Search Results - "Mohammed, Yassene"
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Determination of the concentration range for 267 proteins from 21 lots of commercial human plasma using highly multiplexed multiple reaction monitoring mass spectrometry
Published in Analyst (London) (18-05-2020)“…Multiple reaction monitoring (MRM) is a key tool for biomarker validation and the translation of potential biomarkers into the clinic. To demonstrate the…”
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Visualization and application of amino acid retention coefficients obtained from modeling of peptide retention
Published in Journal of separation science (01-09-2018)“…We introduce a method for data inspection in liquid separations of peptides using amino acid retention coefficients and their relative change across…”
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Visualizing and comparing results of different peptide identification methods
Published in Briefings in bioinformatics (01-03-2018)“…Abstract In mass spectrometry-based proteomics, peptides are typically identified from tandem mass spectra using spectrum comparison. A sequence search engine…”
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Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution
Published in Proceedings of the National Academy of Sciences - PNAS (08-10-2019)“…Targeting metabolism through bioactive key metabolites is an upcoming future therapeutic strategy. We questioned how modifying intracellular lipid metabolism…”
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Mouse Quantitative Proteomics Knowledgebase: reference protein concentration ranges in 20 mouse tissues using 5000 quantitative proteomics assays
Published in Bioinformatics (Oxford, England) (27-07-2021)“…Abstract MotivationLaboratory mouse is the most used animal model in biological research, largely due to its high conserved synteny with human. Researchers…”
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Evaluation of Fast and Sensitive Proteome Profiling of FF and FFPE Kidney Patient Tissues
Published in Molecules (Basel, Switzerland) (08-02-2022)“…The application of proteomics to fresh frozen (FF) and formalin-fixed paraffin-embedded (FFPE) human tissues is an important development spurred on by requests…”
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Concentration Determination of >200 Proteins in Dried Blood Spots for Biomarker Discovery and Validation
Published in Molecular & cellular proteomics (01-03-2020)“…Multiple reaction monitoring with isotope dilution assays were developed for quantification of 200 proteins in dried blood spots, with median inter-day CV of…”
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ExSTA: External Standard Addition Method for Accurate High‐Throughput Quantitation in Targeted Proteomics Experiments
Published in Proteomics. Clinical applications (01-03-2018)“…Purpose Targeted proteomics using MRM with stable‐isotope‐labeled internal‐standard (SIS) peptides is the current method of choice for protein quantitation in…”
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The intestinal microbiome potentially affects thrombin generation in human subjects
Published in Journal of thrombosis and haemostasis (01-03-2020)“…Background The intestinal microbiome plays a versatile role in the etiology of arterial thrombosis. In venous thrombosis, driven chiefly by plasma coagulation,…”
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Targeted proteomics for evaluating risk of venous thrombosis following traumatic lower‐leg injury or knee arthroscopy
Published in Journal of thrombosis and haemostasis (01-03-2022)“…Introduction Patients with lower‐leg cast immobilization and patients undergoing knee arthroscopy have an increased risk of venous thrombosis (VT). Guidelines…”
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Fatty acid desaturation and lipoxygenase pathways support trained immunity
Published in Nature communications (15-11-2023)“…Infections and vaccines can induce enhanced long-term responses in innate immune cells, establishing an innate immunological memory termed trained immunity …”
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Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation
Published in EMBO molecular medicine (07-08-2023)“…Liver X receptor (LXR) agonism has theoretical potential for treating NAFLD/NASH, but synthetic agonists induce hyperlipidemia in preclinical models…”
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Multiplexed panel of precisely quantified salivary proteins for biomarker assessment
Published in Proteomics (Weinheim) (01-03-2017)“…An increasingly popular “absolute” quantitative technique involves the SRM or MRM approach with stable isotope‐labeled standards (SIS). Using this approach,…”
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N -Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity
Published in International journal of molecular sciences (01-08-2020)“…Colorectal cancer (CRC) is the second-leading cause of cancer death worldwide due in part to a high proportion of patients diagnosed at advanced stages of the…”
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Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2)
Published in International journal of molecular sciences (20-05-2021)“…Developments in mass spectrometry (MS)-based analyses of glycoproteins have been important to study changes in glycosylation related to disease. Recently, the…”
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Congruence and Complementarity of Differential Mobility Spectrometry and NMR Spectroscopy for Plasma Lipidomics
Published in Metabolites (27-10-2022)“…The lipid composition of lipoprotein particles is determinative of their respective formation and function. In turn, the combination and correlation of nuclear…”
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A standardized kit for automated quantitative assessment of candidate protein biomarkers in human plasma
Published in Bioanalysis (01-12-2015)“…An increasingly popular mass spectrometry-based quantitative approach for health-related research in the biomedical field involves the use of stable…”
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Clostridioides difficile Phosphoproteomics Shows an Expansion of Phosphorylated Proteins in Stationary Growth Phase
Published in mSphere (23-02-2022)“…Phosphorylation is a posttranslational modification that can affect both housekeeping functions and virulence characteristics in bacterial pathogens. In the…”
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Spatially and temporally resolved metabolome of the human oral cavity
Published in iScience (16-02-2024)“…Saliva is a complex bodily fluid composed of secretions by major and minor salivary glands. Salivary glands and their secretions are known to be unevenly…”
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Systematic Optimization of the iMALDI Workflow for the Robust and Straightforward Quantification of Signaling Proteins in Cancer Cells
Published in Proteomics. Clinical applications (01-09-2020)“…Purpose Immuno‐MALDI (iMALDI) combines immuno‐enrichment of biomarkers with MALDI‐MS for fast, precise, and specific quantitation, making it a valuable tool…”
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