Search Results - "Mohan, Dipika R"

Targeting Oncogenic Wnt/β-Catenin Signaling in Adrenocortical Carcinoma Disrupts ECM Expression and Impairs Tumor Growth by Penny, Morgan K, Lerario, Antonio M, Basham, Kaitlin J, Chukkapalli, Sahiti, Mohan, Dipika R, LaPensee, Chris, Converso-Baran, Kimber, Hoenerhoff, Mark J, Suárez-Fernández, Laura, Rey, Carmen González Del, Giordano, Thomas J, Han, Ruolan, Newman, Erika A, Hammer, Gary D

“…Adrenocortical carcinoma (ACC) is a rare but highly aggressive cancer with limited treatment options and poor survival for patients with advanced disease. An…”
Get full text

SELAdb: A database of exonic variants in a Brazilian population referred to a quaternary medical center in São Paulo by Lerario, Antonio Marcondes, Mohan, Dipika R., Montenegro, Luciana Ribeiro, Funari, Mariana Ferreira de Assis, Nishi, Mirian Yumie, Narcizo, Amanda de Moraes, Benedetti, Anna Flavia Figueredo, Oba-Shinjo, Sueli Mieko, Vitorino, Aurélio José, Santos, Rogério Alexandre Scripnic Xavier dos, Jorge, Alexander Augusto de Lima, Onuchic, Luiz Fernando, Marie, Suely Kazue Nagahashi, Mendonca, Berenice Bilharinho

“…High-throughput sequencing of genomes, exomes, and disease-focused gene panels is becoming increasingly common for molecular diagnostics. However, identifying…”
Get full text

Closing the loop on adrenal health, dysfunction, and disease by Mohan, Dipika R, Lerario, Antonio Marcondes

“…A wearable microdialysis device measures ultradian patterns of adrenal hormone secretion in humans at minute scale (Upton .)…”
Get more information

Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies by Lerario, Antonio Marcondes, Mohan, Dipika R, Hammer, Gary D

“…Abstract The adrenal glands are paired endocrine organs that produce steroid hormones and catecholamines required for life. Adrenocortical carcinoma (ACC) is a…”
Get full text

Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma by Mohan, Dipika R, Lerario, Antonio Marcondes, Else, Tobias, Mukherjee, Bhramar, Almeida, Madson Q, Vinco, Michelle, Rege, Juilee, Mariani, Beatriz M P, Zerbini, Maria Claudia N, Mendonca, Berenice B, Latronico, Ana Claudia, Marie, Suely K N, Rainey, William E, Giordano, Thomas J, Fragoso, Maria Candida B V, Hammer, Gary D

“…Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with few therapies; however, patients with locoregional disease have variable outcomes. The…”
Get full text

Therapeutic Targets for Adrenocortical Carcinoma in the Genomics Era by Mohan, Dipika R, Lerario, Antonio Marcondes, Hammer, Gary D

“…Abstract Adrenocortical carcinoma (ACC) is a rare and often fatal cancer, affecting ~1 person per million per year worldwide. Approximately 75% of patients…”
Get full text

Somatic Activating ESR1 Mutation in an Aggressive Prolactinoma by Paes, Ticiana, Buelvas Mebarak, Jacobo, Magnotto, John C, Stamatiades, George A, Kuang, Yanan, Paweletz, Cloud, Laws, Edward R, Grosek, Natalie, Carroll, Rona S, Jeselsohn, Rinath, Mohan, Dipika R, Lerario, Antonio Marcondes, Truong, Minh T, Bi, Wenya Linda, Reardon, David A, Meredith, David M, Kaiser, Ursula B, Abreu, Ana Paula

“…The genetic profile of prolactinomas remains poorly understood. Our objective is to identify somatic genetic alterations associated with prolactinomas and to…”
Get full text

Impact of a cell cycle and an extracellular matrix remodeling transcriptional signature on tumor progression and correlation with EZH2 expression in meningioma by Pereira, Benedito Jamilson Araújo, Marcondes Lerario, Antonio, Sola, Paula Rodrigues, Laurentino, Talita de Sousa, Mohan, Dipika R, de Almeida, Antonio Nogueira, Pires de Aguiar, Paulo Henrique, da Silva Paiva, Wellingson, Wakamatsu, Alda, Teixeira, Manoel Jacobsen, Oba-Shinjo, Sueli Mieko, Marie, Suely Kazue Nagahashi

“…The authors searched for genetic and transcriptional signatures associated with tumor progression and recurrence in their cohort of patients with meningiomas,…”
Get full text

β-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer by Mohan, Dipika R, Borges, Kleiton S, Finco, Isabella, LaPensee, Christopher R, Rege, Juilee, Solon, April L, Little, Donald W, Else, Tobias, Almeida, Madson Q, Dang, Derek, Haggerty-Skeans, James, Apfelbaum, April A, Vinco, Michelle, Wakamatsu, Alda, Mariani, Beatriz M P, Amorim, Larissa Costa, Latronico, Ana Claudia, Mendonca, Berenice B, Zerbini, Maria Claudia N, Lawlor, Elizabeth R, Ohi, Ryoma, Auchus, Richard J, Rainey, William E, Marie, Suely K N, Giordano, Thomas J, Venneti, Sriram, Fragoso, Maria Candida Barisson Villares, Breault, David T, Lerario, Antonio Marcondes, Hammer, Gary D

“…Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation is paradoxically associated with dismal outcomes. The differentiated…”
Get full text

Regulation of stem and progenitor cells in the adrenal cortex by Finco, Isabella, Mohan, Dipika R, Hammer, Gary D, Lerario, Antonio Marcondes

“…The adrenal cortex is an endocrine organ comprised of three histological zones, the outermost zona glomerulosa, the intermediate zona fasciculata, and the…”
Get full text

New strategies for applying targeted therapies to adrenocortical carcinoma by Mohan, Dipika R, Lerario, Antonio Marcondes, Finco, Isabella, Hammer, Gary D

“…Adrenocortical carcinoma (ACC) is a rare, aggressive, and frequently deadly cancer. Up to 75% of all patients will eventually develop metastatic disease, and…”
Get full text

Aberrant Epigenetic Patterning Defines an Aggressive Molecular Subtype of Adrenocortical Carcinoma and Exposes a Tissue-Specific Therapeutic Vulnerability by Mohan, Dipika R

“…The adrenal glands are endocrine organs that produce steroid hormones and catecholamines critical for life. Adrenocortical carcinoma (ACC) is a rare cancer of…”
Get full text

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing by Okeyo-Owuor, T, White, B S, Chatrikhi, R, Mohan, D R, Kim, S, Griffith, M, Ding, L, Ketkar-Kulkarni, S, Hundal, J, Laird, K M, Kielkopf, C L, Ley, T J, Walter, M J, Graubert, T A

“…We previously identified missense mutations in the U2AF1 splicing factor affecting codons S34 (S34F and S34Y) or Q157 (Q157R and Q157P) in 11% of the patients…”
Get full text

OR20-04 Genetic Profiling Using A Gene Panel Identifies Pathogenic Variants And Copy Number Variations In Pituitary Adenomas by Silva, Ticiana, Mohan, Dipika R, Mebarak, Jacobo Buelvas, Meredith, David, Bi, Wenya L, Carroll, Rona Stephanie, Kaiser, Ursula B, Lerario, Antonio Marcondes, Abreu, Ana Paula

“…Disclosure: T. Silva: None. D. Mohan: None. J. Mebarak: None. D. Meredith: None. W. Bi: Speaker; Self; Stryker. R. Carroll: None. U.B. Kaiser: None. A…”
Get full text

7826 The Identification of an Activating ESR1 Mutation in an Aggressive Prolactinoma Enabled the Use of Personalized Treatment by Paes, Ticiana, Mebarak, Jacobo Buelvas, Magnotto, John C, Stamatiades, George A, Kuang, Yanan, Paweletz, Cloud, Laws, Edward Raymond, Carroll, Rona Stephanie, Jeselsohn, Rinath, Mohan, Dipika R, Lerario, Antonio Marcondes, Bi, Wenya L, Reardon, David A, Meredith, David M, Kaiser, Ursula B, Abreu, Ana Paula

“…Disclosure: T. Paes: None. J.B. Mebarak: None. J. C. Magnotto: None. G. A. Stamatiades: None. Y. Kuang: None. C. Paweletz: None. E.R. Laws: None. R.S. Carroll:…”
Get full text

Abstract 1501: Epigenetic dedifferentiation as a therapeutic strategy in adrenal cancer by Mohan, Dipika R., Borges, Kleiton S., Finco, Isabella, LaPensee, Christopher R., Rege, Juilee, Little, Donald W., Else, Tobias, Almeida, Madson Q., Dang, Derek, Haggerty-Skeans, James, Latronico, Ana Claudia, Mendonca, Berenice B., Auchus, Richard J., Rainey, William E., Marie, Suely K., Giordano, Thomas J., Venneti, Sriram, Fragoso, Maria Candida B., Breault, David T., Lerario, Antonio M., Hammer, Gary D.

“…Adrenocortical carcinoma (ACC) is a rare cancer of the adrenal cortex without curative medical therapies. CIMP-high is an aggressive ACC molecular subtype…”
Get full text

SAT-LB34 Repressive Epigenetic Programs Reinforce Steroidogenic Differentiation and Wnt/β-Catenin Signaling in Aggressive Adrenocortical Carcinoma by Mohan, Dipika R, Finco, Isabella, LaPensee, Christopher Ryan, Rege, Juilee, Else, Tobias, Almeida, Madson Q, Vinco, Michelle, Wakamatsu, Alda, Latronico, Ana Claudia, Mendonca, Berenice Bilharinho, Zerbini, Maria Claudia N, Fragoso, Maria Candida Barisson Villares, Rainey, William E, Venneti, Sriram, Marie, Suely K N, Giordano, Thomas J, Lerario, Antonio Marcondes, Hammer, Gary D

“…Adrenocortical carcinoma (ACC) is a rare, aggressive cancer. Up to 75% of patients develop incurable metastatic disease, highlighting an urgent need for novel…”
Get full text