Antifungal Properties of on species: A Systematic Review

Background and purpose Candida infections have increased significantly in the antimicrobial resistance era, and synthetic antifungal drugs have limitations. The present work aimed to review the antifungal properties of Zataria multiflora ( Z. multiflora ) as an herbal remedy. Method PubMed, Scopus,...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of evidence-based integrative medicine Vol. 27
Main Authors:	Ali Malekzadeh Shafaroudi DDS, Nadia Elyassi Gorji DDS, Pegah Nasiri DDS, Javad Javidnia PhD Candidate, Mohammad Ebrahimi Saravi DDS
Format:	Journal Article
Language:	English
Published:	SAGE Publishing 01-11-2022
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Background and purpose Candida infections have increased significantly in the antimicrobial resistance era, and synthetic antifungal drugs have limitations. The present work aimed to review the antifungal properties of Zataria multiflora ( Z. multiflora ) as an herbal remedy. Method PubMed, Scopus, ScienceDirect, Web of Science, SID, Civilica, and Magiran databases were searched for the antifungal activity on in vitro , in vivo , dental biofilm, and clinical studies of Z. multiflora on Candida species. Results Overall, 33 articles evaluated the effect of Z. multiflora on Candida species and classified them into four groups, as follows in vitro (23), dental biofilm (6), in vivo (2), and clinical studies (3). All studies considered Z. multiflora effective in reducing or even inhibiting the growth of Candida species. NoMFC significant differences were seen in the effect of Z. multiflora on susceptible Candida compared to the resistant groups of Candida in the studies. It was also influential in inhibiting C. parapsilosis, C. glabrata, C. krusei, C. kefyer, and C. zeylanoides . Conclusion Considering the side effects and resistance of current antifungal drugs as well as the benefits of using herbal medicines, such as lower cost, less likely to develop drug resistance, the absence of side effects, and toxicity compared with chemical ones , it is possible as a powerful alternative to replace or combine with the current antifungal for Candida infection therapy along with other therapies.
ISSN:	2515-690X
DOI:	10.1177/2515690X221132272