Search Results - "Mohamed A. Alfaleh"

Phage Display Derived Monoclonal Antibodies: From Bench to Bedside by Alfaleh, Mohamed A, Alsaab, Hashem O, Mahmoud, Ahmad Bakur, Alkayyal, Almohanad A, Jones, Martina L, Mahler, Stephen M, Hashem, Anwar M

“…Monoclonal antibodies (mAbs) have become one of the most important classes of biopharmaceutical products, and they continue to dominate the universe of…”
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Evaluation of Neutralizing Antibodies Against Highly Pathogenic Coronaviruses: A Detailed Protocol for a Rapid Evaluation of Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudovirus-Based Assay by Almahboub, Sarah A, Algaissi, Abdullah, Alfaleh, Mohamed A, ElAssouli, M-Zaki, Hashem, Anwar M

“…Emerging highly pathogenic human coronaviruses (CoVs) represent a serious ongoing threat to the public health worldwide. The spike (S) proteins of CoVs are…”
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Formulation Design, Statistical Optimization, and In Vitro Evaluation of a Naringenin Nanoemulsion to Enhance Apoptotic Activity in A549 Lung Cancer Cells by Md, Shadab, Alhakamy, Nabil A., Aldawsari, Hibah M., Husain, Mohammad, Kotta, Sabna, Abdullah, Samaa T., A. Fahmy, Usama, Alfaleh, Mohamed A., Asfour, Hani Z.

“…Naringenin (NAR), a flavonoid mainly found in citrus and grapefruits, has proven anti-cancer activities. However, the poor water solubility and low…”
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SARS-CoV-2 S1 and N-based serological assays reveal rapid seroconversion and induction of specific antibody response in COVID-19 patients by Algaissi, Abdullah, Alfaleh, Mohamed A., Hala, Sharif, Abujamel, Turki S., Alamri, Sawsan S., Almahboub, Sarah A., Alluhaybi, Khalid A., Hobani, Haya I., Alsulaiman, Reem M., AlHarbi, Rahaf H., ElAssouli, M.-Z.aki, Alhabbab, Rowa Y., AlSaieedi, Ahdab A., Abdulaal, Wesam H., Al-Somali, Afrah A., Alofi, Fadwa S., Khogeer, Asim A., Alkayyal, Almohanad A., Mahmoud, Ahmad Bakur, Almontashiri, Naif A. M., Pain, Arnab, Hashem, Anwar M.

“…As the Coronavirus Disease 2019 (COVID-19), which is caused by the novel SARS-CoV-2, continues to spread rapidly around the world, there is a need for well…”
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Wasp venom peptide improves the proapoptotic activity of alendronate sodium in A549 lung cancer cells by Alhakamy, Nabil A, Okbazghi, Solomon Z, A Alfaleh, Mohamed, H Abdulaal, Wesam, Bakhaidar, Rana B, Alselami, Mohammed O, Zahrani, Majed Al, Alqarni, Hani M, F Alghaith, Adel, Alshehri, Sultan, Badr-Eldin, Shaimaa M, Aldawsari, Hibah M, Al-Hejaili, Omar D, Aldhabi, Bander M, Mahdi, Wael A

“…Lung cancer in men and women is considered the leading cause for cancer-related mortality worldwide. Anti-cancer peptides represent a potential untapped…”
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David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors by Alfaleh, Mohamed A., Zawawi, Ayat, Al-Amri, Sawsan S., Hashem, Anwar M.

“…Anti-SARS-CoV-2 monoclonal antibodies and vaccines have shown improvement in lowering viral burden and hospitalization. However, emerging SARS-CoV-2 variants…”
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Plumbagin-Loaded Glycerosome Gel as Topical Delivery System for Skin Cancer Therapy by Md, Shadab, Alhakamy, Nabil A, Aldawsari, Hibah M, Husain, Mohammad, Khan, Nazia, Alfaleh, Mohamed A, Asfour, Hani Z, Riadi, Yassine, Bilgrami, Anwar L, Akhter, Md Habban

“…Plumbagin (PLM) is a phytochemical which has shown cytotoxicity against of cancer cells both in vitro and in vivo. However, the clinical application of PLM has…”
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Targeting membrane proteins for antibody discovery using phage display by Jones, Martina L., Alfaleh, Mohamed A., Kumble, Sumukh, Zhang, Shuo, Osborne, Geoffrey W., Yeh, Michael, Arora, Neetika, Hou, Jeff Jia Cheng, Howard, Christopher B., Chin, David Y., Mahler, Stephen M.

“…A critical factor in the successful isolation of new antibodies by phage display is the presentation of a correctly folded antigen. While this is relatively…”
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Mouth rinses efficacy on salivary SARS‐CoV‐2 viral load: A randomized clinical trial by Alzahrani, Manar M., Bamashmous, Shatha, Alkharobi, Hanaa, Alghamdi, Abdullah, Alharbi, Rahaf H., Hassan, Ahmed M., Darwish, Manar, Bukhari, Abdullah, Mahmoud, Ahmad Bakur, Alfaleh, Mohamed A., Mirza, Ahmed A., Abuzenadah, Adel M., Abujamel, Turki S., Hashem, Anwar M.

“…Considering the global trend to confine the COVID‐19 pandemic by applying various preventive health measures, preprocedural mouth rinsing has been proposed to…”
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Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu by Akhter, Md Habban, Khalilullah, Habibullah, Gupta, Manish, Alfaleh, Mohamed A, Alhakamy, Nabil A, Riadi, Yassine, Md, Shadab

“…Nanoparticles (NPs) in contact with a biological medium are rapidly comprehended by a number of protein molecules resulting in the formation of an NP-protein…”
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Retraction Note: Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer by Alfaleh, Mohamed A., Fahmy, Omar, Al-Rabia, Mohammed W., Abourehab, Mohammed A. S., Ahmed, Osama A. A., Fahmy, Usama A., Alsulimani, Helal H., Badr-Eldin, Shaimaa M., Aldawsari, Hibah M., Aldhabi, Bander M., Alharbi, Awaad S., Alhakamy, Nabil A.

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Apigenin Loaded Lipoid-PLGA-TPGS Nanoparticles for Colon Cancer Therapy: Characterization, Sustained Release, Cytotoxicity, and Apoptosis Pathways by Alfaleh, Mohamed A, Hashem, Anwar M, Abujamel, Turki S, Alhakamy, Nabil A, Kalam, Mohd Abul, Riadi, Yassine, Md, Shadab

“…Colon cancer (CC) is one of major causes of mortality and affects the socio-economic status world-wide. Therefore, developing a novel and efficient delivery…”
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Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells by Alhakamy, Nabil A, Badr-Eldin, Shaimaa M, A Fahmy, Usama, Alruwaili, Nabil K, Awan, Zuhier A, Caruso, Giuseppe, Alfaleh, Mohamed A, Alaofi, Ahmed L, Arif, Faris O, Ahmed, Osama A A, Alghaith, Adel F

“…Thymoquinone (TQ), a natural polyphenol, has been associated with various pharmacological responses; however, low bioavailability of TQ limits its clinical…”
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Pathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations by Iqubal, Ashif, Iqubal, Mohammad Kashif, Sharma, Sumit, Wasim, Mohd, Alfaleh, Mohamed A., Md, Shadab, Baboota, Sanjula, Ali, Javed, Haque, Syed Ehtaishamul

“…Radiotherapy is one of the extensively used therapeutic modalities in glioblastoma and other types of cancers. Radiotherapy is either used as a first-line…”
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Scorpion Venom-Functionalized Quercetin Phytosomes for Breast Cancer Management: In Vitro Response Surface Optimization and Anticancer Activity against MCF-7 Cells by Alhakamy, Nabil A, Fahmy, Usama A, Eldin, Shaimaa M Badr, Ahmed, Osama A A, Aldawsari, Hibah M, Okbazghi, Solomon Z, Alfaleh, Mohamed A, Abdulaal, Wesam H, Alamoudi, Abdulmohsin J, Mady, Fatma M

“…Breast cancer is a dangerous type of cancer in women. Quercetin (QRT), a naturally occurring flavonoid, has wide biological effects including antioxidant,…”
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Drug reprofiling history and potential therapies against Parkinson's disease by Latif, Komal, Ullah, Aman, Shkodina, Anastasiia D, Boiko, Dmytro I, Rafique, Zakia, Alghamdi, Badrah S, Alfaleh, Mohamed A, Ashraf, Ghulam Md

“…Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing "old" drugs to treat typical and…”
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RETRACTED ARTICLE: Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer by Alfaleh, Mohamed A., Fahmy, Omar, Al-Rabia, Mohammed W., Abourehab, Mohammed A. S., Ahmed, Osama A. A., Fahmy, Usama A., H. Alsulimani, Helal, Badr-Eldin, Shaimaa M., Aldawsari, Hibah M., Aldhabi, Bander M., Alharbi, Awaad S., Alhakamy, Nabil A.

“…As a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, Fluvastatin (FLV) is used for reducing low-density lipoprotein (LDL) cholesterol as well…”
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The importance of combining serological testing with RT-PCR assays for efficient detection of COVID-19 and higher diagnostic accuracy by Alamri, Sawsan S, Alsaieedi, Ahdab, Khouqeer, Yousef, Afeef, Marwah, Alharbi, Samiyah, Algaissi, Abdullah, Alghanmi, Maimonah, Altorki, Tarfa, Zawawi, Ayat, Alfaleh, Mohamed A, Hashem, Anwar M, Alhabbab, Rowa

“…Misdiagnosing suspected COVID-19 individuals could largely contribute to the viruses transmission, therefore, making an accurate diagnosis of infected subjects…”
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Recent Developments in Diagnosis of Epilepsy: Scope of MicroRNA and Technological Advancements by Bandopadhyay, Ritam, Singh, Tanveer, Ghoneim, Mohammed M, Alshehri, Sultan, Angelopoulou, Efthalia, Paudel, Yam Nath, Piperi, Christina, Ahmad, Javed, Alhakamy, Nabil A, Alfaleh, Mohamed A, Mishra, Awanish

“…Epilepsy is one of the most common neurological disorders, characterized by recurrent seizures, resulting from abnormally synchronized episodic neuronal…”
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Optimized 2-methoxyestradiol invasomes fortified with apamin: a promising approach for suppression of A549 lung cancer cells by Awan, Zuhier A., AlGhamdi, Shareefa A., Alhakamy, Nabil A., Okbazghi, Solomon Z., Alfaleh, Mohamed A., Badr-Eldin, Shaimaa M., Aldawsari, Hibah M., Abourehab, Mohammed A. S., Asfour, Hani Z., Zakai, Shadi A., Alrabia, Mohammad W., Negm, Aya A., El-Moselhy, Mohamed A., Sharkawi, Sara S., Rizg, Waleed Y.

“…Certain anticancer agents selectively target the nucleus of cancer cells. One such drug is 2-methoxyestradiol (2ME), which is used for treating lung cancer. To…”
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