Synthesis and cytotoxic activity of some novel benzocoumarin derivatives under solvent free conditions

Synthesis and cytotoxic activity of some novel benzocoumarin derivatives under solvent free conditions

In the present study, a rapid, less expensive, clean and environmental friendly route to synthesis new pyrazoles, pyrazolopyridazines and condensed pyrimidines was developed via grinding of 2-(3-(dimethylamino)acryloyl)-3H-benzo[f]chromen-3-one (1) with different reagents. All the new compounds were...

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Bibliographic Details
Published in:Green chemistry letters and reviews Vol. 12; no. 1; pp. 9 - 18
Main Authors: Abdel-Aziem, Anhar, Rashdan, Huda Refaat Mahmoud, Mohamed Ahmed, Entesar, Shabaan, Sara N.
Format: Journal Article
Language:English
Published: Abingdon Taylor & Francis 02-01-2019
Taylor & Francis Ltd
Taylor & Francis Group
Subjects:
Breast
Colon
coumarins
Cytotoxicity
Green chemistry
hydrazonoyl halides
Leukemia
Melanoma
Prostate
Pyrazoles
pyrazolo[3,4-d]pyridazines
Pyrimidines
Reagents
sulphadrugs
Synthesis
Tumor cell lines
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Summary:In the present study, a rapid, less expensive, clean and environmental friendly route to synthesis new pyrazoles, pyrazolopyridazines and condensed pyrimidines was developed via grinding of 2-(3-(dimethylamino)acryloyl)-3H-benzo[f]chromen-3-one (1) with different reagents. All the new compounds were characterized and established using elemental analysis and spectral data. Eight compounds were selected for in vitro antiproliferative against different human cancer cell lines entitled melanoma, cancers of the lung, leukemia, breast, brain, colon, prostate, ovary and kidney by the USA NCI.
ISSN:1751-8253
1751-7192
DOI:10.1080/17518253.2018.1556743