Search Results - "Mohamed, Naeemunnisa"
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Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model
Published in International journal of nanomedicine (01-01-2020)“…Despite tremendous results achieved by immune checkpoint inhibitors, most patients are not responders, mainly because of the lack of a pre-existing anti-tumor…”
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NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models
Published in International journal of nanomedicine (01-01-2021)“…The side effects of radiotherapy induced on healthy tissue limit its use. To overcome this issue and fully exploit the potential of radiotherapy to treat…”
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DNA damage enhancement by radiotherapy-activated hafnium oxide nanoparticles improves cGAS-STING pathway activation in human colorectal cancer cells
Published in Radiotherapy and oncology (01-12-2019)“…The cGAS-STING pathway can be activated by radiation induced DNA damage and because of its important role in anti-cancer immunity activation, methods to…”
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Radiotherapy-activated NBTXR3 nanoparticles modulate cancer cell immunogenicity and TCR repertoire
Published in Cancer cell international (03-06-2022)“…Radiotherapy is a powerful and widely used technique for the treatment of solid tumors. Beyond its ability to destroy tumor cells, it has been demonstrated…”
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Hafnium oxide nanoparticles: toward an in vitro predictive biological effect?
Published in Radiation oncology (London, England) (30-06-2014)“…Hafnium oxide, NBTXR3 nanoparticles were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. The purpose of this…”
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Abstract 4571: Activation of the cGAS-STING pathway by NBTXR3 nanoparticles exposed to radiotherapy
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Radiation therapy (RT) is one of the most used local treatment for many cancer types. In addition to DNA breaks and free radicals production leading…”
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Abstract LB-A30: Hafnium oxide nanoparticles with radiotherapy induce immunogenic cell death
Published in Molecular cancer therapeutics (01-01-2018)“…Abstract Background - Between 70 to 90% of patient have "cold" tumors, i.e. devoid or poorly infiltrated by immune cells, rendering inoperative their treatment…”
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Hafnium oxide nanoparticles: toward an in vitropredictive biological effect?
Published in Radiation oncology (London, England) (30-06-2014)“…Background Hafnium oxide, NBTXR3 nanoparticles were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. The…”
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