Search Results - "Mohr, Michael K F"

Doping In Vivo Alkylation in E. coli by Introducing the Direct Sulfurylation Pathway of S. cerevisiae by Mohr, Michael K F, Benčić, Patricia, Andexer, Jennifer N

“…Methylation and alkylation are important techniques used for the synthesis and derivatisation of small molecules and natural products. Application of…”
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Enzymatic Synthesis of l‐Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade by Mohr, Michael K. F., Saleem‐Batcha, Raspudin, Cornelissen, Nicolas V., Andexer, Jennifer N.

“…Chemical modification of small molecules is a key step for the development of pharmaceuticals. S‐adenosyl‐l‐methionine (SAM) analogues are used by…”
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Biomimetic S‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes by Gericke, Lukas, Mhaindarkar, Dipali, Karst, Lukas C., Jahn, Sören, Kuge, Marco, Mohr, Michael K. F., Gagsteiger, Jana, Cornelissen, Nicolas V., Wen, Xiaojin, Mordhorst, Silja, Jessen, Henning J., Rentmeister, Andrea, Seebeck, Florian P., Layer, Gunhild, Loenarz, Christoph, Andexer, Jennifer N.

“…S‐Adenosylmethionine (SAM) is an enzyme cofactor involved in methylation, aminopropyl transfer, and radical reactions. This versatility renders SAM‐dependent…”
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Substrate Induced Movement of the Metal Cofactor between Active and Resting State by Marsden, Stefan R., Wijma, Hein J., Mohr, Michael K. F., Justo, Inês, Hagedoorn, Peter‐Leon, Laustsen, Jesper, Jeffries, Cy M., Svergun, Dmitri, Mestrom, Luuk, McMillan, Duncan G. G., Bento, Isabel, Hanefeld, Ulf

“…Regulation of enzyme activity is vital for living organisms. In metalloenzymes, far‐reaching rearrangements of the protein scaffold are generally required to…”
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Several Polyphosphate Kinase 2 Enzymes Catalyse the Production of Adenosine 5′‐Polyphosphates by Mordhorst, Silja, Singh, Jyoti, Mohr, Michael K. F., Hinkelmann, Rahel, Keppler, Michael, Jessen, Henning J., Andexer, Jennifer N.

“…Polyphosphate kinases (PPKs) are involved in many metabolic processes; enzymes of the second family (PPK2) are responsible for nucleotide synthesis fuelled by…”
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The archaeal triphosphate tunnel metalloenzyme SaTTM defines structural determinants for the diverse activities in the CYTH protein family by Vogt, Marian S., Ngouoko Nguepbeu, Roi R., Mohr, Michael K.F., Albers, Sonja-Verena, Essen, Lars-Oliver, Banerjee, Ankan

“…CYTH proteins make up a large superfamily that is conserved in all three domains of life. These enzymes have a triphosphate tunnel metalloenzyme (TTM) fold,…”
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Expanding the Substrate Scope of N‐ and O‐Methyltransferases from Plants for Chemoselective Alkylation by Jockmann, Emely, Subrizi, Fabiana, Mohr, Michael K. F., Carter, Eve M., Hebecker, Pia M., Popadić, Désirée, Hailes, Helen C., Andexer, Jennifer N.

“…Methylation reactions are of significant interest when generating pharmaceutically active molecules and building blocks for other applications. Synthetic…”
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Substrate Induced Movement of the Metal Cofactor between Active and Resting State by Marsden, Stefan R., Wijma, Hein J., Mohr, Michael K. F., Justo, Inês, Hagedoorn, Peter‐Leon, Laustsen, Jesper, Jeffries, Cy M., Svergun, Dmitri, Mestrom, Luuk, McMillan, Duncan G. G., Bento, Isabel, Hanefeld, Ulf

“…Regulation of enzyme activity is vital for living organisms. In metalloenzymes, far‐reaching rearrangements of the protein scaffold are generally required to…”
Get full text

Doping In Vivo Alkylation in E. coli by Introducing the Direct Sulfurylation Pathway of S. cerevisiae by Mohr, Michael K. F., Benčić, Patricia, Andexer, Jennifer N.

“…Abstract Methylation and alkylation are important techniques used for the synthesis and derivatisation of small molecules and natural products. Application of…”
Get full text