Search Results - "Mohanlall, Viresh"
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Characterisation, pathogenicity and hydrolytic enzyme profiling of selected Fusarium species and their inhibition by novel coumarins
Published in Archives of microbiology (01-08-2021)“…Three Fusarium species isolated locally were characterised by the amplification of their rDNA ITS region, host specificity, and hydrolytic enzyme production…”
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Molecular and metabolic alterations of 2,3-dihydroquinazolin-4(1H)-one derivatives in prostate cancer cell lines
Published in Scientific reports (14-12-2022)“…Prostate cancer (PC) is the second most common tumor in males worldwide. The lack of effective medication and the development of multidrug resistance towards…”
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Antibacterial Screening of Gunnera perpensa-Mediated Silver Nanoparticles
Published in Journal of nanotechnology (2020)“…The biosynthesis of nanoparticles has become quite popular and has been proposed as an alternative over the tedious, expensive, and toxic physical and chemical…”
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Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme
Published in Journal of enzyme inhibition and medicinal chemistry (01-01-2021)“…A series of 1,2,3-trisubstituted indolizines (2a-2f, 3a-3d, and 4a-4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible…”
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1,2,3-Triazolyl-tetrahydropyrimidine Conjugates as Potential Sterol Carrier Protein-2 Inhibitors: Larvicidal Activity against the Malaria Vector Anopheles arabiensis and In Silico Molecular Docking Study
Published in Molecules (Basel, Switzerland) (21-04-2022)“…Alteration of insect growth regulators by the action of inhibitors is becoming an attractive strategy to combat disease-transmitting insects. In the present…”
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Crystallography, Molecular Modeling, and COX-2 Inhibition Studies on Indolizine Derivatives
Published in Molecules (Basel, Switzerland) (10-06-2021)“…The cyclooxygenase-2 (COX-2) enzyme is an important target for drug discovery and development of novel anti-inflammatory agents. Selective COX-2 inhibitors…”
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Phenotypic Array for Identification and Screening of Antifungals against Aspergillus Isolates from Respiratory Infections in KwaZulu Natal, South Africa
Published in Journal of fungi (Basel) (26-05-2023)“…The rapid emergence of invasive fungal infections correlates with the increasing population of immunocompromised individuals, with many cases leading to death…”
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Larvicidal Activities of 2-Aryl-2,3-Dihydroquinazolin -4-ones against Malaria Vector Anopheles arabiensis , In Silico ADMET Prediction and Molecular Target Investigation
Published in Molecules (Basel, Switzerland) (13-03-2020)“…Malaria, affecting all continents, remains one of the life-threatening diseases introduced by parasites that are transmitted to humans through the bites of…”
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Synthetic Mono/di-halogenated Coumarin Derivatives and Their Anticancer Properties
Published in Anti-cancer agents in medicinal chemistry (01-02-2017)“…Coumarins are naturally occurring plant metabolites and several synthetic coumarin analogues are known for their various pharmacological properties such as…”
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Corrigendum to “Antibacterial Screening of Gunnera perpensa-Mediated Silver Nanoparticles”
Published in Journal of nanotechnology (07-12-2020)“…In the article titled “Antibacterial Screening of Gunnera perpensa-Mediated Silver Nanoparticles” [1], the author Londiwe Simphiwe Mbatha was omitted from the…”
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Crystallography, in Silico Studies, and In Vitro Antifungal Studies of 2,4,5 Trisubstituted 1,2,3-Triazole Analogues
Published in Antibiotics (Basel) (01-06-2020)“…A series of 2,4,5 trisubstituted-1,2,3-triazole analogues have been screened for their antifungal activity against five fungal strains, Candida parapsilosis,…”
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Crystal structure of 1-[3,5-bis(trifluoromethyl)phenyl]-2-bromoethan-1-one
Published in Acta crystallographica. Section E, Crystallographic communications (01-06-2018)“…The title compound, C 10 H 5 BrF 6 O, synthesized via continuous stirring of 3,5-bis(trifluoromethyl) acetophenone with bromine in an acidic medium and…”
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Mass spectrometry-based metabolomics approach and in vitro assays revealed promising role of 2,3-dihydroquinazolin-4(1H)-one derivatives against colorectal cancer cell lines
Published in European journal of pharmaceutical sciences (01-03-2023)“…Colorectal cancer (CRC) is the most frequent form of gastrointestinal cancer and one of the major causes of human mortality worldwide. Many of the current CRC…”
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Crystal structure, hydrogen bonding interactions, Hirshfeld surfaces, energy frameworks, and DFT calculation of Diethyl 3-(4-substitutedbenzoyl)indolizine-1,2-dicarboxylates
Published in Journal of molecular structure (15-07-2024)“…•Indolizine derivatives with fluoro, chloro, or nitro substitutions were synthesized and characterized by FTIR, NMR, LC-MS, elemental analysis, and PXRD…”
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Larvicidal activity, molecular docking, and molecular dynamics studies of 7-(trifluoromethyl)indolizine derivatives against Anopheles arabiensis
Published in Molecular diversity (08-10-2024)“…A novel series of 7-(trifluoromethyl)indolizine derivatives (4a-4n) was synthesized using a 1,3-Dipolar cycloaddition reaction. Structure elucidation of the…”
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Design, synthesis and characterization of novel 2-(2, 3-dichlorophenyl)-5-aryl-1,3,4-oxadiazole derivatives for their anti-tubercular activity against Mycobacterium tuberculosis
Published in Chemical Data Collections (01-08-2020)“…Tuberculosis (TB) remains the leading cause of death from an infectious disease globally. The chemotherapy of TB is complicated by the protracted treatment…”
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Chemistry, anti-diabetic activity and structural analysis of substituted dihydropyrimidine analogues
Published in Journal of molecular structure (05-03-2021)“…•Synthesized a series of newly dihydropyrimidine analogues using one-pot tricomponent method.•Synthesized DHPM molecules are screened for antidiabetic activity…”
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Phenotypic Array for Identification and Screening of Antifungals against IAspergillus/I Isolates from Respiratory Infections in KwaZulu Natal, South Africa
Published in Journal of fungi (Basel) (01-05-2023)“…The rapid emergence of invasive fungal infections correlates with the increasing population of immunocompromised individuals, with many cases leading to death…”
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Identification of potent indolizine derivatives against Mycobacterial tuberculosis: In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies
Published in International journal of biological macromolecules (01-08-2024)“…In the current study, two sets of compounds: (E)-1-(2-(4-substitutedphenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium derivatives (3a-3e); and…”
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