Search Results - "Mohamed eChahine"

Biophysics, pathophysiology, and pharmacology of ion channel gating pores by Moreau, Adrien, Gosselin-Badaroudine, Pascal, Chahine, Mohamed

“…Voltage sensor domains (VSDs) are a feature of voltage gated ion channels (VGICs) and voltage sensitive proteins. They are composed of four transmembrane (TM)…”
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Recent advances in voltage-gated sodium channels, their pharmacology and related diseases by Mohamed eChahine, Jean-François eDesaphy

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Mutations in the Voltage Sensors of Domains I and II of Nav1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents by Moreau, Adrien, Gosselin-Badaroudine, Pascal, Boutjdir, Mohamed, Chahine, Mohamed

“…Voltage gated sodium channels (Nav) are transmembrane proteins responsible for action potential initiation. Mutations mainly located in the voltage sensor…”
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Correlation of the electrophysiological profiles and sodium channel transcripts of individual rat dorsal root ganglia neurons by Thériault, Olivier, Chahine, Mohamed

“…Voltage gated sodium channels (Nav channels) play an important role in nociceptive transmission. They are intimately tied to the genesis and transmission of…”
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Sudden death of cardiac origin and psychotropic drugs by Timour, Quadiri, Frassati, Dominique, Descotes, Jacques, Chevalier, Philippe, Christé, Georges, Chahine, Mohamed

“…Mortality rate is high in psychiatric patients versus general population. An important cause of this increased mortality is sudden cardiac death (SCD) as a…”
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New insights into cardiac and brain sodium channels modulation by Beta blockers by Chahine, Mohamed

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MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Nav1.5 sodium channels by O'Leary, Michael E, Chahine, Mohamed

“…The transmembrane S6 segments of Na(+) sodium channels form the cytoplasmic entrance of the channel and line the internal aspects of the aqueous pore. This…”
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Regulatory role of voltage-gated sodium channel β subunits in sensory neurons by Mohamed eChahine, Michael E O'Leary

“…Voltage-gated Na+ channels are transmembrane-bound proteins incorporating aqueous conduction pores that are highly selective for Na+. The opening of these…”
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Recent advances in voltage-gated sodium channels, their pharmacology, and related diseases by Desaphy, Jean-François, Chahine, Mohamed

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Mexiletine differentially restores the trafficking defects caused by two brugada syndrome mutations by Moreau, Adrien, Keller, Dagmar I, Huang, Hai, Fressart, Véronique, Schmied, Christian, Timour, Quadiri, Chahine, Mohamed

“…The human cardiac sodium channel Na(v)1.5 encoded by the SCN5A gene plays a critical role in cardiac excitability and the propagation of action potentials…”
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Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutation by Moreau, Adrien, Krahn, Andrew D, Gosselin-Badaroudine, Pascal, Klein, George J, Christé, Georges, Vincent, Yohann, Boutjdir, Mohamed, Chahine, Mohamed

“…Long QT syndrome (LQTS) is a congenital abnormality of cardiac repolarization that manifests as a prolonged QT interval on 12-lead electrocardiograms (ECGs)…”
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