Search Results - "Mohanakumar, Kochupurackal"

Can Cyclic Nucleotide Phosphodiesterase Inhibitors Be Drugs for Parkinson’s Disease? by Nthenge-Ngumbau, Dominic Ngima, Mohanakumar, Kochupurackal P.

“…Parkinson’s disease (PD) has no known cure; available therapies are only capable of offering temporary, symptomatic relief to the patients. Varied therapeutic…”
Get full text

Efficacy of defensins as neutralizing agents against the deadly SARS-CoV-2 by Deepthi, Varughese, Mohanakumar, Kochupurackal P, Rajamma, Usha

“…SARS-CoV-2 infection causes asymptomatic to severe human respiratory diseases. Vaccinations are effective only to a certain extent, and the disease recurs with…”
Get full text

The light at the end of the tunnel gets vivid for spinal muscular atrophy: An Editorial Highlight for "Cerebrospinal fluid proteomic profiling in nusinersen-treated patients with spinal muscular atrophy" on page 650 by Dutta, Debashis, Chandra, Goutam, Mohanakumar, Kochupurackal P

“…Kessler et al. in this current issue have attempted to discern biomarker(s) for spinal muscular atrophy (SMA) by assessing alterations in cerebrospinal fluid…”
Get full text

Nimodipine, an L-type calcium channel blocker attenuates mitochondrial dysfunctions to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice by Singh, Alpana, Verma, Poonam, Balaji, Gillela, Samantaray, Supriti, Mohanakumar, Kochupurackal P.

“…Parkinson’s disease (PD), the most common progressive neurodegenerative movement disorder, results from loss of dopaminergic neurons of substantia nigra pars…”
Get full text

Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice by Naskar, Amit, Prabhakar, Visakh, Singh, Raghavendra, Dutta, Debashis, Mohanakumar, Kochupurackal P.

“…L‐3,4‐dihydroxyphenylalanine (L‐DOPA) reduces symptoms of Parkinson's disease (PD), but suffers from serious side effects on long‐term use. Melatonin…”
Get full text

Tea and Parkinson's disease: Constituents of tea synergize with antiparkinsonian drugs to provide better therapeutic benefits by Dutta, Debashis, Mohanakumar, Kochupurackal P.

“…The major neurodegenerative movement disorder Parkinson's disease (PD) is characterized by rest-tremor, akinesia, rigidity and inability to initiate movements…”
Get full text

Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders by Jaiswal, Preeti, Mohanakumar, Kochupurackal P, Rajamma, Usha

“…Serotonergic system has long been implicated in the aetiology of autism spectrum disorders (ASD), since platelet hyperserotonemia is consistently observed in a…”
Get full text

Quality of life and concerns of parkinson's disease patients and their caregivers during COVID-19 pandemic: An indian study by Banerjee, Sourav, Mukherjee, Adreesh, Bhattacharyya, Bidisha, Mohanakumar, Kochupurackal, Biswas, Atanu

“…Objectives: Parkinson's disease (PD) patients have suffered during the coronavirus disease 2019 pandemic, with worsening of both motor and nonmotor symptoms…”
Get full text

Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson’s Disease by Dutta, Debashis, Ali, Nilufar, Banerjee, Emili, Singh, Raghavendra, Naskar, Amit, Paidi, Ramesh Kumar, Mohanakumar, Kochupurackal P

“…Since substantia nigra (SN) and ventral tegmental area (VTA) dopaminergic neurons are, respectively, susceptible or largely unaffected in Parkinson’s disease…”
Get full text

Neuro-nutraceuticals: Natural products nourish the brain but be aware of contrary effects by Williams, Robert J., Mohanakumar, Kochupurackal P., Beart, Philip M.

“…In this Special Issue on “Nutraceuticals: Molecular and Functional Insights into how Natural Products Nourish the Brain”, the editors bring together…”
Get full text

Mitochondrial Deficits Accompany Cognitive Decline Following Single Bilateral Intracerebroventricular Streptozotocin by Paidi, Ramesh K, Nthenge-Ngumbau, Dominic N, Singh, Raghavendra, Kankanala, Thulasi, Mehta, Hina, Mohanakumar, Kochupurackal P

“…Bilateral intracerebroventricular (ICV) administration of streptozotocin (STZ) causes Alzheimer's disease (AD)-type neurodegeneration in rats. The model is…”
Get more information

Effect of COVID-19 related lockdown on nonmotor symptoms of Parkinson's disease by Banerjee, Sourav, Mukherjee, Adreesh, Mohanakumar, Kochupurackal, Biswas, Atanu

Get full text

Nimodipine attenuates the parkinsonian neurotoxin, MPTP-induced changes in the calcium binding proteins, calpain and calbindin by Singh, Alpana, Verma, Poonam, Raju, Anu, Mohanakumar, Kochupurackal P.

“…•Ca2+ regulatory proteins are affected in cellular & animal models of parkinsonism.•Calpain level is elevated, calbindin is reduced both in vitro &in vivo PD…”
Get full text

Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3‐Nitropropionic Acid‐Induced Rat Model of Huntington's Disease by Chakraborty, Joy, Singh, Raghavendra, Dutta, Debashis, Naskar, Amit, Rajamma, Usha, Mohanakumar, Kochupurackal P.

“…Summary Aim Huntington's disease (HD) is an autosomal dominant disorder, for which clinically available drugs offer only symptomatic relief. These prescription…”
Get full text

Aging and Neurodegeneration: A Tangle of Models and Mechanisms by Chakrabarti, Sasanka, Mohanakumar, Kochupurackal P

“…The research on aging and age-related diseases, especially the neurodegenerative diseases, is on the fast track. However, the results have so far not been…”
Get full text

Neuro-nutraceuticals: The path to brain health via nourishment is not so distant by Williams, Robert J., Mohanakumar, Kochupurackal P., Beart, Philip M.

“…In this Special Issue on “Nutraceuticals: Molecular and Functional Insights into how Natural Products Nourish the Brain”, the editors bring together…”
Get full text

Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents by Borah, Anupom, Mohanakumar, Kochupurackal P.

“…:  We tested the hypothesis that melatonin regulates formation of 6‐hydroxydopamine (6‐OHDA) in the brain and thereby protects animals from dopaminergic…”
Get full text

Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease by Govindarajulu, Manoj, Ramesh, Sindhu, Neel, Logan, Fabbrini, Mary, Buabeid, Manal, Fujihashi, Ayaka, Dwyer, Darby, Lynd, Tyler, Shah, Karishma, Mohanakumar, Kochupurackal P., Smith, Forrest, Moore, Timothy, Dhanasekaran, Muralikrishnan

“…Alzheimer's disease (AD) is the most common neurodegenerative disease, and its incidence is increasing worldwide with increased lifespan. Currently, there is…”
Get full text

Engraftment of mouse embryonic stem cells differentiated by default leads to neuroprotection, behaviour revival and astrogliosis in parkinsonian rats by Tripathy, Debasmita, Haobam, Reena, Nair, Ranju, Mohanakumar, Kochupurackal P

“…We report here protection against rotenone-induced behavioural dysfunction, striatal dopamine depletion and nigral neuronal loss, following intra-striatal…”
Get full text

Melatonin synergizes with low doses of L-DOPA to improve dendritic spine density in the mouse striatum in experimental Parkinsonism by Naskar, Amit, Manivasagam, Thamilarasan, Chakraborty, Joy, Singh, Raghavendra, Thomas, Bobby, Dhanasekaran, Muralikrishnan, Mohanakumar, Kochupurackal P

“…The dopamine precursor, L‐3,4‐dihydroxyphenylalanine (L‐DOPA), is the preferred drug for Parkinson's disease, but long‐term treatment results in the…”
Get full text