Search Results - "Mohell, Nina"

Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT7 Receptor Agonists and Antagonists by Holmberg, Pär, Sohn, Daniel, Leideborg, Robert, Caldirola, Patrizia, Zlatoidsky, Pavel, Hanson, Sverker, Mohell, Nina, Rosqvist, Susanne, Nordvall, Gunnar, Johansson, Anette M, Johansson, Rolf

“…The understanding of the physiological role of the G-protein coupled serotonin 5-HT7 receptor is largely rudimentary. Therefore, selective and potent…”
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Neuropeptide Y‐family receptors Y6 and Y7 in chicken by Bromée, Torun, Sjödin, Paula, Fredriksson, Robert, Boswell, Tim, Larsson, Tomas A., Salaneck, Erik, Zoorob, Rima, Mohell, Nina, Larhammar, Dan

“…The peptides of the neuropeptide Y (NPY) family exert their functions, including regulation of appetite and circadian rhythm, by binding to G‐protein coupled…”
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Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives by LINNANEN, Tero, BRISANDER, Magnus, MOHELL, Nina, JOHANSSON, Anette M

“…Novel rigidified (R)-aporphine derivatives were synthesized from (R)-1,11-carbonylaporphine by ring expansion reactions. The structures of the novel analogues…”
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Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer by Fransson, Åsa, Glaessgen, Daria, Alfredsson, Jessica, Wiman, Klas G, Bajalica-Lagercrantz, Svetlana, Mohell, Nina

“…Mutation in the tumor suppressor gene TP53 is an early event in the development of high-grade serous (HGS) ovarian cancer and is identified in more than 96 %…”
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Abstract 1639: Strong synergy with APR-246 and DNA-damaging drugs in primary ovarian cancer cells by Fransson, Åsa, Glaessgen, Daria, Alfredsson, Jessica, Wiman, Klas G., Bajalica Lagercrantz, Svetlana, Mohell, Nina

“…Background: Mutations in the TP53 gene occur in at least 60% of ovarian tumors and are associated with chemoresistance and poor prognosis. APR-246 (PRIMA-1MET)…”
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Abstract 2523: Strong synergistic effects with APR-246 and cisplatin in p53-mutant lung cancer cells by Mohell, Nina, Fransson, Åsa, Alfredsson, Jessica, von Euler, Mikael, Björklund, Ulf, Abrahmsen, Lars

“…Background: Platinum compounds have been used as first-line treatment for many solid tumors including non small cell (NSCLC) and small cell (SCLC) lung cancer…”
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Abstract 270: Synergistic effect with APR-246 and standard chemotherapy in small cell lung cancer cells carrying smoking-associated TP53 mutations by Mohell, Nina, Fransson, Åsa, Alfredsson, Jessica, von Euler, Mikael, Björklund, Ulf, Abrahmsen, Lars

“…Background: Although smoking increases risk for many tumor types, no malignancy is more closely linked to tobacco exposure than small cell lung cancer (SCLC);…”
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Abstract 1801: APR-246, a clinical-stage mutant p53-reactivating compound, resensitizes ovarian cancer cells to platinum compounds and doxorubicin by Mohell, Nina, Alfredsson, Jessica, Fransson, Åsa, Bykov, Vladimir, Euler, Mikael von, Wiman, Klas, Björklund, Ulf

“…Background: Platinum-based drugs are since decades used as first-line treatment for many solid tumors. Patients with ovarian cancer often respond well to…”
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Mutagenesis and Computational Modeling of Human G‑Protein-Coupled Receptor Y2 for Neuropeptide Y and Peptide YY by Xu, Bo, Fällmar, Helena, Boukharta, Lars, Pruner, Jasna, Lundell, Ingrid, Mohell, Nina, Gutiérrez-de-Terán, Hugo, Åqvist, Johan, Larhammar, Dan

“…Neuropeptide Y and peptide YY receptor type 2 (Y2) is involved in appetite regulation and several other physiological processes. We have investigated the…”
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Abstract CT204: Preliminary results from PiSARRO, a phase Ib/II study of APR-246, a mutant p53 reactivating small molecule, in combination with standard chemotherapy in platinum-sensitive ovarian cancer by von Euler, Mikael, Wiman, Klas G., Gabra, Hani, Brenton, James D., Basu, Bristi, Vergote, Ignace, Gourley, Charlie, Smith, Austin, Alfredsson, Jessica, Mohell, Nina, Green, John A.

“…APR-246 (PRIMA-1MET) is the first clinical-stage compound that reactivates mutant p53. This phase Ib part of a proof of concept study aims to determine the…”
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Abstract 3448: Strong synergistic effects with cisplatin and APR-246, a novel compound reactivating mutant p53, in ovarian cancer cell lines and primary cells from patients by Mohell, Nina, Alfredsson, Jessica, Uustalu, Maria, Fransson, Åsa, Bykov, Vladimir J.N., Wiman, Klas G., Björklund, Ulf

“…Background: The tumor suppressor protein p53 is frequently mutated in cancer, and cancer cells carrying defects in p53 are generally more resistant to…”
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Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties by Fällmar, Helena, Sundström, Görel, Lundell, Ingrid, Mohell, Nina, Larhammar, Dan

“…The neuropeptide Y-family peptides and receptors are involved in a broad range of functions including appetite regulation. Both the peptide genes and the…”
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Interactions of human NPY/PYY C-terminal pentapeptide with the human Y2 receptor by Xu, Bo, Boukharta, Lars, Pruner, Jasna, Lundell, Ingrid, Mohell, Nina, Gutiérrez-de-Terán, Hugo, Åqvist, Johan, Larhammar, Dan

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Neuropeptide Y-family receptors Y6 and Y7 in chicken. Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region by Bromée, Torun, Sjödin, Paula, Fredriksson, Robert, Boswell, Tim, Larsson, Tomas A, Salaneck, Erik, Zoorob, Rima, Mohell, Nina, Larhammar, Dan

“…The peptides of the neuropeptide Y (NPY) family exert their functions, including regulation of appetite and circadian rhythm, by binding to G-protein coupled…”
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Neuropeptide Y‐family receptors Y 6 and Y 7 in chicken: Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region by Bromée, Torun, Sjödin, Paula, Fredriksson, Robert, Boswell, Tim, Larsson, Tomas A., Salaneck, Erik, Zoorob, Rima, Mohell, Nina, Larhammar, Dan

“…The peptides of the neuropeptide Y (NPY) family exert their functions, including regulation of appetite and circadian rhythm, by binding to G‐protein coupled…”
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Preclinical Efficacy and Toxicology Studies of APR-246, a Novel Anticancer Compound Currently In Clinical Trials for Refractory Hematological Malignancies and Prostate Cancer by Mohell, Nina, Liljebris, Charlotta, Alfredsson, Jessica, Lindman, Ylva, Uustalu, Maria, Uhlin, Thomas, Linderholm, Mats R.H., Wiman, Klas G.

“…Abstract 1806 The tumor suppressor protein p53 is a transcription factor involved in cell cycle arrest, senescence and apoptosis. The p53 gene is frequently…”
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Further Preclinical Studies with APR-246, a Novel Anticancer Compound Currently in Clinical Trials for Hematological Malignancies and Prostate Cancer by Mohell, Nina, Liljebris, Charlotta, Alfredsson, Jessica, Lindman, Ylva, Uustalu, Maria, Wiman, Klas G, Uhlin, Thomas

“…Abstract 3773 Poster Board III-709 The tumor suppressor protein p53 induces cell cycle arrest and/or apoptosis in response to various forms of cellular stress,…”
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Identification of positions in the human neuropeptide Y/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes by Fällmar, Helena, Åkerberg, Helena, Gutiérrez-de-Terán, Hugo, Lundell, Ingrid, Mohell, Nina, Larhammar, Dan

“…Abstract The members of the neuropeptide Y (NPY) family are key players in food-intake regulation. In humans this family consists of NPY, peptide YY (PYY) and…”
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Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions by Åkerberg, Helena, Fällmar, Helena, Sjödin, Paula, Boukharta, Lars, Gutiérrez-de-Terán, Hugo, Lundell, Ingrid, Mohell, Nina, Larhammar, Dan

“…Neuropeptide Y (NPY) and peptide YY (PYY) share ∼ 70% of their 36 amino acids and bind to the same three human receptor subtypes, Y1, Y2 and Y5, even though…”
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Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study by Sjödin, Paula, Holmberg, Sara K S, Akerberg, Helena, Berglund, Magnus M, Mohell, Nina, Larhammar, Dan

“…Interactions of the human NPY (neuropeptide Y) receptor Y1 with the two endogenous agonists NPY and peptide YY and two non-peptide antagonists were…”
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