Search Results - "Mohanakumar, Kochupurackal P"

Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson’s Disease by Dutta, Debashis, Ali, Nilufar, Banerjee, Emili, Singh, Raghavendra, Naskar, Amit, Paidi, Ramesh Kumar, Mohanakumar, Kochupurackal P

“…Since substantia nigra (SN) and ventral tegmental area (VTA) dopaminergic neurons are, respectively, susceptible or largely unaffected in Parkinson’s disease…”
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Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3‐Nitropropionic Acid‐Induced Rat Model of Huntington's Disease by Chakraborty, Joy, Singh, Raghavendra, Dutta, Debashis, Naskar, Amit, Rajamma, Usha, Mohanakumar, Kochupurackal P.

“…Summary Aim Huntington's disease (HD) is an autosomal dominant disorder, for which clinically available drugs offer only symptomatic relief. These prescription…”
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Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents by Borah, Anupom, Mohanakumar, Kochupurackal P.

“…:  We tested the hypothesis that melatonin regulates formation of 6‐hydroxydopamine (6‐OHDA) in the brain and thereby protects animals from dopaminergic…”
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Quality of life and concerns of parkinson's disease patients and their caregivers during COVID-19 pandemic: An indian study by Banerjee, Sourav, Mukherjee, Adreesh, Bhattacharyya, Bidisha, Mohanakumar, Kochupurackal, Biswas, Atanu

“…Objectives: Parkinson's disease (PD) patients have suffered during the coronavirus disease 2019 pandemic, with worsening of both motor and nonmotor symptoms…”
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Mitochondrial Deficits Accompany Cognitive Decline Following Single Bilateral Intracerebroventricular Streptozotocin by Paidi, Ramesh K, Nthenge-Ngumbau, Dominic N, Singh, Raghavendra, Kankanala, Thulasi, Mehta, Hina, Mohanakumar, Kochupurackal P

“…Bilateral intracerebroventricular (ICV) administration of streptozotocin (STZ) causes Alzheimer's disease (AD)-type neurodegeneration in rats. The model is…”
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Effect of COVID-19 related lockdown on nonmotor symptoms of Parkinson's disease by Banerjee, Sourav, Mukherjee, Adreesh, Mohanakumar, Kochupurackal, Biswas, Atanu

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Gender-Specific Effect of 5-HT and 5-HIAA on Threshold Level of Behavioral Symptoms and Sex-Bias in Prevalence of Autism Spectrum Disorder by Chakraborti, Barnali, Verma, Deepak, Guhathakurta, Subhrangshu, Jaiswal, Preeti, Singh, Asem Surindro, Sinha, Swagata, Ghosh, Saurabh, Mukhopadhyay, Kanchan, Mohanakumar, Kochupurackal P, Rajamma, Usha

“…Platelet hyperserotonemia in a subset of Autism Spectrum Disorder (ASD) probands, efficacy of selective serotonin reuptake inhibitors (SSRIs) in reducing…”
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Attention deficit-hyperactivity disorder suffers from mitochondrial dysfunction by Verma, Poonam, Singh, Alpana, Nthenge-Ngumbau, Dominic Ngima, Rajamma, Usha, Sinha, Swagata, Mukhopadhyay, Kanchan, Mohanakumar, Kochupurackal P

“…Pathophysiology of attention-deficit hyperactivity disorder (ADHD) is not known, and therefore the present study investigated mitochondrial defects, if any in…”
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Engraftment of mouse embryonic stem cells differentiated by default leads to neuroprotection, behaviour revival and astrogliosis in parkinsonian rats by Tripathy, Debasmita, Haobam, Reena, Nair, Ranju, Mohanakumar, Kochupurackal P

“…We report here protection against rotenone-induced behavioural dysfunction, striatal dopamine depletion and nigral neuronal loss, following intra-striatal…”
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Pilot study indicate role of preferentially transmitted monoamine oxidase gene variants in behavioral problems of male ADHD probands by Karmakar, Arijit, Goswami, Rishov, Saha, Tanusree, Maitra, Subhamita, Roychowdhury, Anirban, Panda, Chinmay Kumar, Sinha, Swagata, Ray, Anirban, Mohanakumar, Kochupurackal P, Rajamma, Usha, Mukhopadhyay, Kanchan

“…Attention deficit hyperactivity disorder (ADHD) is an etiologically complex childhood onset neurobehavioral disorder characterized by age-inappropriate…”
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Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease by Saravanan, Karuppagounder S., Sindhu, Kizhakke M., Mohanakumar, Kochupurackal P.

“…We examined in Sprague–Dawley rats whether intranigral administration of complex-I inhibitor, rotenone, produces biochemical lesions in the striatum similar to…”
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Embryonic stem cells derived neuron transplantation recovery in models of parkinsonism in relation to severity of the disorder in rats by Haobam, Reena, Tripathy, Debasmita, Kaidery, Navneet A, Mohanakumar, Kochupurackal P

“…6-Hydroxydopamine (6-OHDA)- and 1-methyl-4-phenylpyridinium (MPP(+))-induced hemi-parkinsonism was investigated in relation to the severity of the disorder in…”
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Swim-test as a function of motor impairment in MPTP model of Parkinson's disease: A comparative study in two mouse strains by Haobam, Reena, Sindhu, Kizhakke M., Chandra, Goutam, Mohanakumar, Kochupurackal P.

“…Parkinson's disease (PD) is a common neurodegenerative disease that exhibits motor dysfunctions, such as tremor, akinesia and rigidity. In the present study,…”
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Can Cyclic Nucleotide Phosphodiesterase Inhibitors Be Drugs for Parkinson’s Disease? by Nthenge-Ngumbau, Dominic Ngima, Mohanakumar, Kochupurackal P.

“…Parkinson’s disease (PD) has no known cure; available therapies are only capable of offering temporary, symptomatic relief to the patients. Varied therapeutic…”
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Efficacy of defensins as neutralizing agents against the deadly SARS-CoV-2 by Deepthi, Varughese, Mohanakumar, Kochupurackal P, Rajamma, Usha

“…SARS-CoV-2 infection causes asymptomatic to severe human respiratory diseases. Vaccinations are effective only to a certain extent, and the disease recurs with…”
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The light at the end of the tunnel gets vivid for spinal muscular atrophy: An Editorial Highlight for "Cerebrospinal fluid proteomic profiling in nusinersen-treated patients with spinal muscular atrophy" on page 650 by Dutta, Debashis, Chandra, Goutam, Mohanakumar, Kochupurackal P

“…Kessler et al. in this current issue have attempted to discern biomarker(s) for spinal muscular atrophy (SMA) by assessing alterations in cerebrospinal fluid…”
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Nimodipine, an L-type calcium channel blocker attenuates mitochondrial dysfunctions to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice by Singh, Alpana, Verma, Poonam, Balaji, Gillela, Samantaray, Supriti, Mohanakumar, Kochupurackal P.

“…Parkinson’s disease (PD), the most common progressive neurodegenerative movement disorder, results from loss of dopaminergic neurons of substantia nigra pars…”
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Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice by Naskar, Amit, Prabhakar, Visakh, Singh, Raghavendra, Dutta, Debashis, Mohanakumar, Kochupurackal P.

“…L‐3,4‐dihydroxyphenylalanine (L‐DOPA) reduces symptoms of Parkinson's disease (PD), but suffers from serious side effects on long‐term use. Melatonin…”
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Tea and Parkinson's disease: Constituents of tea synergize with antiparkinsonian drugs to provide better therapeutic benefits by Dutta, Debashis, Mohanakumar, Kochupurackal P.

“…The major neurodegenerative movement disorder Parkinson's disease (PD) is characterized by rest-tremor, akinesia, rigidity and inability to initiate movements…”
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Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders by Jaiswal, Preeti, Mohanakumar, Kochupurackal P, Rajamma, Usha

“…Serotonergic system has long been implicated in the aetiology of autism spectrum disorders (ASD), since platelet hyperserotonemia is consistently observed in a…”
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