The preclinical and clinical implications of fetal adnexa derived mesenchymal stromal cells in wound healing therapy

Mesenchymal stromal cells (MSCs) isolated from fetal adnexa namely amniotic membrane/epithelium, amniotic fluid and umbilical cord have hogged the limelight in recent times, as a proposed alternative to MSCs from conventional sources. These cells which are identified as being in a developmentally pr...

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Bibliographic Details
Published in:	Wound repair and regeneration Vol. 29; no. 3; pp. 347 - 369
Main Authors:	Mankuzhy, Pratheesh D., Ramesh, Sreekumar T., Thirupathi, Yasotha, Mohandas, Ponny S., Chandra, Vikash, Sharma, Taru Guttula
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01-05-2021
Subjects:	Cell Differentiation Cell Proliferation Humans Mesenchymal Stem Cells Secretome Umbilical Cord Wound Healing
Online Access:	Get full text
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Summary:	Mesenchymal stromal cells (MSCs) isolated from fetal adnexa namely amniotic membrane/epithelium, amniotic fluid and umbilical cord have hogged the limelight in recent times, as a proposed alternative to MSCs from conventional sources. These cells which are identified as being in a developmentally primitive state have many advantages, the most important being the non‐invasive nature of their isolation procedures, absence of ethical concerns, proliferation potential, differentiation abilities and low immunogenicity. In the present review, we are focusing on the potential preclinical and clinical applications of different cell types of fetal adnexa, in wound healing therapy. We also discuss the isolation‐culture methods, cell surface marker expression, multi‐lineage differentiation abilities, immune‐modulatory capabilities and their homing property. Different mechanisms involved in the wound healing process and the role of stromal cells in therapeutic wound healing are highlighted. Further, we summarize the findings of the cell delivery systems in skin lesion models and paracrine functions of their secretome in the wound healing process. Overall, this holistic review outlines the research findings of fetal adnexa derived MSCs, their usefulness in wound healing therapy in human as well as in veterinary medicine.
Bibliography:	Name of the institution to which work is attributed: ICAR‐Indian Veterinary Research Institute, Izzatnagar, UP, India. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1067-1927 1524-475X
DOI:	10.1111/wrr.12911