Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring

One of the most consumed pesticides in the world is glyphosate, the active ingredient in the herbicide ROUNDUP®. Studies demonstrate that glyphosate can act as an endocrine disruptor and that exposure to this substance at critical periods in the developmental period may program the fetus to induce r...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of developmental origins of health and disease Vol. 11; no. 2; p. 146
Main Authors:	Teleken, Jakeline Liara, Gomes, Ellen Carolina Zawoski, Marmentini, Carine, Moi, Milara Bruna, Ribeiro, Rosane Aparecida, Balbo, Sandra Lucinei, Amorim, Elaine Manoela Porto, Bonfleur, Maria Lúcia
Format:	Journal Article
Language:	English
Published:	England 01-04-2020
Subjects:	Animals Animals, Suckling Disease Models, Animal Female Gestational Weight Gain - drug effects Glycine - analogs & derivatives Glycine - toxicity Glyphosate Herbicides - toxicity Humans Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Lactation Luteinizing Hormone - blood Luteinizing Hormone - metabolism Male Maternal Exposure - adverse effects Mice Pregnancy Prenatal Exposure Delayed Effects - blood Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - pathology Seminiferous Epithelium - drug effects Seminiferous Epithelium - pathology Sperm Count Spermatogenesis - drug effects Spermatozoa - drug effects Spermatozoa - growth & development Testosterone - analysis Testosterone - metabolism hypothalamus–pituitary–testicular axis spermatozoa testosterone pesticides Developmental origins of health and disease endocrine disruptor chemical
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	One of the most consumed pesticides in the world is glyphosate, the active ingredient in the herbicide ROUNDUP®. Studies demonstrate that glyphosate can act as an endocrine disruptor and that exposure to this substance at critical periods in the developmental period may program the fetus to induce reproductive damage in adulthood. Our hypothesis is that maternal exposure to glyphosate during pregnancy and lactation in mice will affect the development of male reproductive organs, impairing male fertility during adult life. Female mice consumed 0.5% glyphosate-ROUNDUP® in their drinking water [glyphosate-based herbicide (GBH) group] or filtered water [control (CTRL) group] from the fourth day of pregnancy until the end of the lactation period. Male F1 offspring were designated, according to their mother's treatment, as CTRL-F1 and GBH-F1. Female mice that drank glyphosate displayed reduced body weight (BW) gain during gestation, but no alterations in litter size. Although GBH male F1 offspring did not exhibit modifications in BW, they demonstrated delayed testicular descent. Furthermore, at PND150, GBH-F1 mice presented a lower number of spermatozoa in the cauda epididymis and reduced epithelial height of the seminiferous epithelium. Notably, intratesticular testosterone concentrations were enhanced in GBH-F1 mice; we show that it is an effect associated with increased plasma and pituitary concentrations of luteinizing hormone. Therefore, data indicate that maternal exposure to glyphosate-ROUNDUP® during pregnancy and lactation may lead to decreased spermatogenesis and disruptions in hypothalamus-pituitary-testicular axis regulation in F1 offspring.
ISSN:	2040-1752
DOI:	10.1017/S2040174419000382