Design and development of metal-organic framework-based nanocomposite hydrogels for quantification of deferiprone in exhaled breath condensate

In this study, a novel fluorescence nanoprobe based on Materials of Institute Lavoisier (MIL-101) metal-organic frameworks embedding into the agarose hydrogel is fabricated using a hydrothermal technique. It uses for sensitive quantification of deferiprone in exhaled breath condensate (EBC) samples....

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Bibliographic Details
Published in:	BMC chemistry Vol. 18; no. 1; pp. 176 - 10
Main Authors:	Moharami, Reza, Karimzadeh, Zahra, Soleymani, Jafar, Jouyban-Gharamaleki, Vahid, Khoubnasabjafari, Maryam, Rahimpour, Elaheh, Jouyban, Abolghasem
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 18-09-2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Analysis Chemistry Chemistry and Materials Science Chemistry/Food Science Composition Condensates Deferiprone Diffraction Exhaled breath condensate Fluorescence Fluorescence nanoprobe Fourier transforms Gels (Pharmacy) Hydrogels Infrared analysis Infrared spectroscopy Iron Light diffraction Luminous intensity Metal-organic frameworks MIL-101 MOF Nanocomposite hydrogel Nanocomposites Photon correlation spectroscopy Production processes X ray powder diffraction X-rays Iran Nanocomposite hydrogel Deferiprone MIL-101 MOF Exhaled breath condensate Fluorescence nanoprobe
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Summary:	In this study, a novel fluorescence nanoprobe based on Materials of Institute Lavoisier (MIL-101) metal-organic frameworks embedding into the agarose hydrogel is fabricated using a hydrothermal technique. It uses for sensitive quantification of deferiprone in exhaled breath condensate (EBC) samples. The morphology and characterization of MIL-101/agarose nanocomposite hydrogel is studied by transmission electron microscopy, dynamic light scattering instrument, powder X-ray diffraction analysis, and Fourier transform infrared spectroscopy. The probe shows a reasonable fluorescence intensity quenching in the presence of deferiprone due to the interactions between iron centers in MIL-101 (Fe) and deferiprone, which likely form non-fluorescent complexes. The proposed nanoprobe demonstrates a linear calibration curve from 0.005 to 1.5 µg mL − 1 with a detection limit of 0.003 µg mL − 1 . The intra- and inter-day precision of the reported method are 0.3% and 0.4% ( n = 5, deferiprone concentration = 1.0 µg mL − 1 ), respectively. This method demonstrates high sensitivity and specificity towards deferiprone in the EBC samples and also presents a sensing platform with simplicity, convenience, fast implementation, and cost-effective in medical monitoring.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2661-801X 2661-801X
DOI:	10.1186/s13065-024-01294-0