Turmeric Extract Rescues Ethanol‐Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD)

Turmeric Extract Rescues Ethanol‐Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD)

Prenatal ethanol exposure causes the most frequent preventable birth disorder, fetal alcohol spectrum disorder (FASD). The effect of turmeric extracts in rescuing an ethanol‐induced developmental defect using zebrafish as a model was determined. Ethanol‐induced oxidative stress is one of the major m...

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Bibliographic Details
Published in:Journal of food science Vol. 82; no. 9; pp. 2221 - 2225
Main Authors: Muralidharan, Pooja, Connors, Craig T., Mohammed, Arooj S., Sarmah, Swapnalee, Marrs, Kathleen, Marrs, James A., Chism, Grady W.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-09-2017
Subjects:
Alcohols
Animals
Antioxidants
Body length
Curcuma - anatomy & histology
Curcuma - chemistry
Curcumin
Defects
Dietary Supplements - analysis
Disabilities
Disease Models, Animal
Embryo, Nonmammalian
Embryos
Ethanol
Ethanol - toxicity
ethanol‐induced defects
Exposure
Female
fetal alcohol spectrum disorder
Fetal Alcohol Spectrum Disorders - physiopathology
Fetal Alcohol Spectrum Disorders - prevention & control
Fetal alcohol syndrome
Gastrulation
Humans
Infants
Male
nutritional supplement
Organogenesis
Oxidative stress
Plant Extracts - administration & dosage
Plant Extracts - analysis
Powder
Prenatal experience
Supplements
turmeric
Zebrafish
Zebrafish - growth & development
fetal alcohol spectrum disorder
turmeric
zebrafish
ethanol-induced defects
nutritional supplement
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Summary:Prenatal ethanol exposure causes the most frequent preventable birth disorder, fetal alcohol spectrum disorder (FASD). The effect of turmeric extracts in rescuing an ethanol‐induced developmental defect using zebrafish as a model was determined. Ethanol‐induced oxidative stress is one of the major mechanisms underlying FASD. We hypothesize that antioxidant inducing properties of turmeric may alleviate ethanol‐induced defects. Curcuminoid content of the turmeric powder extract (5 mg/mL turmeric in ethanol) was determined by UPLC and found to contain Curcumin (124.1 ± 0.2 μg/mL), Desmethoxycurcumin (43.4 ± 0.1 μg/mL), and Bisdemethoxycurcumin (36.6 ± 0.1 μg/mL). Zebrafish embryos were treated with 100 mM (0.6% v/v) ethanol during gastrulation through organogenesis (2 to 48 h postfertilization (hpf)) and supplemented with turmeric extract to obtain total curcuminoid concentrations of 0, 1.16, 1.72, or 2.32 μM. Turmeric supplementation showed significant rescue of the body length at 72 hpf compared to ethanol‐treated embryos. The mechanism underlying the rescue remains to be determined. Practical Application Fetal alcohol spectrum disorder is an umbrella term describing a range of defects caused by prenatal alcohol exposure. FASD prevalence ranges from 0.3% to 5% of the live born infants, and can be as high as 8.9% in low socioeconomic populations. These defects include mental retardation, learning and behavioral disabilities, and growth defects. Identifying the mechanism of the rescue effect of turmeric could lead to potential preventative treatments.
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ISSN:0022-1147
1750-3841
DOI:10.1111/1750-3841.13830