Search Results - "Mohler, K M"

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists by Mohler, KM, Torrance, DS, Smith, CA, Goodwin, RG, Stremler, KE, Fung, VP, Madani, H, Widmer, MB

“…Two forms (monomeric or dimeric) of the extracellular, ligand-binding portion of the human p80 cell-surface receptor for TNF were used to antagonize TNF…”
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Fully human CD19-specific chimeric antigen receptors for T-cell therapy by Sommermeyer, D, Hill, T, Shamah, S M, Salter, A I, Chen, Y, Mohler, K M, Riddell, S R

“…Impressive results have been achieved by adoptively transferring T-cells expressing CD19-specific CARs with binding domains from murine mAbs to treat B-cell…”
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Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group by LEVIN, J. I, CHEN, J. M, MARCH, C. J, MOHLER, K. M, BLACK, R. A, SKOTNICKI, J. S, DU, M. T, NELSON, F. C, KILLAR, L. M, SKALA, S, SUNG, A, JIN, G, COWLING, R, BARONE, D

“…The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing novel acetylenic P1' groups was explored. In particular, compound 4t bearing a…”
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Immune Function in Patients with Rheumatoid Arthritis Treated with Etanercept by Moreland, L.W., Bucy, R.P., Weinblatt, M.E., Mohler, K.M., Spencer-Green, G.T., Chatham, W.W.

“…Etanercept, a recombinant human tumor necrosis factor (TNF) inhibitor that binds both soluble and cell-bound TNF, has been shown to reduce disease activity and…”
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Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates by Levin, J.I., Chen, J.M., Cheung, K., Cole, D., Crago, C., Santos, E.Delos, Du, X., Khafizova, G., MacEwan, G., Niu, C., Salaski, E.J., Zask, A., Cummons, T., Sung, A., Xu, J., Zhang, Y., Xu, W., Ayral-Kaloustian, S., Jin, G., Cowling, R., Barone, D., Mohler, K.M., Black, R.A., Skotnicki, J.S.

“…The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors, all bearing a butynyloxy P1′ group, was explored. In particular, compound 5j has…”
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Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery by Kennedy, MK, Torrance, DS, Picha, KS, Mohler, KM

“…Experimental autoimmune encephalomyelitis (EAE) serves as an important animal model for understanding the events that lead to immune-mediated inflammation and…”
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Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing by Mohler, Kendall M, Sleath, Paul R, Fitzner, Jeffrey N, Cerretti, Douglas Pat, Alderson, Mark, Kerwar, Suresh S, Torranee, Dauphine S, Otten-Evans, Carol, Greenstreet, Teresa, Weerawarna, Kumudini, Kronheim, Shirley R, Petersen, Melissa, Gerhart, Mary, Kozlosky, Carl J, March, Carl J, Black, Roy A

“…Tumour necrosis factor (tumour necrosis factor-alpha/cachectin) plays a critical role in certain physiological defensive responses but causes severe damage to…”
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A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor by Mullberg, J, Durie, FH, Otten-Evans, C, Alderson, MR, Rose-John, S, Cosman, D, Black, RA, Mohler, KM

“…Many cytokines and soluble cytokine receptors are generated by limited proteolysis of membrane-bound precursors. We have examined the ability of the recently…”
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Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors by Zask, A., Gu, Y., Albright, J.D., Du, X., Hogan, M., Levin, J.I., Chen, J.M., Killar, L.M., Sung, A., DiJoseph, J.F., Sharr, M.A., Roth, C.E., Skala, S., Jin, G., Cowling, R., Mohler, K.M., Barone, D., Black, R., March, C., Skotnicki, J.S.

“…Potent and selective bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors were synthesized by a novel convergent route. Selectivity and efficacy versus…”
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The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups by Levin, J I, Chen, J, Du, M, Hogan, M, Kincaid, S, Nelson, F C, Venkatesan, A M, Wehr, T, Zask, A, DiJoseph, J, Killar, L M, Skala, S, Sung, A, Sharr, M, Roth, C, Jin, G, Cowling, R, Mohler, K M, Black, R A, March, C J, Skotnicki, J S

“…A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and…”
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Interleukin 10 and interferon γ regulation of experimental Trypanosoma cruzi infection by SILVA, J. S, MORRISSEY, P. J, GRABSTEIN, K. H, MOHLER, K. M, ANDERSON, D, REED, S. G

“…Studies were undertaken to determine whether interleukin 10, (IL-10) a cytokine shown to inhibit interferon gamma (IFN-gamma) production, was involved in…”
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The discovery of anthranilic acid-based mmp inhibitors. Part 3: incorporation of basic amines by Levin, J.I, Chen, J.M, Du, M.T, Nelson, F.C, Wehr, T, DiJoseph, J.F, Killar, L.M, Skala, S, Sung, A, Sharr, M.A, Roth, C.E, Jin, G, Cowling, R, Di, L, Sherman, M, Xu, Z.B, March, C.J, Mohler, K.M, Black, R.A, Skotnicki, J.S

“…Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine…”
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Induction of B cell costimulatory function by recombinant murine CD40 ligand by Kennedy, M K, Mohler, K M, Shanebeck, K D, Baum, P R, Picha, K S, Otten-Evans, C A, Janeway, Jr, C A, Grabstein, K H

“…T cell-dependent regulation of B cell growth and differentiation involves an interaction between CD40, a B cell surface molecule, and the CD40 ligand (CD40L)…”
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TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation by Peschon, Jacques J, Torrance, Dauphine S, Stocking, Kim L, Glaccum, Moira B, Otten, Carol, Willis, Cynthia R, Charrier, Keith, Morrissey, Philip J, Ware, Carol B, Mohler, Kendall M

“…The pleiotropic activities of the potent proinflammatory cytokine TNF are mediated by two structurally related, but functionally distinct, receptors, p55 and…”
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Evaluation of recombinant human soluble dimeric tumor necrosis factor receptor for prevention of OKT3-associated acute clinical syndrome by EASON, J. D, PASCUAL, M, WEE, S, FARRELL, M, PHELAN, J, BOSKOVIC, S, BLOSCH, C, MOHLER, K. M, COSIMI, A. B

“…Tumor necrosis factor alpha (TNFa) has been shown to be the primary cytokine responsible for the OKT3-induced acute clinical syndrome (OKT3-ACS). Recombinant…”
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Use of targeted anticytokine treatments in heart failure by Mohler, K M, Murray, K M, Mann, D L, Francis, G

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Differential production of IL-2 and IL-4 mRNA in vivo after primary sensitization by Mohler, KM, Butler, LD

“…The study of lymphokines has been almost entirely conducted by utilizing in vitro assay systems, long term cell lines, and clones. Thus, little information is…”
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Tolerance to class II major histocompatibility complex molecules is maintained in the presence of endogenous, interleukin-2-producing, tolerogen-specific T lymphocytes by Mohler, KM, Streilein, JW

“…We have examined the requirement for clonal reductions of tolerogen-reactive lymphocytes in mice of the A strain background rendered neonatally tolerant of…”
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Identification of a distinct low-affinity receptor for human interleukin-4 on pre-B cells by FANSLOW, W. C, SPRIGGS, M. K, RAUCH, C. T, CLIFFORD, K. N, MACDUFF, B. M, ZIEGLER, S. F, SCHOOLEY, K. A, MOHLER, K. M, MARCH, C. J, ARMITAGE, R. J

“…Biotinylated interleukin-4 (IL-4) was used to examine IL-4 receptor (IL-4R) expression on a range of human B-cell lines by flow cytometry. Using high…”
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Lymphokine production by MLR-reactive reaction lymphocytes obtained from normal mice and mice rendered tolerant of class II MHC antigens by Mohler, K M, Streilein, J W

“…A large proportion of mice rendered neonatally tolerant of class II MHC antigens respond to the tolerogen in vitro in an MLR, while simultaneously maintaining…”
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