Search Results - "Mohapatra, Bhopal C."

An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses by Penn, Bennett H., Netter, Zoe, Johnson, Jeffrey R., Von Dollen, John, Jang, Gwendolyn M., Johnson, Tasha, Ohol, Yamini M., Maher, Cyrus, Bell, Samantha L., Geiger, Kristina, Golovkine, Guillaume, Du, Xiaotang, Choi, Alex, Parry, Trevor, Mohapatra, Bhopal C., Storck, Matthew D., Band, Hamid, Chen, Chen, Jäger, Stefanie, Shales, Michael, Portnoy, Dan A., Hernandez, Ryan, Coscoy, Laurent, Cox, Jeffery S., Krogan, Nevan J.

“…Although macrophages are armed with potent antibacterial functions, Mycobacterium tuberculosis (Mtb) replicates inside these innate immune cells. Determinants…”
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CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies by Lv, Kaosheng, Jiang, Jing, Donaghy, Ryan, Riling, Christopher R, Cheng, Ying, Chandra, Vemika, Rozenova, Krasimira, An, Wei, Mohapatra, Bhopal C, Goetz, Benjamin T, Pillai, Vinodh, Han, Xu, Todd, Emily A, Jeschke, Grace R, Langdon, Wallace Y, Kumar, Suresh, Hexner, Elizabeth O, Band, Hamid, Tong, Wei

“…Janus kinase 2 (JAK2) is a central kinase in hematopoietic stem/progenitor cells (HSPCs), and its uncontrolled activation is a prominent oncogenic driver of…”
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GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior by Bhat, Aaqib M., Mohapatra, Bhopal C., Luan, Haitao, Mushtaq, Insha, Chakraborty, Sukanya, Kumar, Siddhartha, Wu, Wangbin, Nolan, Ben, Dutta, Samikshan, Storck, Matthew D., Schott, Micah, Meza, Jane L., Lele, Subodh M., Lin, Ming-Fong, Cook, Leah M., Corey, Eva, Morrissey, Colm, Coulter, Donald W., Rowley, M. Jordan, Natarajan, Amarnath, Datta, Kaustubh, Band, Vimla, Band, Hamid

“…While better management of loco-regional prostate cancer (PC) has greatly improved survival, advanced PC remains a major cause of cancer deaths. Identification…”
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EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry by Luan, Haitao, Bielecki, Timothy A, Mohapatra, Bhopal C, Islam, Namista, Mushtaq, Insha, Bhat, Aaqib M, Mirza, Sameer, Chakraborty, Sukanya, Raza, Mohsin, Storck, Matthew D, Toss, Michael S, Meza, Jane L, Thoreson, Wallace B, Coulter, Donald W, Rakha, Emad A, Band, Vimla, Band, Hamid

“…With nearly all cancer deaths a result of metastasis, elucidating novel pro-metastatic cellular adaptations could provide new therapeutic targets. Here, we…”
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T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation by Vos, Winnie G, van Os, Bram W, den Toom, Myrthe, Beckers, Linda, van Roomen, Cindy P A A, van Tiel, Claudia M, Mohapatra, Bhopal C, Band, Hamid, Nitz, Katrin, Weber, Christian, Atzler, Dorothee, de Winther, Menno P J, Bosmans, Laura A, Lutgens, Esther, Seijkens, Tom T P

“…Atherosclerosis is a lipid-driven inflammatory disease of the arterial wall, and the underlying cause of the majority of cardiovascular diseases. Recent…”
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Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene by Nadeau, Scott A., An, Wei, Mohapatra, Bhopal C., Mushtaq, Insha, Bielecki, Timothy A., Luan, Haitao, Zutshi, Neha, Ahmad, Gulzar, Storck, Matthew D., Sanada, Masashi, Ogawa, Seishi, Band, Vimla, Band, Hamid

“…Mutations of the tyrosine kinase-directed ubiquitin ligase CBL cause myeloid leukemias, but the molecular determinants of the dominant leukemogenic activity of…”
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Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development by Bhattacharyya, Sohinee, Rainey, Mark A, Arya, Priyanka, Mohapatra, Bhopal C., Mushtaq, Insha, Dutta, Samikshan, George, Manju, Storck, Matthew D., McComb, Rodney D., Muirhead, David, Todd, Gordon L., Gould, Karen, Datta, Kaustubh, Waes, Janee Gelineau-van, Band, Vimla, Band, Hamid

“…Members of the four-member C-terminal EPS15-Homology Domain-containing (EHD) protein family play crucial roles in endocytic recycling of cell surface receptors…”
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EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis by Chakraborty, Sukanya, Bhat, Aaqib M., Mushtaq, Insha, Luan, Haitao, Kalluchi, Achyuth, Mirza, Sameer, Storck, Matthew D., Chaturvedi, Nagendra, Lopez-Guerrero, Jose Antonio, Llombart-Bosch, Antonio, Machado, Isidro, Scotlandi, Katia, Meza, Jane L., Ghosal, Gargi, Coulter, Donald W., Jordan Rowley, M., Band, Vimla, Mohapatra, Bhopal C., Band, Hamid

“…Overexpression of the EPS15 Homology Domain containing 1 (EHD1) protein has been linked to tumorigenesis but whether its core function as a regulator of…”
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The endocytic recycling regulatory protein EHD1 Is required for ocular lens development by Arya, Priyanka, Rainey, Mark A., Bhattacharyya, Sohinee, Mohapatra, Bhopal C., George, Manju, Kuracha, Murali R., Storck, Matthew D., Band, Vimla, Govindarajan, Venkatesh, Band, Hamid

“…The C-terminal Eps15 homology domain-containing (EHD) proteins play a key role in endocytic recycling, a fundamental cellular process that ensures the return…”
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Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance by Zutshi, Neha, Mohapatra, Bhopal C., Mondal, Pinaki, An, Wei, Goetz, Benjamin T., Wang, Shuo, Li, Sicong, Storck, Matthew D., Mercer, David F., Black, Adrian R., Thayer, Sarah P., Black, Jennifer D., Lin, Chi, Band, Vimla, Band, Hamid

“…Receptor tyrosine kinases (RTKs) control stem cell maintenance vs. differentiation decisions. Casitas B-lineage lymphoma (CBL) family ubiquitin ligases are…”
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Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism by Mohapatra, Bhopal C, Mirza, Sameer, Bele, Aditya, Gurumurthy, Channabasavaiah B, Raza, Mohsin, Saleem, Irfana, Storck, Matthew D, Sarkar, Aniruddha, Kollala, Sai Sundeep, Shukla, Surendra K, Southekal, Siddesh, Wagner, Kay-Uwe, Qiu, Fang, Lele, Subodh M, Alsaleem, Mansour A, Rakha, Emad A, Guda, Chittibabu, Singh, Pankaj K, Cardiff, Robert D, Band, Hamid, Band, Vimla

“…Ecdysoneless (ECD) protein is essential for embryogenesis, cell-cycle progression, and cellular stress mitigation with an emerging role in mRNA biogenesis. We…”
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EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling by Tom, Eric C., Mushtaq, Insha, Mohapatra, Bhopal C., Luan, Haitao, Bhat, Aaqib M., Zutshi, Neha, Chakraborty, Sukanya, Islam, Namista, Arya, Priyanka, Bielecki, Timothy A., Iseka, Fany M., Bhattacharyya, Sohinee, Cypher, Luke R., Goetz, Benjamin T., Negi, Simarjeet K., Storck, Matthew D., Rana, Sandeep, Barnekow, Angelika, Singh, Pankaj K., Ying, Guoguang, Guda, Chittibabu, Natarajan, Amarnath, Band, Vimla, Band, Hamid

“…Epidermal growth factor receptor (EGFR) is a prototype receptor tyrosine kinase and an oncoprotein in many solid tumors. Cell surface display of EGFR is…”
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CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation by Luan, Haitao, Bailey, Tameka A., Clubb, Robert J., Mohapatra, Bhopal C., Bhat, Aaqib M., Chakraborty, Sukanya, Islam, Namista, Mushtaq, Insha, Storck, Matthew D., Raja, Srikumar M., Band, Vimla, Band, Hamid

“…Overexpression of the epidermal growth factor receptor (EGFR) family member ErbB2 (HER2) drives oncogenesis in up to 25% of invasive breast cancers. ErbB2…”
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Discrimination of tumor from normal tissues in a mouse model of breast cancer using CARS spectroscopy combined with PC‐DFA methodology by Huang, Xi, Yuan, Ye, Bielecki, Timothy A., Mohapatra, Bhopal C., Luan, Haitao, Silva‐Lopez, Edibaldo, West, William W., Band, Vimla, Lu, Yongfeng, Band, Hamid, Zhang, Tian C.

“…Objective methodologies to discriminate tumor from normal tissue in biopsies and resection specimens are of great interest as complementary approaches to…”
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VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease by An, Wei, Mohapatra, Bhopal C, Zutshi, Neha, Bielecki, Timothy A, Goez, Benjamin T, Luan, Haitao, Iseka, Fany, Mushtaq, Insha, Storck, Matthew D, Band, Vimla, Band, Hamid

“…CBL and CBL-B ubiquitin ligases play key roles in hematopoietic stem cell homeostasis and their aberrations are linked to leukemogenesis. Mutations of CBL,…”
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Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis by Ahmad, Gulzar, Mohapatra, Bhopal C., Schulte, Nancy A., Nadeau, Scott A., Luan, Haitao, Zutshi, Neha, Tom, Eric, Ortega-Cava, Cesar, Tu, Chun, Sanada, Masashi, Ogawa, Seishi, Toews, Myron L., Band, Vimla, Band, Hamid

“…Members of the casitas B-lineage lymphoma (Cbl) family (Cbl, Cbl-b and Cbl-c) of ubiquitin ligases serve as negative regulators of receptor tyrosine kinases…”
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Corrigendum: Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development by Bhattacharyya, Sohinee, Rainey, Mark A, Arya, Priyanka, Mohapatra, Bhopal C, Mushtaq, Insha, Dutta, Samikshan, George, Manju, Storck, Matthew D, McComb, Rodney D, Muirhead, David, Todd, Gordon L, Gould, Karen, Datta, Kaustubh, Waes, Janee Gelineau-van, Band, Vimla, Band, Hamid

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Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders by William, Basem M, An, Wei, Feng, Dan, Nadeau, Scott, Mohapatra, Bhopal C, Storck, Matthew A, Band, Vimla, Band, Hamid

“…Mutations in Cbl or Cbl-b gene occur in 10% of myeloproliferative disorder (MPD) patients and are associated with poor prognosis. Hematopoietic Cbl/Cbl-b…”
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Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy by An, Wei, Nadeau, Scott A, Mohapatra, Bhopal C, Feng, Dan, Zutshi, Neha, Storck, Matthew D, Arya, Priyanka, Talmadge, James E, Meza, Jane L, Band, Vimla, Band, Hamid

“…Cbl and Cbl-b are tyrosine kinase-directed RING finger type ubiquitin ligases (E3s) that negatively regulate cellular activation pathways. E3…”
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Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy by An, Wei, Nadeau, Scott A., Mohapatra, Bhopal C., Feng, Dan, Zutshi, Neha, Storck, Matthew D., Arya, Priyanka, Talmadge, James E., Meza, Jane L., Band, Vimla, Band, Hamid

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