Search Results - "Mohammed, Anber F."

Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways by Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G. M.

“…Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We…”
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Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents by Al-Wahaibi, Lamya H, Mohammed, Anber F, Abdelrahman, Mostafa H, Trembleau, Laurent, Youssif, Bahaa G M

“…A small set of indole-based derivatives, and - , was designed and synthesized. Compounds - demonstrated promising antiproliferative activity, with GI values…”
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Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors by Mahmoud, Mohamed A, Mohammed, Anber F, Salem, Ola I A, Almutairi, Tahani Mazyad, Bräse, Stefan, Youssif, Bahaa G M

“…A novel series of 1,2,3-triazole/1,2,4-oxadiazole hybrids ( - ) was developed as dual inhibitors of EGFR/VEGFR-2. Compounds - were evaluated as…”
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Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors by Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdel Rahman, Fatema El-Zahraa S., Abdelrahman, Mostafa H., Gu, Xuyuan, Trembleau, Laurent, Youssif, Bahaa G. M.

“…A new series of indole-2-carboxamides 5a-g, 6a-f and pyrido[3,4-b]indol-1-ones 7a and 7b have been developed as new antiproliferative agents that target both…”
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New Cytotoxic Natural Products from the Red Sea Sponge Stylissa carteri by Abdelhameed, Reda F A, Habib, Eman S, Eltahawy, Nermeen A, Hassanean, Hashim A, Ibrahim, Amany K, Mohammed, Anber F, Fayez, Shaimaa, Hayallah, Alaa M, Yamada, Koji, Behery, Fathy A, Al-Sanea, Mohammad M, Alzarea, Sami I, Bringmann, Gerhard, Ahmed, Safwat A, Abdelmohsen, Usama Ramadan

“…Bioactivity-guided isolation supported by LC-HRESIMS metabolic profiling led to the isolation of two new compounds, a ceramide, stylissamide A ( ), and a…”
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Design, synthesis and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetohydrazide derivatives with anti-inflammatory-analgesic activities by Mohammed, Anber F., Abdel-Moty, Samia G., Hussein, Mostafa A., Abdel-Alim, Abdel-Alim M.

“…The present work describes the synthesis and evaluation of some new acetohydrazones, 1,3,4-oxadiazoles and 1,2,4-triazoles of 1,2,4-triazolo[1,5- a…”
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Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-Ib/I]indol-3-one Derivatives as Potent Inhibitors of EGFR[sup.T790M]/BRAF[sup.V600E] Pathways by Al-Wahaibi, Lamya H, Mohammed, Anber F, Abdelrahman, Mostafa H, Trembleau, Laurent, Youssif, Bahaa G. M

“…Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We…”
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Click chemistry synthesis, biological evaluation and docking study of some novel 2′-hydroxychalcone-triazole hybrids as potent anti-inflammatory agents by Boshra, Andrew N., Abdu-Allah, Hajjaj H.M., Mohammed, Anber F., Hayallah, Alaa M.

“…[Display omitted] •The efficient synthesis of the privileged intermediate 5-azido-2- hydroxyacetophenone.•The synthesis of 20 new 2′-hydroxychalcone-triazole…”
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New 1,3,4‐oxadiazoles linked with the 1,2,3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase by Mahmoud, Mohamed A., Mohammed, Anber F., Salem, Ola I. A., Gomaa, Hesham A. M., Youssif, Bahaa G. M.

“…A series of 1,3,4‐oxadiazole‐1,2,3‐triazole hybrids bearing different pharmacophoric moieties has been designed and synthesized. Their antiproliferative…”
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Phytochemical investigation, molecular docking studies and DFT calculations on the antidiabetic and cytotoxic activities of Gmelina philippensis CHAM by Sayed, Hanaa M., Ahmed, Amany S., Khallaf, Iman SA, Qayed, Wesam S., Mohammed, Anber F., Farghaly, Hanan S.M., Asem, Ayman

“…Gmelina philippensis CHAM is an ornamental plant that is distributed in South Asia and warm regions of the Mediterranean area. The plant is traditionally…”
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Anti-inflammatory and cytotoxic specialised metabolites from the leaves of Glandularia × hybrida by Mohamed, Nesma M., Ahmed, Mai A.M., Khan, Shabana I., Fronczek, Frank R., Mohammed, Anber F., Ross, Samir A.

“…In our ongoing effort to investigate active specialised metabolites from genus Glandularia, phytochemical studies on the ethanolic extract of…”
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Tetrahydrocarbazoles incorporating 5-arylidene-4-thiazolinones as potential antileukemia and antilymphoma targeting tyrosine kinase and tubulin polymerase enzymes: Design, synthesis, structural, biological and molecular docking studies by Ali, Basma S., Mohammed, Anber F., Kariuki, Benson M., El-Awady, Raafat, H. M. Abdu-Allah, Hajjaj

“…[Display omitted] •New tetrahydrocarbazole derivatives incorporating 5-arylidene-4-thiazolinones were synthesized and their structures were validated by…”
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Neuroprotective effects of rutin against cuprizone-induced multiple sclerosis in mice by Nicola, Mariam A., Attaai, Abdelraheim H., Abdel-Raheem, Mahmoud H., Mohammed, Anber F., Abu-Elhassan, Yasmin F.

“…Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system that injures the myelin sheath, provoking progressive…”
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Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives by Mohammed, Anber F., Andrei, Graciela, Hayallah, Alaa M., Abdel-Moty, Samia G., Snoeck, Robert, Simons, Claire

“…[Display omitted] A series of tricyclic penciclovir (PCV) and hydroxybutylguanine (HBG) derivatives have been prepared with enhanced lipophilicity following an…”
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The inhibition of inducible nitric oxide production in lipopolysaccharide-stimulated rat macrophages and in silico studies by flavonoids from Iris spuria L. rhizomes by Khallaf, Iman S.A., Bayoumi, Soad A.L., Malak, Lourin G., Hussein, Abeer M.R., Mohammed, Anber F., El-Mokhtar, Mohamed A., Farag, Salwa F.

“…Iris is the largest genus in the family Iridaceae. Iris plants are distributed in tropical regions of the world. They are used as ornamentals and traditionally…”
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Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR WT/ EGFR T790M inhibitors by Al-Wahaibi, Lamya H, Mohammed, Anber F, Abdel Rahman, Fatema El-Zahraa S, Abdelrahman, Mostafa H, Gu, Xuyuan, Trembleau, Laurent, Youssif, Bahaa G M

“…A new series of indole-2-carboxamides , and pyrido[3,4-b]indol-1-ones and have been developed as new antiproliferative agents that target both wild and mutant…”
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Design, synthesis, biological evaluation and docking study of some new aryl and heteroaryl thiomannosides as FimH antagonists by Mohammed, Anber F., Othman, Shimaa A., Abou-Ghadir, Ola F., Kotb, Ahmed A., Mostafa, Yaser A., El-Mokhtar, Mohamed A., Abdu-Allah, Hajjaj H.M.

“…[Display omitted] •Thiomannosides having aryl or heteroarylthio as aglycones were designed, synthesized, characterized, and evaluated as FimH…”
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Cytotoxic and anti-diabetic potential, metabolic profiling and insilico studies of Syzygium cumini (L.) Skeels belonging to family Myrtaceae by Eldin Elhawary, Seham Salah, Elmotyam, Amira Kamal Eldin, Alsayed, Doaa Kamel, Zahran, Eman Maher, Fouad, Merivat Ahmed, Sleem, Amany Ameen, Elimam, Hanan, Rashed, Mohamed H, Hayallah, Alaa M, Mohammed, Anber F, Abdelmohsen, Usama Ramadan

“…LC-HR-MS-coupled metabolic profiling of the methanol extracts from different parts of (L.), which was extensively identified DNA fingerprinting, led to…”
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Potential of ( Citrus nobilis Lour × Citrus deliciosa Tenora) metabolites on COVID-19 virus main protease supported by in silico analysis by El-Hawary, Seham S, Issa, Marwa Y, Ebrahim, Hanaa S, Mohammed, Anber F, Hayallah, Alaa M, El-Kadder, Essam M Abd, Sayed, Ahmed M, Abdelmohsen, Usama Ramadan

“…One of the promising therapeutic strategies for corona virus 2019 (COVID-19) is tolook for enzyme inhibitors. COVID-19 virus main protease (M ) plays a vital…”
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Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action by Mohamed, Fatma A. M, Alakilli, Saleha Y. M, El Azab, Eman Fawzy, Baawad, Faris A. M, Shaaban, Esraa Ibrahim A, Alrub, Heba Abu, Hendawy, Omnia, Gomaa, Hesham A. M, Bakr, Adel G, Abdelrahman, Mostafa H, Trembleau, Laurent, Mohammed, Anber F, Youssif, Bahaa G. M

“…A new series of 5-substituted-3-ethylindole-2-carboxamides 5a-k and 6a-c was designed and synthesised in an attempt to develop a dual targeted…”
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