Search Results - "Mohamedali, Azim"

Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome by Kulasekararaj, Austin G., Jiang, Jie, Smith, Alexander E., Mohamedali, Azim M., Mian, Syed, Gandhi, Shreyans, Gaken, Joop, Czepulkowski, Barbara, Marsh, Judith C.W., Mufti, Ghulam J.

“…The distinction between acquired aplastic anemia (AA) and hypocellular myelodysplastic syndrome (hMDS) is often difficult, especially nonsevere AA. We…”
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TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis by Kulasekararaj, Austin G., Smith, Alexander E., Mian, Syed A., Mohamedali, Azim M., Krishnamurthy, Pramila, Lea, Nicholas C., Gäken, Joop, Pennaneach, Coralie, Ireland, Robin, Czepulkowski, Barbara, Pomplun, Sabine, Marsh, Judith C., Mufti, Ghulam J.

“…Summary This study aimed to determine the incidence/prognostic impact of TP53 mutation in 318 myelodysplastic syndrome (MDS) patients, and to correlate the…”
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Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes by Kulasekararaj, Austin G., Mohamedali, Azim M., Mufti, Ghulam J.

“…Summary The advent of novel genomic sequencing technologies has aided the identification of somatically acquired genetic abnormalities up to 80% of…”
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FLT3 and JAK2 Mutations in Acute Myeloid Leukemia Promote Interchromosomal Homologous Recombination and the Potential for Copy Neutral Loss of Heterozygosity by Gaymes, Terry J, Mohamedali, Azim, Eiliazadeh, Anthony L, Darling, David, Mufti, Ghulam J

“…Acquired copy neutral LOH (CN-LOH) is a frequent occurrence in myeloid malignancies and is often associated with resistance to standard therapeutic modalities…”
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Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value by Smith, Alexander E., Mohamedali, Azim M., Kulasekararaj, Austin, Lim, ZiYi, Gäken, Joop, Lea, Nicholas C., Przychodzen, Bartlomiej, Mian, Syed A., Nasser, Erick E., Shooter, Claire, Westwood, Nigel B., Strupp, Corinna, Gattermann, Norbert, Maciejewski, Jaroslaw P., Germing, Ulrich, Mufti, Ghulam J.

“…Mutations in the TET2 gene are frequent in myeloid disease, although their biologic and prognostic significance remains unclear. We analyzed 355 patients with…”
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Topography, Clinical, and Genomic Correlates of 5q Myeloid Malignancies Revisited by JEREZ, Andres, GONDEK, Lukasz P, MCDEVITT, Michael A, MUFTI, Ghulam J, MACIEJEWSKI, Jaroslaw P, JANKOWSKA, Anna M, MAKISHIMA, Hideki, PRZYCHODZEN, Bartlomiej, TIU, Ramon V, O'KEEFE, Christine L, MOHAMEDALI, Azim M, BATISTA, Denise, SEKERES, Mikkael A

“…Interstitial deletions of chromosome 5q are common in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), pointing toward the pathogenic role of…”
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Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies by Tiu, Ramon V., Gondek, Lukasz P., O'Keefe, Christine L., Elson, Paul, Huh, Jungwon, Mohamedali, Azim, Kulasekararaj, Austin, Advani, Anjali S., Paquette, Ronald, List, Alan F., Sekeres, Mikkael A., McDevitt, Michael A., Mufti, Ghulam J., Maciejewski, Jaroslaw P.

“…Single nucleotide polymorphism arrays (SNP-As) have emerged as an important tool in the identification of chromosomal defects undetected by metaphase…”
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Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis by Jerez, Andres, Sugimoto, Yuka, Makishima, Hideki, Verma, Amit, Jankowska, Anna M., Przychodzen, Bartlomiej, Visconte, Valeria, Tiu, Ramon V., O'Keefe, Christine L., Mohamedali, Azim M., Kulasekararaj, Austin G., Pellagatti, Andrea, McGraw, Kathy, Muramatsu, Hideki, Moliterno, Alison R., Sekeres, Mikkael A., McDevitt, Michael A., Kojima, Seiji, List, Alan, Boultwood, Jacqueline, Mufti, Ghulam J., Maciejewski, Jaroslaw P.

“…Loss of heterozygosity affecting chromosome 7q is common in acute myeloid leukemia and myelodysplastic syndromes, pointing toward the essential role of this…”
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Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome by Mian, Syed A, Smith, Alexander E, Kulasekararaj, Austin G, Kizilors, Aytug, Mohamedali, Azim M, Lea, Nicholas C, Mitsopoulos, Konstantinos, Ford, Kevin, Nasser, Erick, Seidl, Thomas, Mufti, Ghulam J

“…The recent identification of acquired mutations in key components of the spliceosome machinery strongly implicates abnormalities of mRNA splicing in the…”
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Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies by Gaymes, Terry J, Mohamedali, Azim M, Patterson, Miranda, Matto, Nazia, Smith, Alexander, Kulasekararaj, Austin, Chelliah, Rajani, Curtin, Nicola, Farzaneh, Farzin, Shall, Sydney, Mufti, Ghulam J

“…Inactivation of the DNA mismatch repair pathway manifests as microsatellite instability, an accumulation of mutations that drives carcinogenesis. Here, we…”
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The effects of 5-azacytidine on the function and number of regulatory T cells and T-effectors in myelodysplastic syndrome by Costantini, Benedetta, Kordasti, Shahram Y, Kulasekararaj, Austin G, Jiang, Jie, Seidl, Thomas, Abellan, Pilar Perez, Mohamedali, Azim, Thomas, Nicolas Shaun B, Farzaneh, Farzin, Mufti, Ghulam J

“…Expansion of regulatory T cells occurs in high-risk myelodysplastic syndrome and correlates with a poor prognosis. DNA methyltransferase inhibitors,…”
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Utility of peripheral blood for cytogenetic and mutation analysis in myelodysplastic syndrome by Mohamedali, Azim M., Alkhatabi, Heba, Kulasekararaj, Austin, Shinde, Sneha, Mian, Syed, Malik, Farooq, Smith, Alexander E., Gäken, Joop, Mufti, Ghulam J.

“…Recent studies have shown that more than 80% of bone marrow (BM) samples from patients with myelodysplastic syndrome (MDS) harbor somatic mutations and/or…”
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Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes by Mohamedali, Azim, Gäken, Joop, Twine, Natalie A., Ingram, Wendy, Westwood, Nigel, Lea, Nicholas C., Hayden, Janet, Donaldson, Nora, Aul, Carlo, Gattermann, Norbert, Giagounidis, Aristotle, Germing, Ulrich, List, Alan F., Mufti, Ghulam J.

“…Low-risk myelodysplastic syndrome (MDS) with normal cytogenetics accounts for approximately 50% of MDS patients. There are no pathognomonic markers in these…”
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Novel TET2 Mutations Associated With UPD4q24 in Myelodysplastic Syndrome by MOHAMEDALI, Azim M, SMITH, Alexander E, GAKEN, Joop, LEA, Nicholas C, MIAN, Syed A, WESTWOOD, Nigel B, STRUPP, Corinna, GATTERMANN, Norbert, GERMING, Ulrich, MUFTI, Ghulam J

“…Cryptic chromosomal aberrations, such as regions of uniparental disomy (UPD), have been shown to harbor homozygous mutations and are a common feature in…”
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Van‐den Berghe’s 5q‐ syndrome in 2008 by Mohamedali, Azim, Mufti, Ghulam J.

“…Summary Van Den Berghe established 5q‐ syndrome as a discrete clinical entity in 1974 when he described patients with macrocytic anaemia, thrombocytosis,…”
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A functional assay for microRNA target identification and validation by Gäken, Joop, Mohamedali, Azim M, Jiang, Jie, Malik, Farooq, Stangl, Doris, Smith, Alexander E, Chronis, Constantinos, Kulasekararaj, Austin G, Thomas, N Shaun B, Farzaneh, Farzin, Tavassoli, Mahvash, Mufti, Ghulam J

“…MicroRNAs (miRNA) are a class of small RNA molecules that regulate numerous critical cellular processes and bind to partially complementary sequences resulting…”
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Prevalence and clinical outcomes of the 46/1 haplotype, Janus kinase 2 mutations, and ten‐eleven translocation 2 mutations in budd‐chiari syndrome and their impact on thrombotic complications post Liver Transplantation by Westbrook, Rachel H., Lea, Nicholas C., Mohamedali, Azim M., Smith, Alexander E., Orr, David W., Roberts, Lara N., Heaton, Nigel D., Wendon, Julia A., O'Grady, John G., Heneghan, Michael A., Mufti, Ghulam J.

“…Latent myeloproliferative disorders (MPDs) can be identified by Janus kinase 2 (JAK2) mutations in patients with idiopathic Budd‐Chiari syndrome (BCS). The…”
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CSNK1A1 mutations and isolated del(5q) abnormality in myelodysplastic syndrome: a retrospective mutational analysis by Smith, Alexander E, PhD, Kulasekararaj, Austin G, FRCPath, Jiang, Jie, PhD, Mian, Syed, BSc, Mohamedali, Azim, PhD, Gaken, Joop, PhD, Ireland, Robin, FRCPath, Czepulkowski, Barbara, BSc, Best, Steven, PhD, Mufti, Ghulam J, Prof

“…Summary Background A mechanism for clonal growth advantage in isolated del(5q) disease remains elusive. CSNK1A1 resides on the critically deleted region, and…”
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Non-del(5q) myelodysplastic syndromes–associated loci detected by SNP-array genome-wide association meta-analysis by McGraw, Kathy L., Cheng, Chia-Ho, Chen, Y. Ann, Hou, Hsin-An, Nilsson, Björn, Genovese, Giulio, Cluzeau, Thomas, Pellagatti, Andrea, Przychodzen, Bartlomiej P., Mallo, Mar, Arenillas, Leonor, Mohamedali, Azim, Adès, Lionel, Sallman, David A., Padron, Eric, Sokol, Lubomir, Moreilhon, Chimene, Raynaud, Sophie, Tien, Hwei-Fang, Boultwood, Jacqueline, Ebert, Benjamin L., Sole, Francesc, Fenaux, Pierre, Mufti, Ghulam J., Maciejewski, Jaroslaw P., Kanetsky, Peter A., List, Alan F.

“…Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies. Known predisposing factors to adult MDS include rare germline mutations, cytotoxic…”
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Immunotherapy of myeloid leukaemia by Guinn, Barbara-Ann, Mohamedali, Azim, Thomas, N Shaun B, Mills, Ken I

“…The treatment of myeloid leukaemia has progressed in recent years with the advent of donor leukocyte infusions (DLI), haemopoietic stem cell transplants…”
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