Search Results - "Mohan, Maradumane L."

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors by Nemet, Ina, Saha, Prasenjit Prasad, Gupta, Nilaksh, Zhu, Weifei, Romano, Kymberleigh A., Skye, Sarah M., Cajka, Tomas, Mohan, Maradumane L., Li, Lin, Wu, Yuping, Funabashi, Masanori, Ramer-Tait, Amanda E., Naga Prasad, Sathyamangla Venkata, Fiehn, Oliver, Rey, Federico E., Tang, W.H. Wilson, Fischbach, Michael A., DiDonato, Joseph A., Hazen, Stanley L.

“…Using untargeted metabolomics (n = 1,162 subjects), the plasma metabolite (m/z = 265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an…”
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Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB–mediated mechanism by Qiu, Jia, Thapaliya, Samjhana, Runkana, Ashok, Yu Yang, Tsien, Cynthia, Mohan, Maradumane L., Narayanan, Arvind, Eghtesad, Bijan, Mozdziak, Paul E., McDonald, Christine, Stark, George R., Welle, Stephen, Prasad, Sathyamangla V. Naga, Dasarathy, Srinivasan

“…Loss of muscle mass, or sarcopenia, is nearly universal in cirrhosis and adversely affects patient outcome. The underlying cross-talk between the liver and…”
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Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors by Saha, Prasenjit Prasad, Gogonea, Valentin, Sweet, Wendy, Mohan, Maradumane L., Singh, Khuraijam Dhanachandra, Anderson, James T., Mallela, Deepthi, Witherow, Conner, Kar, Niladri, Stenson, Kate, Harford, Terri, Fischbach, Michael A., Brown, J. Mark, Karnik, Sadashiva S., Moravec, Christine S., DiDonato, Joseph A., Naga Prasad, Sathyamangla Venkata, Hazen, Stanley L.

“…Allosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine…”
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Inhibition of Protein Phosphatase 2A Activity by PI3Kγ Regulates β-Adrenergic Receptor Function by Vasudevan, Neelakantan T., Mohan, Maradumane L., Gupta, Manveen K., Hussain, Afshan K., Naga Prasad, Sathyamangla V.

“…Phosphoinositide 3-kinase γ (PI3Kγ) is activated by G protein-coupled receptors (GPCRs). We show here that PI3Kγ inhibits protein phosphatase 2A (PP2A) at the…”
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Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling by Gupta, Manveen K., Sahu, Anita, Sun, Yu, Mohan, Maradumane L., Kumar, Avinash, Zalavadia, Ajaykumar, Wang, Xi, Martelli, Elizabeth E., Stenson, Kate, Witherow, Conner P., Drazba, Judy, Dasarathy, Srinivasan, Naga Prasad, Sathyamangla V.

“…Although microRNA-7 (miRNA-7) is known to regulate proliferation of cancer cells by targeting Epidermal growth factor receptor (EGFR/ERBB) family, less is…”
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Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation by Watson, Lewis J, Alexander, Kevin M, Mohan, Maradumane L, Bowman, Amber L, Mangmool, Supachoke, Xiao, Kunhong, Naga Prasad, Sathyamangla V, Rockman, Howard A

“…β2-Adrenergic receptors (β2AR) transactivate epidermal growth factor receptors (EGFR) through formation of a β2AR-EGFR complex that requires activation of Src…”
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Abnormal brain iron homeostasis in human and animal prion disorders by Singh, Ajay, Isaac, Alfred Orina, Luo, Xiu, Mohan, Maradumane L, Cohen, Mark L, Chen, Fusong, Kong, Qingzhong, Bartz, Jason, Singh, Neena

“…Neurotoxicity in all prion disorders is believed to result from the accumulation of PrP-scrapie (PrP(Sc)), a beta-sheet rich isoform of a normal cell-surface…”
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Regulation of β-adrenergic receptor function: An emphasis on receptor resensitization by Vasudevan, Neelakantan T., Mohan, Maradumane L., Goswami, Shyamal K., Prasad, Sathyamangla V. Naga

“…G protein-coupled receptors are the largest family of cell surface receptors regulating multiple cellular processes. β-adrenergic receptor (βAR) is a…”
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Prion protein modulates cellular iron uptake: a novel function with implications for prion disease pathogenesis by Singh, Ajay, Mohan, Maradumane L, Isaac, Alfred Orina, Luo, Xiu, Petrak, Jiri, Vyoral, Daniel, Singh, Neena

“…Converging evidence leaves little doubt that a change in the conformation of prion protein (PrP(C)) from a mainly alpha-helical to a beta-sheet rich…”
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Phosphoinositide Binding Differentially Regulates NHE1 Na+/H+ Exchanger-dependent Proximal Tubule Cell Survival by Abu Jawdeh, Bassam G., Khan, Shenaz, Deschênes, Isabelle, Hoshi, Malcolm, Goel, Monu, Lock, Jeffrey T., Shinlapawittayatorn, Krekwit, Babcock, Gerald, Lakhe-Reddy, Sujata, DeCaro, Garren, Yadav, Satya P., Mohan, Maradumane L., Naga Prasad, Sathyamangla V., Schilling, William P., Ficker, Eckhard, Schelling, Jeffrey R.

“…Tubular atrophy predicts chronic kidney disease progression, and is caused by proximal tubular epithelial cell (PTC) apoptosis. The normally quiescent Na+/H+…”
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Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ by Sun, Yu, Stenson, Kate, Mohan, Maradumane L., Gupta, Manveen K., Wanner, Nick, Asosingh, Kewal, Erzurum, Serpil, Naga Prasad, Sathyamangla V.

“…Impaired beta-adrenergic receptor (β1 and β2AR) function following hypoxia underlies ischemic heart failure/stroke. Activation of PI3Kγ (phosphoinositide…”
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Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate–Activated Protein Kinase, Causing Sarcopenia in Alcohol‐Associated Liver Disease by Davuluri, Gangarao, Welch, Nicole, Sekar, Jinendiran, Gangadhariah, Mahesha, Alsabbagh Alchirazi, Khaled, Mohan, Maradumane L., Kumar, Avinash, Kant, Sashi, Thapaliya, Samjhana, Stine, McKenzie, McMullen, Megan R., McCullough, Rebecca L., Stark, George R., Nagy, Laura E., Naga Prasad, Sathyamangla V., Dasarathy, Srinivasan

“…Background and Aims Despite the high clinical significance of sarcopenia in alcohol‐associated cirrhosis, there are currently no effective therapies because…”
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Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure by Romano, Kymberleigh A., Nemet, Ina, Prasad Saha, Prasenjit, Haghikia, Arash, Li, Xinmin S., Mohan, Maradumane L., Lovano, Beth, Castel, Laurie, Witkowski, Marco, Buffa, Jennifer A., Sun, Yu, Li, Lin, Menge, Christopher M., Demuth, Ilja, König, Maximilian, Steinhagen-Thiessen, Elisabeth, DiDonato, Joseph A., Deb, Arjun, Bäckhed, Fredrik, Tang, W.H. Wilson, Naga Prasad, Sathyamangla Venkata, Landmesser, Ulf, Van Wagoner, David R., Hazen, Stanley L.

“…The gut microbiota-dependent metabolite phenylacetylgutamine (PAGln) is both associated with atherothrombotic heart disease in humans, and mechanistically…”
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G Protein-Coupled Receptor Resensitization Paradigms by Gupta, Manveen K, Mohan, Maradumane L, Naga Prasad, Sathyamangla V

“…Cellular responses to extracellular milieu/environment are driven by cell surface receptors that transmit the signal into the cells resulting in a synchronized…”
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The IgG3 subclass of β1-adrenergic receptor autoantibodies is an endogenous biaser of β1AR signaling by Mohan, Maradumane L, Nagatomo, Yuji, Saha, Prasenjit Prasad, Mukherjee, Sromona D, Engelman, Timothy, Morales, Rommel, Hazen, Stanley L, Tang, W H Wilson, Naga Prasad, Sathyamangla V

“…Dysregulation of immune responses has been linked to the generation of immunoglobulin G (IgG) autoantibodies that target human β1ARs and contribute to…”
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G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation by Tirupula, Kalyan C, Ithychanda, Sujay S, Mohan, Maradumane L, Naga Prasad, Sathyamangla V, Qin, Jun, Karnik, Sadashiva S

“…Although interaction of a few G protein-coupled receptors (GPCRs) with Filamin A, a key actin cross-linking and biomechanical signal transducer protein, has…”
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Scaffolding Function of PI3Kgamma Emerges from Enzyme's Shadow by Mohan, Maradumane L, Naga Prasad, Sathyamangla V

“…Traditionally, an enzyme is a protein that mediates biochemical action by binding to the substrate and by catalyzing the reaction that translates external cues…”
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Proinflammatory Cytokines Mediate GPCR Dysfunction by Mohan, Maradumane L, Vasudevan, Neelakantan T, Naga Prasad, Sathyamangla V

“…Proinflammatory reaction by the body occurs acutely in response to injury that is considered primarily beneficial. However, sustained proinflammatory cytokines…”
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Noncanonical regulation of insulin-mediated ERK activation by phosphoinositide 3-kinase γ by Mohan, Maradumane L, Chatterjee, Arunachal, Ganapathy, Swetha, Mukherjee, Sromona, Srikanthan, Sowmya, Jolly, George P, Anand, Rohit S, Naga Prasad, Sathyamangla V

“…Classically Class IB phosphoinositide 3-kinase (PI3Kγ) plays a role in extracellular signal-regulated kinase (ERK) activation following G-protein coupled…”
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Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesis by Basu, Subhabrata, Mohan, Maradumane L, Luo, Xiu, Kundu, Bishwajit, Kong, Qingzhong, Singh, Neena

“…The principal infectious and pathogenic agent in all prion disorders is a beta-sheet-rich isoform of the cellular prion protein (PrP(C)) termed PrP-scrapie…”
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