Search Results - "Mohankumar, M."

Metformin effectively restores the HPA axis function in diet-induced obese rats by Shin, Andrew C., Balasubramanian, Priya, Suryadevara, Pavan, Zyskowski, Justin, Herdt, Thomas H., MohanKumar, Sheba M. J., MohanKumar, Puliyur S.

“…Introduction The hypothalamo-pituitary-adrenal (HPA) axis is perturbed in obesity. We previously reported presence of leptin resistance in the brainstem and…”
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Revolutionizing Antimicrobial Solutions Nanotechnology, CRISPR-Cas9 and Innovative Approaches to Combat Drug Resistance in ESKAPE Pathogens by Sachithanandan, J. Sabarish, Deepalakshmi, M, Rajamohamed, H, Mary, Priscilla, Mohankumar, M, Vikashini, S

“…Antimicrobial drug resistance within ESKAPE pathogens is a formidable global challenge, necessitating innovative solutions. This review explores a multifaceted…”
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Erythroid lineage-specific lentiviral RNAi vectors suitable for molecular functional studies and therapeutic applications by Bagchi, Abhirup, Devaraju, Nivedhitha, Chambayil, Karthik, Rajendiran, Vignesh, Venkatesan, Vigneshwaran, Sayed, Nilofer, Pai, Aswin Anand, Nath, Aneesha, David, Ernest, Nakamura, Yukio, Balasubramanian, Poonkuzhali, Srivastava, Alok, Thangavel, Saravanabhavan, Mohankumar, Kumarasamypet M., Velayudhan, Shaji R.

“…Numerous genes exert multifaceted roles in hematopoiesis. Therefore, we generated novel lineage-specific RNA interference (RNAi) lentiviral vectors,…”
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Editing of homologous globin genes by nickase-deficient base editor mitigates large intergenic deletions in HSPCs by George, Anila, Sadanandan, Poornasree, Ravi, Nithin Sam, Vaishnavi, B., Marepally, Srujan, Thangavel, Saravanbhavan, Velayudhan, Shaji R., Srivastava, Alok, Mohankumar, Kumarasamypet M

“…Recent studies have shown that base editing, even with single-strand breaks, could result in large deletions of the interstitial regions while targeting…”
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Liraglutide improves hypertension and metabolic perturbation in a rat model of polycystic ovarian syndrome by Hoang, Vanessa, Bi, Jiangjiang, Mohankumar, Sheba M, Vyas, Arpita K

“…Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, with a prevalence of 5-8%. Type 2 diabetes and…”
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Branched-Chain Amino Acids Are Linked with Alzheimer's Disease-Related Pathology and Cognitive Deficits by Siddik, Md Abu Bakkar, Mullins, Caitlyn A, Kramer, Alyssa, Shah, Harsh, Gannaban, Ritchel B, Zabet-Moghaddam, Masoud, Huebinger, Ryan M, Hegde, Vijay K, MohanKumar, Sheba M J, MohanKumar, Puliyur S, Shin, Andrew C

“…Alzheimer's disease (AD) is an irreversible neurodegenerative disorder with a complex pathophysiology. Type 2 diabetes (T2D) is a strong risk factor for AD…”
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Optimization of SARS-CoV-2 Pseudovirion Production in Lentivirus Backbone With a Novel Liposomal System by Mahalingam, Gokulnath, Rachamalla, Hari Krishnareddy, Arjunan, Porkizhi, Periyasami, Yogapriya, M, Salma, Thangavel, Saravanabhavan, Mohankumar, Kumarasamypet M, Moorthy, Mahesh, Velayudhan, Shaji R, Srivastava, Alok, Marepally, Srujan

“…Due to the fast mutating nature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the development of novel therapeutics, vaccines, and…”
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Experimental analysis of intelligent vehicle monitoring system using Internet of Things (IoT) by Thamaraimanalan, T., Mohankumar, M., Dhanasekaran, S., Anandakumar, H.

“…Internet of things is an emerging trend and Wireless sensor networks are embedded with IoT to measure various parameters of a vehicle. Measurements and…”
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Particulate matter, oxidative stress and neurotoxicity by MohanKumar, Sheba M.J., Campbell, Arezoo, Block, Michelle, Veronesi, Bellina

“…Particulate matter (PM), a component of air pollution has been epidemiologically associated with sudden deaths, cardiovascular and respiratory illnesses. The…”
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Prenatal Exposure to Bisphenol A and/or Diethylhexyl Phthalate Impacts Brain Monoamine Levels in Rat Offspring by Kaimal, Amrita, Hooversmith, Jessica M, Mansi, Maryam H Al, Holmes, Philip V, MohanKumar, Puliyur S, MohanKumar, Sheba M J

“…This study examines the sex-specific effects of gestational exposure (days 6-21) to endocrine-disrupting chemicals such as bisphenol A (BPA), diethylhexyl…”
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Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs by Ravikumar Reddy, D., Khurana, Amit, Bale, Swarna, Ravirala, Ramu, Samba Siva Reddy, V., Mohankumar, M., Godugu, Chandraiah

“…P-glycoprotein (P-gp), a well known efflux transporter in the blood brain barrier inhibits the uptake of substrate drugs into brain. The main aim of this study…”
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The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction by Evseenko, Denis A., Murthi, Padma, Paxton, James W., Reid, Glen, Emerald, B. Starling, Mohankumar, K M., Lobie, Peter E., Brennecke, Shaun P., Kalionis, Bill, Keelan, J. A.

“…ABSTRACT The efflux pump ATP binding cassette superfamily member G2 (ABCG2)/breast cancer resistance protein (BCRP) is highly expressed in human placenta. We…”
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Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats by Balasubramanian, Priya, Sirivelu, Madhu P., Weiss, Kathryn A., Wagner, James G., Harkema, Jack R., Morishita, Masako, MohanKumar, P.S., MohanKumar, Sheba M.J.

“…► There is marked activation of the paraventricular nucleus after acute exposure to PM2.5 as indicated by increases in the levels of neurotransmitters such as…”
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Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors by Prasad, Kirti, Devaraju, Nivedhitha, George, Anila, Ravi, Nithin Sam, Paul, Joshua, Mahalingam, Gokulnath, Rajendiran, Vignesh, Panigrahi, Lokesh, Venkatesan, Vigneshwaran, Lakhotiya, Kartik, Periyasami, Yogapriya, Pai, Aswin Anand, Nakamura, Yukio, Kurita, Ryo, Balasubramanian, Poonkuzhali, Thangavel, Saravanabhavan, Velayudhan, Shaji R., Newby, Gregory A., Marepally, Srujan, Srivastava, Alok, Mohankumar, Kumarasamypet M.

“…β-thalassemia/HbE results from mutations in the β-globin locus that impede the production of functional adult hemoglobin. Base editors (BEs) could facilitate…”
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Evaluation of the Central Effects of Systemic Lentiviral-Mediated Leptin Delivery in Streptozotocin-Induced Diabetic Rats by Clark, Kimberly A, Shin, Andrew C, Sirivelu, Madhu P, MohanKumar, Ramya C, Maddineni, Sreenivasa R, Ramachandran, Ramesh, MohanKumar, Puliyur S, MohanKumar, Sheba M J

“…Type 1 diabetes (T1D) is characterized by hyperphagia, hyperglycemia and activation of the hypothalamic-pituitary-adrenal (HPA) axis. We have reported…”
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Prevalence of vitamin D deficiency among South Indian pregnant women by Ravinder, S, Padmavathi, R, Maheshkumar, K, Mohankumar, M, Maruthy, K, Sankar, S, Balakrishnan, Kalpana

“…Background: Deficiency of vitamin D is widespread across the globe. Expectant women are one of the most vulnerable groups for vitamin D deficiency (VDD). Even…”
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High Fat Diet Affects Reproductive Functions in Female Diet-Induced Obese and Dietary Resistant Rats by Balasubramanian, P., Jagannathan, L., Mahaley, Rochell E, Subramanian, M., Gilbreath, E. T., MohanKumar, P. S., MohanKumar, S. M. J.

“…The incidence of ovulatory disorders is common in obese animal models. The mechanism behind this effect is unclear. We hypothesised that a high‐fat (HF) diet…”
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PERFORMANCE ANALYSIS OF VARIOUS ARTIFICIAL INTELLIGENT NEURAL NETWORKS FOR GPS/INS INTEGRATION by Malleswaran, M., Vaidehi, V., Saravanaselvan, A., Mohankumar, M.

“…An aircraft system mainly relies on a Global Positioning System (GPS) to provide accurate position values consistently. However, GPS receivers may encounter…”
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Multi-sink Optimal Repositioning for Energy and Power Optimization in Wireless Sensor Networks by Yasotha, S., Gopalakrishnan, V., Mohankumar, M.

“…A wireless sensor network (WSN) plays a major role in many recent applications now such as surveillance and security, target tracking, agriculture, health and…”
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Chronic estradiol treatment decreases Brain Derived Neurotrophic Factor (BDNF) expression and monoamine levels in the amygdala – Implications for behavioral disorders by Balasubramanian, Priya, Subramanian, Madhan, Nunez, Joseph L., MohanKumar, Sheba M.J., MohanKumar, P.S.

“…Changes in serum estradiol levels are associated with mood disorders in women. However, the underlying mechanisms are not clear. Because alterations in…”
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