Search Results - "Mohanalakshmi, Narasumani"
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1
Identification of natural compound inhibitors for multidrug efflux pumps of Escherichia coli and Pseudomonas aeruginosa using in silico high-throughput virtual screening and in vitro validation
Published in PloS one (15-07-2014)“…Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics rendering the treatment of infections very difficult. A main mechanism…”
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Journal Article -
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Discerning evolutionary trends in post-translational modification and the effect of intrinsic disorder: Analysis of methylation, acetylation and ubiquitination sites in human proteins
Published in PLoS computational biology (01-08-2018)“…Intrinsically disordered regions (IDRs) of proteins play significant biological functional roles despite lacking a well-defined 3D structure. For example, IDRs…”
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Journal Article -
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Bioinformatical parsing of folding-on-binding proteins reveals their compositional and evolutionary sequence design
Published in Scientific reports (18-12-2015)“…Intrinsic disorder occurs when (part of) a protein remains unfolded during normal functioning. Intrinsically-disordered regions can contain segments that ‘fold…”
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Journal Article -
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Bioinformatical Analysis of Intrinsically Disordered Regions in Eukaryotes: Insights into the Evolution of Folding-on-Binding Regions and Post-translational Modifications
Published 01-01-2018“…Intrinsically disordered proteins (IDPs) or Intrinsically disordered regions (IDRs) in proteins can exhibit a partially folded or unfolded state under…”
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Dissertation