Prevalence of HCV coinfection in HIV-infected individuals in Nigeria and characterization of HCV genotypes

Coinfection with hepatitis C virus (HCV) in individuals infected with HIV is associated with a higher incidence of liver injury, hepatic decompensation, and decreased survival time than that seen in an HIV-monoinfected population. While prevalence studies on HIV/HCV coinfection have been performed i...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of clinical virology Vol. 31; no. S1; pp. 3 - 6
Main Authors:	Agwale, Simon M., Tanimoto, Lorine, Womack, Chad, Odama, Lillian, Leung, Kimmy, Duey, Dolores, Negedu-Momoh, Ruth, Audu, Israel, Mohammed, Shehu B., Inyang, Uford, Graham, Barney, Ziermann, Rainer
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-12-2004 Elsevier Science
Subjects:	Adult Biological and medical sciences CD4 Lymphocyte Count Epidemiology Female Fundamental and applied biological sciences. Psychology Genotype HCV HCV genotypes Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis C - blood Hepatitis C - complications Hepatitis C - virology Hepatitis C virus HIV HIV Infections - blood HIV Infections - complications HIV Infections - virology HIV Seropositivity - immunology HIV/HCV coinfection Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Nigeria - epidemiology Prevalence Retrospective Studies RNA, Viral - analysis VERSANT ® HCV genotyping assay (LiPA) VERSANT ® HCV qualitative assay (TMA) Viral diseases Virology Nigeria Africa HCV genotypes HCV HIV/HCV coinfection HIV VERSANT ® HCV qualitative assay (TMA) VERSANT ® HCV genotyping assay (LiPA) Mixed infection Prevalence Microbiology Epidemiology Characterization Human Immunopathology Typing Retroviridae Genotype AIDS Immune deficiency Lentivirus VERSANT® HCV qualitative assay (TMA) Virology Infection Virus VERSANT® HCV genotyping assay (LiPA) Viral disease Human immunodeficiency virus Flaviviridae Hepatitis C virus Hepacivirus
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Coinfection with hepatitis C virus (HCV) in individuals infected with HIV is associated with a higher incidence of liver injury, hepatic decompensation, and decreased survival time than that seen in an HIV-monoinfected population. While prevalence studies on HIV/HCV coinfection have been performed in the U.S. and in some European countries, little is known about coinfection rates in Africa. Retrospectively collected specimens from 146 confirmed HIV-positive individuals in Nigeria who had access to antiretroviral therapy (ART) were tested for HCV RNA, using the VERSANT ® HCV RNA qualitative assay (TMA), and, if HCV RNA-positive, for HCV genotype using the VERSANT ® HCV genotype assay (LiPA). Twelve out of the 146 individuals tested (8.2%) were HCV positive. Nine of the 12 HCV-positive individuals were infected with HCV genotype 1 (five 1a, three 1b, one non-subtypable) and three were infected with HCV genotype 2 (all non-subtypable). Coinfected individuals were more likely to be male, older, and have lower CD4+ cell counts than HIV-monoinfected individuals, although none of the differences reached statistical significance. The results highlight the potential public health impact of HCV infection in Nigeria, where anti-HCV testing is generally not performed in HIV-infected populations or in most blood transfusion centers.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2004.09.001