Search Results - "Mohler, Kyle"

Translational fidelity and mistranslation in the cellular response to stress by Mohler, Kyle, Ibba, Michael

“…Faithful translation of mRNA into the corresponding polypeptide is a complex multistep process, requiring accurate amino acid selection, transfer RNA (tRNA)…”
Get full text

System‐wide optimization of an orthogonal translation system with enhanced biological tolerance by Mohler, Kyle, Moen, Jack M, Rogulina, Svetlana, Rinehart, Jesse

“…Over the past two decades, synthetic biological systems have revolutionized the study of cellular physiology. The ability to site‐specifically incorporate…”
Get full text

Mistranslation of the genetic code by Moghal, Adil, Mohler, Kyle, Ibba, Michael

“…During mRNA decoding at the ribosome, deviations from stringent codon identity, or “mistranslation,” are generally deleterious and infrequent. Observations of…”
Get full text

Enhanced access to the human phosphoproteome with genetically encoded phosphothreonine by Moen, Jack M., Mohler, Kyle, Rogulina, Svetlana, Shi, Xiaojian, Shen, Hongying, Rinehart, Jesse

“…Protein phosphorylation is a ubiquitous post-translational modification used to regulate cellular processes and proteome architecture by modulating…”
Get full text

Hetero‐trans‐β‐glucanase, an enzyme unique to Equisetum plants, functionalizes cellulose by Simmons, Thomas J., Mohler, Kyle E., Holland, Claire, Goubet, Florence, Franková, Lenka, Houston, Douglas R., Hudson, Andrew D., Meulewaeter, Frank, Fry, Stephen C.

“…Summary Cell walls are metabolically active components of plant cells. They contain diverse enzymes, including transglycanases (endotransglycosylases), enzymes…”
Get full text

Hetero-trans-[beta]-glucanase, an enzyme unique to Equisetum plants, functionalizes cellulose by Simmons, Thomas J, Mohler, Kyle E, Holland, Claire, Goubet, Florence, Frankova, Lenka, Houston, Douglas R, Hudson, Andrew D, Meulewaeter, Frank, Fry, Stephen C

“…Summary Cell walls are metabolically active components of plant cells. They contain diverse enzymes, including transglycanases (endotransglycosylases), enzymes…”
Get full text

Deacylated tRNA Accumulation Is a Trigger for Bacterial Antibiotic Persistence Independent of the Stringent Response by Wood, Whitney N, Mohler, Kyle, Rinehart, Jesse, Ibba, Michael

“…Bacterial antibiotic persistence occurs when bacteria are treated with an antibiotic and the majority of the population rapidly dies off, but a small…”
Get full text

Alanyl-tRNA Synthetase Quality Control Prevents Global Dysregulation of the Escherichia coli Proteome by Kelly, Paul, Backes, Nicholas, Mohler, Kyle, Buser, Christopher, Kavoor, Arundhati, Rinehart, Jesse, Phillips, Gregory, Ibba, Michael

“…Mechanisms have evolved to prevent errors in replication, transcription, and translation of genetic material, with translational errors occurring most…”
Get full text

Mixed-linkage glucan:xyloglucan endotransglucosylase (MXE) re-models hemicelluloses in Equisetum shoots but not in barley shoots or Equisetum callus by Mohler, Kyle E., Simmons, Thomas J., Fry, Stephen C.

“…Among land-plant hemicelluloses, xyloglucan is ubiquitous, whereas mixed-linkage (1→3),(1→4)-β-d-glucan (MLG) is confined to the Poales (e.g. cereals) and…”
Get full text

Mixed-linkage β-glucan : xyloglucan endotransglucosylase, a novel wall-remodelling enzyme from Equisetum (horsetails) and charophytic algae by Fry, Stephen C, Mohler, Kyle E, Nesselrode, Bertram H.W.A, Franková, Lenka

“…Mixed-linkage (1[rightward arrow]3,1[rightward arrow]4)-β- d-glucan (MLG), a hemicellulose long thought to be confined to certain Poales, was recently also…”
Get full text

Novel Compound Heterozygous Mutations Expand the Recognized Phenotypes of FARS2-Linked Disease by Walker, Melissa A., Mohler, Kyle P., Hopkins, Kyle W., Oakley, Derek H., Sweetser, David A., Ibba, Michael, Frosch, Matthew P., Thibert, Ronald L.

“…Mutations in mitochondrial aminoacyl-tRNA synthetases are an increasingly recognized cause of human diseases, often arising in individuals with compound…”
Get full text

Elastocapillary effects determine early matrix deformation by glioblastoma cell spheroids by Ang, Ida, Yousafzai, Muhammad Sulaiman, Yadav, Vikrant, Mohler, Kyle, Rinehart, Jesse, Bouklas, Nikolaos, Murrell, Michael

“…During cancer pathogenesis, cell-generated mechanical stresses lead to dramatic alterations in the mechanical and organizational properties of the…”
Get full text

Isoacceptor specific characterization of tRNA aminoacylation and misacylation in vivo by Mohler, Kyle, Mann, Rebecca, Ibba, Michael

“…Amino acid misincorporation during protein synthesis occurs due to misacylation of tRNAs or defects in decoding at the ribosome. While misincorporation of…”
Get full text

SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces by Lee, Sung Hoon, Yousafzai, Muhammad Sulaiman, Mohler, Kyle, Yadav, Vikrant, Amiri, Sorosh, Szuszkiewicz, Joanna, Levchenko, Andre, Rinehart, Jesse, Murrell, Michael

“…The invasive potential of glioblastoma cells is attributed to large changes in pressure and volume, driven by diverse elements, including the cytoskeleton and…”
Get full text

Correction: The mechanism of β-N-methylamino-L-alanine inhibition of tRNA aminoacylation and its impact on misincorporation by Han, Nien-Ching, Bullwinkle, Tammy J., Loeb, Kaeli F., Faull, Kym F., Mohler, Kyle, Rinehart, Jesse, Ibba, Michael

Get full text

The mechanism of β- N -methylamino-l-alanine inhibition of tRNA aminoacylation and its impact on misincorporation by Han, Nien-Ching, Bullwinkle, Tammy J., Loeb, Kaeli F., Faull, Kym F., Mohler, Kyle, Rinehart, Jesse, Ibba, Michael

“…β- N -methylamino- l -alanine (BMAA) is a nonproteinogenic amino acid that has been associated with neurodegenerative diseases, including amyotrophic lateral…”
Get full text

MS-READ: Quantitative measurement of amino acid incorporation by Mohler, Kyle, Aerni, Hans-Rudolf, Gassaway, Brandon, Ling, Jiqiang, Ibba, Michael, Rinehart, Jesse

“…Ribosomal protein synthesis results in the genetically programmed incorporation of amino acids into a growing polypeptide chain. Faithful amino acid…”
Get full text

A multi-purpose, regenerable, proteome-scale, human phosphoserine resource for phosphoproteomics by Gassaway, Brandon M., Li, Jiaming, Rad, Ramin, Mintseris, Julian, Mohler, Kyle, Levy, Tyler, Aguiar, Mike, Beausoleil, Sean A., Paulo, Joao A., Rinehart, Jesse, Huttlin, Edward L., Gygi, Steven P.

“…Mass-spectrometry-based phosphoproteomics has become indispensable for understanding cellular signaling in complex biological systems. Despite the central role…”
Get full text

Aminoacyl-tRNA quality control is required for efficient activation of the TOR pathway regulator Gln3p by Mohler, Kyle, Mann, Rebecca, Kyle, Amanda, Reynolds, Noah, Ibba, Michael

“…The aminoacylation status of the cellular tRNA pool regulates both general amino acid control (GAAC) and target of rapamycin (TOR) stress response pathways in…”
Get full text

The mechanism of β-N-methylamino-l-alanine inhibition of tRNA aminoacylation and its impact on misincorporation by Han, Nien-Ching, Bullwinkle, Tammy J., Loeb, Kaeli F., Faull, Kym F., Mohler, Kyle, Rinehart, Jesse, Ibba, Michael

“…β-N-methylamino-l-alanine (BMAA) is a nonproteinogenic amino acid that has been associated with neurodegenerative diseases, including amyotrophic lateral…”
Get full text