Adherence of Human Immunodeficiency Virus—Infected Patients to Antiretroviral Therapy

Adherence of Human Immunodeficiency Virus—Infected Patients to Antiretroviral Therapy

The impact of demographic, psychosocial, and medical regimen-related variables on adherence of 123 human immunodeficiency virus (HIV)-infected patients to antiretroviral therapy was assessed by means of refill methodology. Satisfaction with social support (P = .029), problem-focused coping (P = .027...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases Vol. 29; no. 4; pp. 824 - 830
Main Authors: Singh, Nina, Berman, Stephen M., Swindells, Susan, Justis, Janice C., Mohr, Jeffrey A., Squier, Cheryl, Wagener, Marilyn M.
Format: Journal Article Conference Proceeding
Language:English
Published: Chicago, IL The University of Chicago Press 01-10-1999
University of Chicago Press
Subjects:
Adaptation, Psychological
Adult
Aged
AIDS
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretrovirals
Antiviral agents
Antivirals
Biological and medical sciences
CD4 Lymphocyte Count
Clinical Articles
Diseases
Emotional support
Female
HIV
HIV Infections - drug therapy
HIV Infections - ethnology
HIV Infections - psychology
Hope
Humans
Male
Medical sciences
Middle Aged
Motivation
Patient Compliance
Pharmacology. Drug treatments
Prospective Studies
Protease inhibitors
Quality of Life
Social Support
Human
Immunopathology
Demography
AIDS
Personality
Immune deficiency
Quality of life
Infection
Drug compliance
Chemotherapy
Treatment
Sociodemographic factor
Viral disease
Risk factor
Antiviral
Coping
Predictive factor
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The impact of demographic, psychosocial, and medical regimen-related variables on adherence of 123 human immunodeficiency virus (HIV)-infected patients to antiretroviral therapy was assessed by means of refill methodology. Satisfaction with social support (P = .029), problem-focused coping (P = .027), and active-behavioral coping (P = .011) correlated significantly with adherence, whereas loss of motivation (P = .006), hopelessness (P = .16), and avoidant coping (p = .015) correlated with nonadherence. At the 6-month follow-up, the mean CD4 cell count differed significantly among adherent versus nonadherent patients (a mean increase of 78/mm3 vs. a mean decrease of 5/mm3; P = .018). Adherence did not correlate with the number of antiretroviral medications consumed per day (mean, 3.0 vs. 2.5). Non-Caucasian patients were more likely to be nonadherent than Caucasian patients (relative risk, 2.5; 95% confidence interval, 1.2–5.3; P = .013); this difference was not explained by age, education, employment, income, history of intravenous drug use, or medical regimen. Non-Caucasian patients, however, were less satisfied with their social support (P = .04) and informational support (P = .016) and were more likely to utilize emotion-focused coping (P = .01). Thus, satisfaction with social support and coping style significantly impacted adherence and likely accounted for the observed racial difference in adherence among HIV-infected patients.
Bibliography:istex:780619A7F6D1F2EA6CC6BF3C20490823A8D2D5C6
ark:/67375/HXZ-7377DDB8-J
Reprints or correspondence: Dr. Nina Singh, Infectious Disease Section, Veterans Affairs Medical Center, University Drive C, Pittsburgh, Pennsylvania 15240.
ISSN:1058-4838
1537-6591
DOI:10.1086/520443