Search Results - "Mohtar, M"

CD44: A Multifunctional Mediator of Cancer Progression by Hassn Mesrati, Malak, Syafruddin, Saiful Effendi, Mohtar, M Aiman, Syahir, Amir

“…CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells…”
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WIDENING THE BOTTLENECK OF PHOSPHOPROTEOMICS: EVOLVING STRATEGIES FOR PHOSPHOPEPTIDE ENRICHMENT by Low, Teck Yew, Mohtar, M. Aiman, Lee, Pey Yee, Omar, Nursyazwani, Zhou, Houjiang, Ye, Mingliang

“…Phosphorylation is a form of protein posttranslational modification (PTM) that regulates many biological processes. Whereas phosphoproteomics is a scientific…”
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Revisiting the Roles of Pro-Metastatic EpCAM in Cancer by Mohtar, M Aiman, Syafruddin, Saiful Effendi, Nasir, Siti Nurmi, Low, Teck Yew

“…Epithelial cell adhesion molecule (EpCAM) is a cell surface protein that was discovered as a tumour marker of epithelial origins nearly four decades ago. EpCAM…”
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Connecting Proteomics to Next‐Generation Sequencing: Proteogenomics and Its Current Applications in Biology by Low, Teck Yew, Mohtar, M. Aiman, Ang, Mia Yang, Jamal, Rahman

“…Understanding the relationship between genotypes and phenotypes is essential to disentangle biological mechanisms and to unravel the molecular basis of…”
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Recent progress in mass spectrometry-based strategies for elucidating protein–protein interactions by Low, Teck Yew, Syafruddin, Saiful Effendi, Mohtar, M. Aiman, Vellaichamy, Adaikkalam, A Rahman, Nisa Syakila, Pung, Yuh-Fen, Tan, Chris Soon Heng

“…Protein–protein interactions are fundamental to various aspects of cell biology with many protein complexes participating in numerous fundamental biological…”
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The anterior gradient-2 interactome by Delom, Frederic, Mohtar, M Aiman, Hupp, Ted, Fessart, Delphine

“…The anterior gradient-2 (AGR2) is an endoplasmic reticulum (ER)-resident protein belonging to the protein disulfide isomerase family that mediates the…”
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Two Sides of the Same Coin: The Roles of KLF6 in Physiology and Pathophysiology by Syafruddin, Saiful E, Mohtar, M Aiman, Wan Mohamad Nazarie, Wan Fahmi, Low, Teck Yew

“…The Krüppel-like factors (KLFs) family of proteins control several key biological processes that include proliferation, differentiation, metabolism, apoptosis…”
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Impact of the Cancer Cell Secretome in Driving Breast Cancer Progression by Zahari, Syazalina, Syafruddin, Saiful Effendi, Mohtar, M Aiman

“…Breast cancer is a complex and heterogeneous disease resulting from the accumulation of genetic and epigenetic alterations in breast epithelial cells. Despite…”
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Integration of RNA-Seq and proteomics data identifies glioblastoma multiforme surfaceome signature by Syafruddin, Saiful Effendi, Nazarie, Wan Fahmi Wan Mohamad, Moidu, Nurshahirah Ashikin, Soon, Bee Hong, Mohtar, M. Aiman

“…Background Glioblastoma multiforme (GBM) is a highly lethal, stage IV brain tumour with a prevalence of approximately 2 per 10,000 people globally. The cell…”
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More Than Meets the Eye: Revisiting the Roles of Heat Shock Factor 4 in Health and Diseases by Syafruddin, Saiful Effendi, Ling, Sheen, Low, Teck Yew, Mohtar, M Aiman

“…Cells encounter a myriad of endogenous and exogenous stresses that could perturb cellular physiological processes. Therefore, cells are equipped with several…”
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Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures by Leong, Alyssa Zi-Xin, Lee, Pey Yee, Mohtar, M Aiman, Syafruddin, Saiful Effendi, Pung, Yuh-Fen, Low, Teck Yew

“…A short open reading frame (sORFs) constitutes ≤ 300 bases, encoding a microprotein or sORF-encoded protein (SEP) which comprises ≤ 100 amino acids…”
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Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma by Abuhamad, Asmaa Y, Mohamad Zamberi, Nurul Nadia, Vanharanta, Sakari, Mohd Yusuf, Siti Nur Hasanah, Mohtar, M Aiman, Syafruddin, Saiful Effendi

“…Clear cell renal cell carcinoma (ccRCC) is a hypervascular tumor that is characterized by bi-allelic inactivation of the tumor suppressor gene and mTOR…”
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Reflux of Endoplasmic Reticulum proteins to the cytosol inactivates tumor suppressors by Sicari, Daria, Centonze, Federica G, Pineau, Raphael, Le Reste, Pierre-Jean, Negroni, Luc, Chat, Sophie, Mohtar, M Aiman, Thomas, Daniel, Gillet, Reynald, Hupp, Ted, Chevet, Eric, Igbaria, Aeid

“…In the past decades, many studies reported the presence of endoplasmic reticulum (ER)-resident proteins in the cytosol. However, the mechanisms by which these…”
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The Sequence-specific Peptide-binding Activity of the Protein Sulfide Isomerase AGR2 Directs Its Stable Binding to the Oncogenic Receptor EpCAM by Mohtar, M. Aiman, Hernychova, Lenka, O'Neill, J. Robert, Lawrence, Melanie L., Murray, Euan, Vojtesek, Borek, Hupp, Ted R.

“…AGR2 is an oncogenic endoplasmic reticulum (ER)-resident protein disulfide isomerase. AGR2 protein has a relatively unique property for a chaperone in that it…”
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Impact of Chemotherapy on Extracellular Vesicles: Understanding the Chemo-EVs by Ab Razak, Nur' Syahada, Ab Mutalib, Nurul Syakima, Mohtar, M Aiman, Abu, Nadiah

“…Chemotherapy is the standard go-to treatment for cancer besides surgery and radiation. It has recently come to light that the interaction between chemotherapy…”
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Functions and mechanisms of protein disulfide isomerase family in cancer emergence by Rahman, Nisa Syakila A, Zahari, Syazalina, Syafruddin, Saiful Effendi, Firdaus-Raih, Mohd, Low, Teck Yew, Mohtar, M. Aiman

“…The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the…”
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Cholesterol accumulation in ccRCC: the role of ccRCC-initiating VHL-HIFα pathway by Mohtar, M. Aiman, Hasanah Mohd Yusuf, Siti Nur, Syafruddin, Saiful Effendi

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Secretion of pro-oncogenic AGR2 protein in cancer by Moidu, Nurshahirah Ashikin, A Rahman, Nisa Syakila, Syafruddin, Saiful Effendi, Low, Teck Yew, Mohtar, M. Aiman

“…Anterior gradient-2 (AGR2) protein mediates the formation, breakage and isomerization of disulphide bonds during protein maturation in the endoplasmic…”
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An Ultrasensitive Biosensor for Detection of Femtogram Levels of the Cancer Antigen AGR2 Using Monoclonal Antibody Modified Screen-Printed Gold Electrodes by Białobrzeska, Wioleta, Dziąbowska, Karolina, Lisowska, Małgorzata, Mohtar, M Aiman, Muller, Petr, Vojtesek, Borivoj, Krejcir, Radovan, O'Neill, Robert, Hupp, Ted R, Malinowska, Natalia, Bięga, Ewelina, Bigus, Daniel, Cebula, Zofia, Pala, Katarzyna, Czaczyk, Elżbieta, Żołędowska, Sabina, Nidzworski, Dawid

“…The detection of cancer antigens is a major aim of cancer research in order to develop better patient management through early disease detection. Many cancers…”
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dCas9 Tells Tales: Probing Gene Function and Transcription Regulation in Cancer by Mohamad Zamberi, Nurul Nadia, Abuhamad, Asmaa Y, Low, Teck Yew, Mohtar, M Aiman, Syafruddin, Saiful Effendi

“…Clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing is evolving into an essential tool in the field of biological and…”
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