Nephroprotective effects of Acacia senegal against aflatoxicosis via targeting inflammatory and apoptotic signaling pathways

Nephroprotective effects of Acacia senegal against aflatoxicosis via targeting inflammatory and apoptotic signaling pathways

Aflatoxin B1 (AFB1) is a common environmental pollutant that poses a major hazard to both humans and animals. Acacia senegal (Gum) is well-known for having antioxidant and anti-inflammatory bioactive compounds. Our study aimed to scout the nephroprotective effects of Acacia gum (Gum) against AFB1-in...

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Published in:Ecotoxicology and environmental safety Vol. 262; p. 115194
Main Authors: Shanab, Obeid, El-Rayes, Samir M., Khalil, Waleed F., Ahmed, Noha, Abdelkader, Afaf, Aborayah, Nashwa H., Atwa, Ahmed M., Mohammed, Faten I., Nasr, Hend E., Ibrahim, Samah F., Khattab, Amr M., Alsieni, Mohammed, Behairy, Ali, Fericean, Liana, Mohammed, Lina A., Abdeen, Ahmed
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01-09-2023
Elsevier
Subjects:
Apoptosis
GC/MS
Mycotoxins
Nutraceuticals
Oxidative stress
Proinflammatory cytokines
Cyto c
Oxidative stress
ALP
AFB1
AFBO
Cl. Casp3–17/19
IL-6
SOD1
NF-κB/P65
TNF-α
Nrf2
ROS
Mycotoxins
iNOS
Proinflammatory cytokines
GSH
Gum
GC/MS
Apoptosis
Nutraceuticals
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Summary:Aflatoxin B1 (AFB1) is a common environmental pollutant that poses a major hazard to both humans and animals. Acacia senegal (Gum) is well-known for having antioxidant and anti-inflammatory bioactive compounds. Our study aimed to scout the nephroprotective effects of Acacia gum (Gum) against AFB1-induced renal damage. Four groups of rats were designed: Control, Gum (7.5 mg/kg), AFB1 (200 µg/kg b.w) and AFB1-Gum, rats were co-treated with both Gum and AFB1. Gas chromatography-mass spectrometry (GC/MS) analysis was done to determine the phytochemical constituents in Gum. AFB1 triggered profound alterations in kidney function parameters (urea, creatinine, uric acid, and alkaline phosphatase) and renal histological architecture. Additionally, AFB1 exposure evoked up-regulation of mRNA expression levels of inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor α (TNFα), inducible nitric oxide synthase (iNOS), and nuclear factor kB p65 (NF-κB/P65) in renal tissue. The oxidative distress and apoptotic cascade are also instigated by AFB1 intoxication as depicted in down-regulated protein expression of the nuclear factor erythroid 2–related factor 2 (Nrf2) and superoxide dismutase type 1 (SOD1) along with upregulation of cytochrome c (Cyto c), and cleaved Caspase3 (Casp3–17 and 19) in renal tissue. In conclusion, current study obviously confirms the alleviating effects of Gum supplementation against AFB1-induced renal dysfunction, oxidative harm, inflammation, and cell death. These mitigating effects are suggested to be attributed to Gum's antioxidant and anti-inflammatory activities. Our results recommend Gum supplementation as add-on agents to food that might aid in protection from AFB1-induced nephrotoxicity. •Aflatoxin B1- provoked renal damage via oxidative stress and inflammatory pathways.•Acacia senegal (Gum) ameliorates AFB1-induced renal damage.•Gum inhibits oxidative stress and inflammation in the AFB1-induced renal damage.•Gum reduces AFB1-induced apoptosis in rats’ kidney.•Gum supplementation has therapeutic potential against AFB1-induced renal damage.
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content type line 23
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2023.115194