon P, Hill, Mike R, Hirani, Nik, Hubbard, Richard B, McAnulty, Robin J, Millar, Ann B, Navaratnam, Vidyia, Oballa, Eunice, Parfrey, Helen, Saini, Gauri, Whyte, Moira K B, Zhang, Yingze, Kaminski, Naftali, Adegunsoye, Ayodeji, Strek, Mary E, Neighbors, Margaret, Sheng, Xuting R, Gudmundsson, Gunnar, Gudnason, Vilmundur, Hatabu, Hiroto, Lederer, David J, Manichaikul, Ani, Newell, Jr, John D, O'Connor, George T, Ortega, Victor E, Xu, Hanfei, Fingerlin, Tasha E, Bossé, Yohan, Hao, Ke, Joubert, Philippe, Nickle, David C, Sin, Don D, Timens, Wim, Furniss, Dominic, Morris, Andrew P, Zondervan, Krina T, Hall, Ian P, Sayers, Ian, Tobin, Martin D, Maher, Toby M, Cho, Michael H, Hunninghake, Gary M, Schwartz, David A, Yaspan, Brian L, Molyneaux, Philip L, Flores, Carlos, Noth, Imre, Jenkins, R Gisli, Wain, Louise V

“…Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to…”
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Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation by Mirchandani, Ananda S., Jenkins, Stephen J., Bain, Calum C., Sanchez-Garcia, Manuel A., Lawson, Hannah, Coelho, Patricia, Murphy, Fiona, Griffith, David M., Zhang, Ailiang, Morrison, Tyler, Ly, Tony, Arienti, Simone, Sadiku, Pranvera, Watts, Emily R., Dickinson, Rebecca. S., Reyes, Leila, Cooper, George, Clark, Sarah, Lewis, David, Kelly, Van, Spanos, Christos, Musgrave, Kathryn M., Delaney, Liam, Harper, Isla, Scott, Jonathan, Parkinson, Nicholas J., Rostron, Anthony J., Baillie, J. Kenneth, Clohisey, Sara, Pridans, Clare, Campana, Lara, Lewis, Philip Starkey, Simpson, A. John, Dockrell, David H., Schwarze, Jürgen, Hirani, Nikhil, Ratcliffe, Peter J., Pugh, Christopher W., Kranc, Kamil, Forbes, Stuart J., Whyte, Moira K. B., Walmsley, Sarah R.

“…Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the…”
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TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation by McGrath, Emmet E., Marriott, Helen M., Lawrie, Allan, Francis, Sheila E., Sabroe, Ian, Renshaw, Stephen A., Dockrell, David H., Whyte, Moira K. B.

“…The death ligand TRAIL plays a role in physiologic resolution of inflammation and exogenous TRAIL has potential therapeutic benefits in neutrophil‐dominant…”
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Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD by Bewley, Martin A, Belchamber, Kylie B R, Chana, Kirandeep K, Budd, Richard C, Donaldson, Gavin, Wedzicha, Jadwiga A, Brightling, Christopher E, Kilty, Iain, Donnelly, Louise E, Barnes, Peter J, Singh, Dave, Whyte, Moira K B, Dockrell, David H

“…Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage…”
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Regulation of neutrophil senescence by microRNAs by Ward, Jon R, Heath, Paul R, Catto, James W, Whyte, Moira K B, Milo, Marta, Renshaw, Stephen A

“…Neutrophils are rapidly recruited to sites of tissue injury or infection, where they protect against invading pathogens. Neutrophil functions are limited by a…”
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Interleukin-1β Regulates CXCL8 Release and Influences Disease Outcome in Response to Streptococcus pneumoniae, Defining Intercellular Cooperation between Pulmonary Epithelial Cells and Macrophages by MARRIOTT, Helen M, GASCOYNE, Kate A, DOCKRELL, David H, GOWDA, Ravi, GEARY, Ian, NICKLIN, Martin J. H, LANNELLI, Francesco, POZZI, Gianni, MITCHELL, Timothy J, WHYTE, Moira K. B, SABROE, Ian

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation by Wardle, David J, Burgon, Joseph, Sabroe, Ian, Bingle, Colin D, Whyte, Moira K B, Renshaw, Stephen A

“…Human tissue inflammation is terminated, at least in part, by the death of inflammatory neutrophils by apoptosis. The regulation of this process is therefore…”
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Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils by McGovern, Naomi N, Cowburn, Andrew S, Porter, Linsey, Walmsley, Sarah R, Summers, Charlotte, Thompson, Alfred A R, Anwar, Sadia, Willcocks, Lisa C, Whyte, Moira K B, Condliffe, Alison M, Chilvers, Edwin R

“…Neutrophils play a central role in the innate immune response and a critical role in bacterial killing. Most studies of neutrophil function have been conducted…”
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The Role of Toll-Like Receptors in the Regulation of Neutrophil Migration, Activation, and Apoptosis by Sabroe, Ian, Dower, Steven K., Whyte, Moira K. B.

“…Toll-like receptors (TLRs) playan essential role inthe detection of invading pathogens and in theinduction of host antimicrobial defenses. TLR4, the major…”
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Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis by Kiss, Judit, Mollenhauer, Martin, Walmsley, Sarah R, Kirchberg, Johanna, Radhakrishnan, Praveen, Niemietz, Thomas, Dudda, Johanna, Steinert, Gunnar, Whyte, Moira K B, Carmeliet, Peter, Mazzone, Massimiliano, Weitz, Jürgen, Schneider, Martin

“…Hypoxia and HIFs (HIF-1α and HIF-2α) modulate innate immune responses in the setting of systemic inflammatory responses and sepsis. The HIF prolyl hydroxylase…”
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A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci by Bewley, Martin A, Marriott, Helen M, Tulone, Calogero, Francis, Sheila E, Mitchell, Timothy J, Read, Robert C, Chain, Benny, Kroemer, Guido, Whyte, Moira K B, Dockrell, David H

“…The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1…”
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Toll-Like Receptor (TLR)2 and TLR4 in Human Peripheral Blood Granulocytes: A Critical Role for Monocytes in Leukocyte Lipopolysaccharide Responses by Sabroe, Ian, Jones, Elizabeth C, Usher, Lynne R, Whyte, Moira K. B, Dower, Steven K

“…Leukocyte responsiveness to LPS is dependent upon CD14 and receptors of the Toll-like receptor (TLR) family. Neutrophils respond to LPS, but conflicting data…”
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Pyocyanin Production by Pseudomonas aeruginosa Induces Neutrophil Apoptosis and Impairs Neutrophil-Mediated Host Defenses In Vivo by Allen, Lucy, Dockrell, David H, Pattery, Theresa, Lee, Daniel G, Cornelis, Pierre, Hellewell, Paul G, Whyte, Moira K. B

“…Clearance of neutrophils from inflamed sites is critical for resolution of inflammation, but pathogen-driven neutrophil apoptosis can impair host defenses. We…”
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The expression and roles of Toll-like receptors in the biology of the human neutrophil by Parker, Lisa C., Whyte, Moira K. B., Dower, Steven K., Sabroe, Ian

“…Neutrophils are amongst the first immune cells to arrive at sites of infection, where they initiate antimicrobial and proinflammatory functions, which serve to…”
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Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span by Sabroe, Ian, Prince, Lynne R, Jones, Elizabeth C, Horsburgh, Malcolm J, Foster, Simon J, Vogel, Stefanie N, Dower, Steven K, Whyte, Moira K. B

“…Neutrophil responses to commercial LPS, a dual Toll-like receptor (TLR)2 and TLR4 activator, are regulated by TLR expression, but are amplified by…”
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Subversion of a Lysosomal Pathway Regulating Neutrophil Apoptosis by a Major Bacterial Toxin, Pyocyanin by Prince, Lynne R, Bianchi, Stephen M, Vaughan, Kathryn M, Bewley, Martin A, Marriott, Helen M, Walmsley, Sarah R, Taylor, Graham W, Buttle, David J, Sabroe, Ian, Dockrell, David H, Whyte, Moira K. B

“…Neutrophils undergo rapid constitutive apoptosis that is accelerated following bacterial ingestion as part of effective immunity, but is also accelerated by…”
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Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection by Dockrell, David H, Marriott, Helen M, Prince, Lynne R, Ridger, Victoria C, Ince, Paul G, Hellewell, Paul G, Whyte, Moira K. B

“…The role of alveolar macrophages (AM) in host defense against pulmonary infection has been difficult to establish using in vivo models. This may reflect a…”
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Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor by Ward, Jon R, Bingle, Lynne, Judge, Heather M, Brown, Simon B, Storey, Robert F, Whyte, Moira K B, Dower, Steven K, Buttle, David J, Sabroe, Ian

“…Inappropriate platelet activation is a feature of acute and chronic diseases such as disseminated intravascular coagulation (DIC) and atherosclerosis. Since…”
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