Search Results - "Mohan, Ramkumar"

Large gallstone initially diagnosed as porcelain gallbladder with malignant change by Mohan, Ramkumar, Shelat, Vishalkumar G, Junnarkar, Sameer P

“…Correspondence to Mr Ramkumar Mohan, Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore; m.ramkumar@u.nus.edu Case presentation A…”
Get full text

microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3 by Wang, Zhihong, Mohan, Ramkumar, Chen, Xinqian, Matson, Katy, Waugh, Jackson, Mao, Yiping, Zhang, Shungang, Li, Wanzhen, Tang, Xiaohu, Satin, Leslie S, Tang, Xiaoqing

“…Pancreatic β-cell dysfunction is central to the development and progression of type 2 diabetes. Dysregulation of microRNAs (miRNAs) has been associated with…”
Get full text

Role of nutrient-driven O-GlcNAc-post-translational modification in pancreatic exocrine and endocrine islet development by Baumann, Daniel, Wong, Alicia, Akhaphong, Brian, Jo, Seokwon, Pritchard, Samantha, Mohan, Ramkumar, Chung, Grace, Zhang, Ying, Alejandro, Emilyn U

“…Although the developing pancreas is exquisitely sensitive to nutrient supply , it is not entirely clear how nutrient-driven post-translational modification of…”
Get full text

OGT Regulates Mitochondrial Biogenesis and Function via Diabetes Susceptibility Gene Pdx1 by Mohan, Ramkumar, Jo, Seokwon, Lockridge, Amber, Ferrington, Deborah A, Murray, Kevin, Eschenlauer, Arthur, Bernal-Mizrachi, Ernesto, Fujitani, Yoshio, Alejandro, Emilyn U

“…-GlcNAc transferase (OGT), a nutrient sensor sensitive to glucose flux, is highly expressed in the pancreas. However, the role of OGT in the mitochondria of…”
Get full text

Robotic versus laparoscopic ventral hernia repair: a systematic review and meta-analysis of randomised controlled trials and propensity score matched studies by Mohan, Ramkumar, Yeow, Marcus, Wong, Joel Yat Seng, Syn, Nicholas, Wijerathne, Sujith, Lomanto, Davide

“…Purpose There has not been a consensus on the superiority of a surgical approach for minimally invasive ventral hernia repair. This systematic review and…”
Get full text

Synaptotagmin‐7 enhances calcium‐sensing of chromaffin cell granules and slows discharge of granule cargos by Bendahmane, Mounir, Morales, Alina, Kreutzberger, Alex J. B., Schenk, Noah A., Mohan, Ramkumar, Bakshi, Shreeya, Philippe, Julie M., Zhang, Shuang, Kiessling, Volker, Tamm, Lukas K., Giovannucci, David R., Jenkins, Paul M., Anantharam, Arun

“…Synaptotagmin‐7 (Syt‐7) is one of two major calcium sensors for exocytosis in adrenal chromaffin cells, the other being synaptotagmin‐1 (Syt‐1). Despite a…”
Get full text

Transgenic overexpression of microRNA-30d in pancreatic beta-cells progressively regulates beta-cell function and identity by Mao, Yiping, Schoenborn, Jacob, Wang, Zhihong, Chen, Xinqian, Matson, Katy, Mohan, Ramkumar, Zhang, Shungang, Tang, Xiaohu, Arunagiri, Anoop, Arvan, Peter, Tang, Xiaoqing

“…Abnormal microRNA functions are closely associated with pancreatic β-cell loss and dysfunction in type 2 diabetes. Dysregulation of miR-30d has been reported…”
Get full text

Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2 by Lockridge, Amber, Jo, Seokwon, Gustafson, Eric, Damberg, Niklas, Mohan, Ramkumar, Olson, Miranda, Abrahante, Juan E., Alejandro, Emilyn U.

“…During early obesity, pancreatic β cells compensate for increased metabolic demand through a transient phase of insulin hypersecretion that stabilizes blood…”
Get full text

Urinary Biomarkers and Renal Recovery in Critically Ill Patients with Renal Support by Srisawat, Nattachai, Wen, Xiaoyan, Lee, Minjae, Kong, Lan, Elder, Michele, Carter, Melinda, Unruh, Mark, Finkel, Kevin, Vijayan, Anitha, Ramkumar, Mohan, Paganini, Emil, Singbartl, Kai, Palevsky, Paul M, Kellum, John A

“…Despite significant advances in the epidemiology of acute kidney injury (AKI), prognostication remains a major clinical challenge. Unfortunately, no reliable…”
Get full text

TissueGrinder, a novel technology for rapid generation of patient-derived single cell suspensions from solid tumors by mechanical tissue dissociation by Scheuermann, Stefan, Lehmann, Jonas M, Ramani Mohan, Ramkumar, Reißfelder, Christoph, Rückert, Felix, Langejürgen, Jens, Pallavi, Prama

“…Recent advances hold promise of making personalized medicine a step closer to implementation in clinical settings. However, traditional sample preparation…”
Get full text

Placental Insulin Receptor Transiently Regulates Glucose Homeostasis in the Adult Mouse Offspring of Multiparous Dams by Chung, Grace, Mohan, Ramkumar, Beetch, Megan, Jo, Seokwon, Alejandro, Emilyn Uy

“…In pregnancies complicated by maternal obesity and gestational diabetes mellitus, there is strong evidence to suggest that the insulin signaling pathway in the…”
Get full text

Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice by Akhaphong, Brian, Baumann, Daniel C, Beetch, Megan, Lockridge, Amber D, Jo, Seokwon, Wong, Alicia, Zemanovic, Tate, Mohan, Ramkumar, Fondevilla, Danica L, Sia, Michelle, Pineda-Cortel, Maria Ruth B, Alejandro, Emilyn U

“…Fetal growth restriction, or low birth weight, is a strong determinant for eventual obesity and type 2 diabetes. Clinical studies suggest placental mechanistic…”
Get full text

Pancreatic β-Cell O-GlcNAc Transferase Overexpression Increases Susceptibility to Metabolic Stressors in Female Mice by Mohan, Ramkumar, Jo, Seokwon, Da Sol Chung, Elina, Oribamise, Eunice, Lockridge, Amber, Abrahante-Lloréns, Juan E, Ruan, Hai-Bin, Yang, Xiao-Yong, Alejandro, Emilyn U

“…The nutrient-sensor O-GlcNAc transferase (Ogt), the sole enzyme that adds an O-GlcNAc-modification onto proteins, plays a critical role for pancreatic β-cell…”
Get full text

A rare case of MGRS with immunotactoid glomerulopathy responding to bortezomib, dexamethasone, and rituximab by Kuang, Chaoyuan, Quann, Kevin, Liman, Agnes K., Frye, Roy, Alshoubaki, Nawras, Ramkumar, Mohan, Liman, Andrew D.

“…Patients with monoclonal gammopathy of renal significance should be treated with clone‐directed therapy against sources of monoclonal proteins in order to…”
Get full text

SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53 by Kim, Duk Hoon, Jung, Yu Jin, Lee, Jung Eun, Lee, Ae Sin, Kang, Kyung Pyo, Lee, Sik, Park, Sung Kwang, Han, Myung Kwan, Lee, Sang Yong, Ramkumar, Kunga Mohan, Sung, Mi Jeong, Kim, Won

“…Nephrotoxicity is one of the important dose-limiting factors during cisplatin treatment. There is a growing body of evidence that activation of p53 has a…”
Get more information

Oxidative stress-mediated cytotoxicity and apoptosis induction by TiO2 nanofibers in HeLa cells by Ramkumar, Kunga Mohan, Manjula, Chinnasamy, GnanaKumar, Georgepeter, Kanjwal, Muzafar A., Sekar, Thillai V., Paulmurugan, Ramasamy, Rajaguru, Palanisamy

“…Exposure of human cervical adenocarcinoma HeLa cells to titanium dioxide nanofibers resulting its uptake and the following induction of oxidative-stress…”
Get full text

Antidiabetic activity of alcoholic stem extract of Gymnema montanum in streptozotocin-induced diabetic rats by Ramkumar, Kunga Mohan, Vanitha, Pachamuthu, Uma, Chidambaram, Suganya, Natarajan, Bhakkiyalakshmi, Elango, Sujatha, Jaiganesh

“…► Gymnema montanum stem in type-1 diabetes. ► Significant increase in insulin in diabetes. ► Modulation of carbohydrate enzymes. In the present study, the…”
Get full text

Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects by Woda, Craig B, Miyawaki, Nobuyuki, Ramalakshmi, Santhanam, Ramkumar, Mohan, Rojas, Raul, Zavilowitz, Beth, Kleyman, Thomas R, Satlin, Lisa M

“…High urinary flow rates stimulate K secretion in the fully differentiated but not neonatal or weanling rabbit cortical collecting duct (CCD). Both…”
Get more information

A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects by Kleinhans, Claudia, Mohan, Ramkumar Ramani, Vacun, Gabriele, Schwarz, Thomas, Haller, Barbara, Sun, Yang, Kahlig, Alexander, Kluger, Petra, Finne-Wistrand, Anna, Walles, Heike, Hansmann, Jan

“…Critical size bone defects and non‐union fractions are still challenging to treat. Cell‐loaded bone substitutes have shown improved bone ingrowth and bone…”
Get full text

Potential in vitro antioxidant and protective effects of Gymnema montanum H. on alloxan-induced oxidative damage in pancreatic β-cells, HIT-T15 by Ramkumar, Kunga Mohan, Manjula, Chinnasamy, Sankar, Lakshmanan, Suriyanarayanan, Sarvajayakesavalu, Rajaguru, Palanisamy

“…The present study describes the antioxidant activities of ethanol extract from Gymnema montanum (GLEt) which is an endemic plant of India. Antioxidant activity…”
Get full text