Search Results - "Mohler, K.M"

The discovery of anthranilic acid-based mmp inhibitors. Part 3: incorporation of basic amines by Levin, J.I, Chen, J.M, Du, M.T, Nelson, F.C, Wehr, T, DiJoseph, J.F, Killar, L.M, Skala, S, Sung, A, Sharr, M.A, Roth, C.E, Jin, G, Cowling, R, Di, L, Sherman, M, Xu, Z.B, March, C.J, Mohler, K.M, Black, R.A, Skotnicki, J.S

“…Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine…”
Get full text

The discovery of anthranilic acid-based MMP inhibitors. Part 2 : SAR of the 5-position and P11 groups by LEVIN, J. I, CHEN, J, KILLAR, L. M, SKALA, S, SUNG, A, SHARR, M, ROTH, C, JIN, G, COWLING, R, MOHLER, K. M, BLACK, R. A, MARCH, C. J, DU, M, SKOTNICKI, J. S, HOGAN, M, KINCAID, S, NELSON, F. C, VENKATESAN, A. M, WEHR, T, ZASK, A, DIJOSEPH, J

Get full text

Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group by LEVIN, J. I, CHEN, J. M, MARCH, C. J, MOHLER, K. M, BLACK, R. A, SKOTNICKI, J. S, DU, M. T, NELSON, F. C, KILLAR, L. M, SKALA, S, SUNG, A, JIN, G, COWLING, R, BARONE, D

“…The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing novel acetylenic P1' groups was explored. In particular, compound 4t bearing a…”
Get full text

Immune Function in Patients with Rheumatoid Arthritis Treated with Etanercept by Moreland, L.W., Bucy, R.P., Weinblatt, M.E., Mohler, K.M., Spencer-Green, G.T., Chatham, W.W.

“…Etanercept, a recombinant human tumor necrosis factor (TNF) inhibitor that binds both soluble and cell-bound TNF, has been shown to reduce disease activity and…”
Get full text

Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates by Levin, J.I., Chen, J.M., Cheung, K., Cole, D., Crago, C., Santos, E.Delos, Du, X., Khafizova, G., MacEwan, G., Niu, C., Salaski, E.J., Zask, A., Cummons, T., Sung, A., Xu, J., Zhang, Y., Xu, W., Ayral-Kaloustian, S., Jin, G., Cowling, R., Barone, D., Mohler, K.M., Black, R.A., Skotnicki, J.S.

“…The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors, all bearing a butynyloxy P1′ group, was explored. In particular, compound 5j has…”
Get full text

Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors by Zask, A., Gu, Y., Albright, J.D., Du, X., Hogan, M., Levin, J.I., Chen, J.M., Killar, L.M., Sung, A., DiJoseph, J.F., Sharr, M.A., Roth, C.E., Skala, S., Jin, G., Cowling, R., Mohler, K.M., Barone, D., Black, R., March, C., Skotnicki, J.S.

“…Potent and selective bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors were synthesized by a novel convergent route. Selectivity and efficacy versus…”
Get full text

The discovery of anthranilic acid-Based MMP inhibitors. Part 2: SAR of the 5-position and P1 1 groups by Levin, J.I., Chen, J., Du, M., Hogan, M., Kincaid, S., Nelson, F.C., Venkatesan, A.M., Wehr, T., Zask, A., DiJoseph, J., Killar, L.M., Skala, S., Sung, A., Sharr, M., Roth, C., Jin, G., Cowling, R., Mohler, K.M., Black, R.A., March, C.J., Skotnicki, J.S.

“…A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and…”
Get full text